DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gl and stxbp5l

DIOPT Version :9

Sequence 1:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	XP_005167782.1	Gene:	stxbp5l / 567605	ZFINID:	ZDB-GENE-041210-220	Length:	1267	Species:	Danio rerio

Alignment Length:	1315	Identity:	318/1315 - (24%)
Similarity:	507/1315 - (38%)	Gaps:	364/1315 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASEL 83
            |..:.|...||.:||||::|:|||:|||.|::|||:::|.:::.|:|||:.:.||   .:.|:.|
Zfish    47 LMSEHFQICKTVRHGFPYQPTALAFDPVQKILAIGSRSGGIRILGRPGVDCHSQH---ESGAAVL 108

  Fly    84 NVQLLEWVYGTGRILSLTAANQLILW---EPVGATLLPIK---------TLPFDGKLKKVSSLCC 136
            .:|.|   ...|.:::..|.:.|.||   :.:.|.|..:|         .|||..|
Zfish   109 QMQFL---INEGALVTACADDTLHLWSLRQRLPAILHSLKFNRERITFCHLPFQSK--------- 161

  Fly   137 SLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLPNSPSKLL 201
                 .|::|||.||.:.:::.:|.:...||..:..:|.   :.|.:||.:..:...|....|||
Zfish   162 -----WLYVGTERGNTHIVNIESFILSGYVIMWNKAIEL---STKTHPGPVVHLSDSPKDEGKLL 218

  Fly   202 VAYNRGLCVLWDFESASVQRAYIAPGHGQSV-GLTVNFEGSEFTWYHADGSYATWSIDNPEPPSN 265
            :.:..|..|:||..:   :||.....:.::: .::.:.||.:|...|:|||.:.|::.|...|..
Zfish   219 IGFESGTIVMWDLRA---KRADFRIYYDEAIHSVSWHHEGRQFMCSHSDGSLSMWNMRNTAKPFQ 280

  Fly   266 VNYVPYG-------PDPCKSINRL-YKGKRRSNDV-IVFSGGMPRSAYGDHNCVSVHASDGHKVC 321
            |.: |:|       .:.||.|.:: ||..|.|::. ::||||:.....|....:::.......|
Zfish   281 VTF-PHGKTQRDGRKESCKPILKVEYKTSRNSSEAFVIFSGGLSYDKAGRRPTLTIMHGKAITV- 343

  Fly   322 LDFTSKVIDFFVTFENN--RDVAE--VLVVLLEEELCAYDLTDPNICAIKAPYLHSVHASAVTCN 382
            |:....::||.|..|..  .:|.|  .:|||||::....|||..|....:.||...||.|.|||.
Zfish   344 LEMDYPIVDFMVLCETPYLNEVQEPYAVVVLLEKDFVVVDLTQSNFPIFENPYPMDVHESPVTCT 408

  Fly   383 -YLAS---EVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEEDATKLY-EILLTGH 442
             |.|.   :::..:| ||  ....:...||:..||::|||.         ...::.| ||::|||
Zfish   409 AYFADCPPDIIPVLY-SI--GAKHKKTGYSHKEWPVSGGTW---------TVGSQTYPEIIITGH 461

  Fly   443 EDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADM--SAEQVDEGEPPFRKSGLFDPYS 505
            .|||:||||.|.:.|:.:|..|||.:      |......||  ||:.|:|           |||
Zfish   462 ADGSIKFWDATAITLQMLYKLKTSKV------FEKPKTGDMGRSADLVEE-----------DPY- 508

  Fly   506 DDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISMNLVSDRDGFVW------- 563
                 ||:.|::||::....|.|.:..:::..|........:..:.:.|..:.:..:.
Zfish   509 -----AVQMISWCPQSRIFCVVGISAHVILYRFSKHDANTIITSLELRLQCEMEDVISPSDTENT 568

  Fly   564 ------KGHDQL----NVRSNLLDG--EAIPTTE---------RGVNISGVLQVL-----PPASI 602
                  .||...    :.|||..|.  ::||..:         .|.....|:|:|     ||..|
Zfish   569 PCFSDPSGHSPQPQPPSPRSNTPDSVRDSIPCLKVKDRMIRMPPGYQAELVVQLLWVDGEPPQQI 633

  Fly   603 TCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSR-----RKS------ 656
            ||:.|.:::||::.|..:||.:.|:.....:....||   :|.|:.:...|     ||:
Zfish   634 TCLDLNSAYGLLALGNCNGLAVVDYLQKTILLCMSTL---ELYGSADPFQRLTRSPRKNRQSTSD 695

  Fly   657 ------------FKKSLRESFRKLRKGRSTRTNQSNQVPTTLE--ARPVERQIEARCADDGLG-- 705
                        .||.:|.|::.|.:      ...|||...||  ..|..........:|..|
Zfish   696 FCMRGLSNFYSDSKKRIRTSYQSLTE------LSDNQVSLDLERSKSPTSAPYTPSLHNDPRGTG 754

  Fly   706 ---SMVRCLLFAKTYVTNVNITSP--TLWSATNASTVSVFLLHLPPAQTAATAVPSASGNA---- 761
               |.:|...::..:....|:..|  .|...|:..|   .|.|:....|:.|:.|..||.|
Zfish   755 EPVSNLRSCHYSPVFYLLDNVKGPGRKLSLPTDLKT---DLDHVNGHCTSPTSQPCPSGRARVPG 816

  Fly   762 PPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGS--------PVDQLNAGENGSPPHRVLI--- 815
            .|..||           |..|.|  |...|.:|.|        ||..|.   .|.|..|.::
Zfish   817 GPEGPR-----------LARRGP--GRPPFRKAQSAACMEVSLPVSSLT---EGYPSRRAMLQQL 865

  Fly   816 ----------------------ASEEQFK------------------------------------ 822
                                  :.|..|.
Zfish   866 HGVSMYSHDEHHITNYSWSERESRENSFSRSRSSSVSSIDRETKEAVTTLQFAESYGRKSDSLPT 930

  Fly   823 -----------VFSLPQLKPINKYKLTAN-------------EGARIRRIHFGSFSCR----ISP 859
                       |..:|...|.::.:...:             :|:.:|   ||...|.    .||
Zfish   931 PCLWVGTSLGLVLIIPMSIPTDEQERQEDPVTVAPTGTVLMLKGSVLR---FGFLDCGGALINSP 992

  Fly   860 -ETLQSMH--------------GCSPTKSTRSHGDGEAD---------------------PNISG 888
             |..:..|              ..||:.|..:.|||...                     .||:.
Zfish   993 YEVWRDQHAPDDPDRPRKRKLVNFSPSSSQEACGDGHLAVVCSERQAKVFYMPSQACLYVHNITE 1057

  Fly   889 SLAVSRGDVY---NETALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALY 950
            |..|.|.||.   |...|.|....|.||:||:|.|:..|:.:.:...|:....:.||||.|:|||
Zfish  1058 SSFVLRADVVSVSNSVCLACFCANGHIMILSLPSLRPLLDVSYLPLTDMRIARTFCFTNGGQALY 1122

  Fly   951 MMSSSELQRIALATSRVV--QPTGVVPVEPLENEESVLEENDAENNKETYACDEVVNTYEIKNPS 1013
            :.|.:|:|||..:....|  |.|......|:|..|:                   .|...:|...
Zfish  1123 LCSPTEIQRITYSQEMCVNLQETLGELFTPIETPEA-------------------QNRGFLKGFF 1168

  Fly  1014 GISICTRPAEENVGRNSVQQVNGVNISNSPNQAN-ETISSSIGDITVDSVRDHLNMTTTTLCSIN 1077
            |.:..|...||..|..|..:.:.....:.|.|.. |.:.::.|.:..|..|          ..|.
Zfish  1169 GGNAQTFDREELFGEASAGKASRSLAQHIPGQGGIEGMKAAAGGVVGDLAR----------ARIA 1223

  Fly  1078 TEETIGRLSVLSTQT 1092
            .:|...||..|..:|
Zfish  1224 LDERGQRLGELEERT 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	17/38 (45%)
		WD40 repeat	84..126	CDD:293791	13/53 (25%)
		WD40 repeat	131..174	CDD:293791	9/42 (21%)
		WD40 repeat	188..224	CDD:293791	10/35 (29%)
		LLGL	268..>338	CDD:285555	20/78 (26%)
stxbp5l	XP_005167782.1	WD40	67..471	CDD:225201	130/443 (29%)
		WD40	67..>273	CDD:295369	64/231 (28%)
		WD40 repeat	67..103	CDD:293791	17/38 (45%)
		WD40 repeat	108..146	CDD:293791	10/40 (25%)
		WD40 repeat	151..199	CDD:293791	14/64 (22%)
		WD40 repeat	207..241	CDD:293791	10/36 (28%)
		WD40 repeat	246..284	CDD:293791	11/38 (29%)
		LLGL	282..389	CDD:285555	30/108 (28%)
		R-SNARE_STXBP5	1201..1260	CDD:277246	10/48 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810