DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gl and stxbp5b

DIOPT Version :9

Sequence 1:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	XP_009291096.1	Gene:	stxbp5b / 571925	ZFINID:	ZDB-GENE-090821-5	Length:	1186	Species:	Danio rerio

Alignment Length:	1179	Identity:	287/1179 - (24%)
Similarity:	461/1179 - (39%)	Gaps:	373/1179 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASEL 83
            ||.:.|...||.:||||::||::|:|||.|::|||||:|||::||:.|||.|.||.  :.||
Zfish    53 LQSEHFQLCKTVRHGFPYQPSSMAFDPVQKILAIGTQSGALRLFGRAGVECYCQHE--SGSA--- 112

  Fly    84 NVQLLEWVYGTGRILSLTAANQLILW---EPVGATLLPIK---------TLPFDGKLKKVSSLCC 136
             |..||::...|.::|..|.:.:.||   :.:.|.|..:|         .|||..|
Zfish   113 -VIQLEFLVNVGALVSALADDSIHLWNLRQKLPAVLHSLKFNRERITFCHLPFQSK--------- 167

  Fly   137 SLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLPNSPSKLL 201
                 .|::|||.|||:.:::.:||:...||..:..:|.   :.|.:||.:..|...|....|||
Zfish   168 -----WLYVGTERGNIHIVNVESFTLSGYVIMWNKAIEL---SSKTHPGPVVHISDNPMDEGKLL 224

  Fly   202 VAYNRGLCVLWDFESASVQRAYIAPGHGQSV-GLTVNFEGSEFTWYHADGSYATWSIDNPEPPSN 265
            :.:..|:.||||.:|......|   .:.::: .:..:.||.:|...|:||:..||::..|..|:.
Zfish   225 IGFECGIVVLWDLKSKKADYRY---NYDEAIHSVAWHHEGKQFVCSHSDGTLTTWNVRAPAKPAQ 286

  Fly   266 VNYVPYG--------PDPCKSINRL-YKGKRRSNDVIVFSGGMPRSAYGDHNCVSV-HASDGHKV 320
            : ..|:|        |:|||.|.:: ||..|..:..::..||:.....|...|::| |......:
Zfish   287 I-ITPHGKQPKDGKKPEPCKPILKVEYKTTRAGDPFMILCGGLSYDTVGRRACLTVMHGKSTAVL 350

  Fly   321 CLDFTSKVIDFFVTFE----NNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPYLHSVHASAVT- 380
            .:|:  .::||....|    |:......:|||||::|...||........:.||..|:|.|.||
Zfish   351 EMDY--PIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVVIDLAQIGYPIFENPYPLSIHESPVTC 413

  Fly   381 CNYLA---SEVVQSVYESILRAGDEQDID-YSNISWPITGGTLPDNLEESVEEDATKLYEILLTG 441
            |.|.|   :|.:.::|.    .|..|... :|...|||:.|        :..:......||::||
Zfish   414 CEYFADCPAEAIPALYS----VGSRQKRQGFSKKEWPISAG--------NWGQGTLSFSEIIITG 466

  Fly   442 HEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKSGLFDPYSD 506
            |.|||:||||.:.::|:.:|..||:.:|.......:.::.|:    |||           ||:
Zfish   467 HADGSIKFWDASALMLQVLYKLKTAKVFDKPRSKEEKSSTDI----VDE-----------DPF-- 514

  Fly   507 DPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFID---LPEKVSLKYISM----NLVSDRDGFVWK 564
                |::.:::||::..|.|.|.:..:::..|..   ..|.|.|..:.|    |.|...:|
Zfish   515 ----AIQMLSWCPESRVLCVAGVSAHVIVYRFSKQEVTTEVVQLLEVRMQCELNEVESPEG---- 571

  Fly   565 GHDQLNVRS----------------------NLLDG--EAIPTTE---------RGVNISGVLQV 596
            |.||.:..|                      |..||  :.:|..:         .|.::..::|:
Zfish   572 GGDQASAVSTPGTAPSPQTSLPQSHPSTSSNNSCDGLRDNVPCLKVRSSPLKQFPGYHVELLIQL 636

  Fly   597 L-----PPASITCMALEASWGLVSGGTAHGLVLFDF--KNFV------------PVFHRCTLNPN 642
            :     ||..||.:|:.:::|||:.|..:||.:.|:  |..:            ...||...:|.
Zfish   637 VWVSGEPPQQITSLAINSAYGLVAFGNGNGLAVVDYIQKTLLLNVTTAELYGSTDPHHRQPRSPR 701

  Fly   643 DLTGAGEQLSRRKSFKKSL----RESFRKLRKG---------RSTRTNQSNQVPTTLEARP---- 690
            ...........:||....|    .||.:|||..         .|....:..:.||:....|
Zfish   702 KTRQPSADTLHKKSCMSGLSNFYSESVKKLRSSYLSLCDGNDASAAPEERCKSPTSGSGSPCNSD 766

  Fly   691 -------VER------QIEARCADDGLGSMVRCLLFAK-------------------------TY 717
                   :||      :|....|:|          |||                         :.
Zfish   767 EDSKQKFIERVKTKSKRISKTVAND----------FAKISRKINMLADQKDDARDNSFSRSRSSS 821

  Fly   718 VTNVN----------------------ITSPTLWSATNASTVSVFLLHLP--PAQTAATAVP--- 755
            ||:::                      :..|:||..|:..::....|.:|  |.|.....|.
Zfish   822 VTSIDRESREVISSFYFCDSLSKKSETLAVPSLWVGTSLGSMLAIALTVPSTPEQRMQQPVGVSF 886

  Fly   756 -----------------SASGNAPPHM----------------PRRISAQLAKEIQLKHRAPVVG 787
                             .|||...||:                |||             |.|.
Zfish   887 CGSVVRLKGAILRMAQLDASGTVLPHIYEPWYEPNAPEEERERPRR-------------RRPT-- 936

  Fly   788 ISIFDQAGSPVDQLNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGS 852
                    ||.   ::.||....:.| :.||:|.||.:||....|.::.:|.           .|
Zfish   937 --------SPP---SSQENQDCQYAV-VCSEKQAKVVALPSQHCIFEHNITE-----------AS 978

  Fly   853 FSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNET---ALICLTNMGDIMV 914
            |                                      |.|.||...|   |:.|....|.||.
Zfish   979 F--------------------------------------VLRADVVTMTAGVAIACFCANGHIMT 1005

  Fly   915 LSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVEPL 979
            ||:|.|:..|:...:...|:....:.||:|.|:|||:.|.:|:|||..:.            |..
Zfish  1006 LSLPSLRPLLDVNYLPLTDMRIARTFCFSNQGQALYLTSPTEIQRITYSQ------------ETC 1058

  Fly   980 ENEESVLEE 988
            ||.:.:|.|
Zfish  1059 ENLQEMLGE 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	22/38 (58%)
		WD40 repeat	84..126	CDD:293791	14/53 (26%)
		WD40 repeat	131..174	CDD:293791	11/42 (26%)
		WD40 repeat	188..224	CDD:293791	11/35 (31%)
		LLGL	268..>338	CDD:285555	20/83 (24%)
stxbp5b	XP_009291096.1	WD40	<58..279	CDD:225201	82/246 (33%)
		WD40	73..>280	CDD:295369	74/232 (32%)
		WD40 repeat	73..106	CDD:293791	20/32 (63%)
		WD40 repeat	114..152	CDD:293791	9/37 (24%)
		WD40 repeat	157..203	CDD:293791	16/62 (26%)
		WD40 repeat	211..247	CDD:293791	12/38 (32%)
		WD40 repeat	252..284	CDD:293791	9/31 (29%)
		LLGL	288..395	CDD:285555	29/108 (27%)
		R-SNARE_STXBP5	1119..1179	CDD:277246
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11455
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122541at2759
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820