DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gl and SPAC1F3.03

DIOPT Version :9

Sequence 1:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_593006.1	Gene:	SPAC1F3.03 / 2542372	PomBaseID:	SPAC1F3.03	Length:	1004	Species:	Schizosaccharomyces pombe

Alignment Length:	1215	Identity:	229/1215 - (18%)
Similarity:	379/1215 - (31%)	Gaps:	431/1215 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASELNVQL----LEWVYG 93
            ||...|.....|....|:||.:.|..:.::|:..|    |..::.:.::.:::.|    |..:..
pombe    39 GFSLNPVLWCLDHQQGLLAIVSSTNRIYIYGKQHV----QSVIVPDCSTIVHIALCAAYLIVIDS 99

  Fly    94 TGRILSLTAANQLILWEPVGATLLPIKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLH 158
            ...:||........|.:|.....|.          :||:......:.|.::.|...|::...|:.
pombe   100 RNTVLSYPLMKHRDLSKPAATYFLK----------QKVTCTVTDPTIDWVFFGMSDGSVVPWDVT 154

  Fly   159 TFTI---KEPVIY---HD----VVLEQVPPAYKLNPGAIESIRQLPNSPSKLLVAYNRGLCVLWD 213
            ...:   |.|.:|   |:    :.....|...||:|  :.|::..|.....:|:||..|: ||:.
pombe   155 RHCLGKFKVPNLYVPRHEEWRMMGYSYAPVPGKLSP--VVSVQIHPKDLGVILIAYPDGV-VLYS 216

  Fly   214 FESASVQRAY---IAPGHGQSVGLTVNFE------------GSEFTWYHADGSYATWSIDNPEP- 262
            ..:..|.|.|   .|||...:|....|:.            |..|..|:.|.::|.|.:|...|
pombe   217 IRTDEVIRFYELEYAPGSTAAVLSPHNYRRPIVKGIEWSPWGDHFVSYYTDSTFAFWDVDQEYPV 281

  Fly   263 ------PSNVN-YVPYGPDPCKSINRLYKGKR------RSNDVIVFSGGMPRSA-------YGDH 307
                  .||:: |.|...:|.|:.....:..|      .:...|:..||:|:.|       :...
pombe   282 QVRNFVDSNIHTYTPMQRNPPKTELEPIRSMRWCCCEDPTVSFILMLGGLPKEAPVKGISLFSYR 346

  Fly   308 NCVSVHASDGHKVCLDFTSKVIDFFVTFENNRD------------VAEVLVV------------- 347
            |..:              .|.::.|..|..|.:            |.::||:
pombe   347 NLPA--------------KKDVETFAEFFANPNSQRFFPFIDIPPVRDMLVIPSSSPHYNGSHNP 397

  Fly   348 ----LLEEE--LCAYDLTDPNICAIKAPYLHSVHASAVTCNYLASE--------VVQSVYESILR 398
                ||.|:  |...|::..||..:      |:......| :|||:        |.:.|:..|
pombe   398 KNLLLLSEDNSLSLLDISTGNISNM------SLSIPPSLC-FLASDFRVIAFQTVTKKVWNQI-- 453

  Fly   399 AGDEQDIDY-SNISWPITGGTLPDNLEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKP--I 460
               |..|.. |:.|....|...|..|::..|.:       ||......|:..||.:...:.|  .
pombe   454 ---EDTISVNSHYSCLFGGSPSPGYLKKLDERN-------LLITSTGLSLSIWDISQGFMNPSLC 508

  Fly   461 YNFKTSSIF------------GSESDFRDD-AAADMSAEQV-------DEGEPPFRKSGLFDPYS 505
            .|...||:.            .|.|.:..: :.||.....:       .|..|....:|::  ..
pombe   509 VNLDFSSVMRKHLTPSAFITTASFSTYNPEFSCADSFGRVIVCKRKNHKENLPAQLANGIY--RL 571

  Fly   506 DDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPE-KVSLKYISMNLVSDRDGFVWKGHDQL 569
            ||               .|::.||   :....:|||.. :|:|..:| |:     |||..|:.
pombe   572 DD---------------TLVLEGT---LHAQYYIDLKRGRVTLNQMS-NI-----GFVCIGYQ-- 610

  Fly   570 NVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVF 634
                   ||.......||.:|      |...||:.:.||
pombe   611 -------DGGITIIDMRGPHI------LCNTSISELGLE-------------------------- 636

  Fly   635 HRCTLNPNDLTGAGEQLSRRKSFKKSL---RESFRKLRKGRSTRTNQSNQVPTTLEARPVERQIE 696
            .|...:|:.||.|...:...|....|:   ..::|.:........:.|.:.....|:   .||::
pombe   637 RRGKPDPDFLTSAEFVVMNPKGSPSSIYVVTGTYRGMTLLFRIDPSSSGRFSAYFES---SRQLD 698

  Fly   697 AR-----CA--DDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVS--------VFLLHLPP 746
            .:     |:  .||                       .:.:||.:|..|        |||:::..
pombe   699 IKNIYKICSLTQDG-----------------------QIATATGSSLQSVGYPLPQEVFLVYIGD 740

  Fly   747 AQTAA-TAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQLNAGENGSPP 810
            :..:. ..:.:..||.....|....|.|......||...||.::
pombe   741 SGISVFNKINNQVGNLDWRKPVCCRAALVLSTVSKHMGSVVCVN--------------------- 784

  Fly   811 HRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRISPETLQSMHGCSPTKSTR 875
                  |:.....:|||.|:...|.:|..
pombe   785 ------SDLSVNWYSLPNLREERKMQLPL------------------------------------ 807

  Fly   876 SHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGVSSL 940
                 :.|.|     .:..||:...         ||.:   .|.|               |...|
pombe   808 -----DIDKN-----RLKEGDILGN---------GDYI---FPTL---------------GAHEL 835

  Fly   941 ---CFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVEP--------LENEESVLEEND---- 990
               |...||..|     :.|..:.|.|.....    ||..|        |..:.:..||.|
pombe   836 AFGCVLGSGRTL-----ANLAPMMLITHNASH----VPPRPSKSLWNWLLGEQSTSAEELDILLG 891

  Fly   991 AENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNISNSPNQANETISSSI- 1054
            .||..|:       ..:.::.|..||  .||||      ||:|    .::..|:..:::..|.|
pombe   892 GENRAES-------KVHTLETPKVIS--ARPAE------SVKQ----PLTPVPSMTSQSAQSYIP 937

  Fly  1055 --------GDITVDSVRDHLNMTTTTLCSINTEETIGRLSVLSTQ 1091
                    |...  .:.|||......|..|  |.|:..|..:|.:
pombe   938 PRRQQQQKGFFA--QINDHLAQRGNMLGGI--ENTMDDLEEMSAE 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	8/38 (21%)
		WD40 repeat	84..126	CDD:293791	7/45 (16%)
		WD40 repeat	131..174	CDD:293791	9/52 (17%)
		WD40 repeat	188..224	CDD:293791	11/38 (29%)
		LLGL	268..>338	CDD:285555	14/82 (17%)
SPAC1F3.03	NP_593006.1	WD40	45..283	CDD:295369	53/254 (21%)
		WD40 repeat	45..79	CDD:293791	8/37 (22%)
		WD40 repeat	85..122	CDD:293791	6/36 (17%)
		WD40 repeat	127..185	CDD:293791	10/57 (18%)
		WD40 repeat	192..229	CDD:293791	11/37 (30%)
		WD40 repeat	249..297	CDD:293791	11/47 (23%)
		WD40 repeat	309..359	CDD:293791	9/63 (14%)
		Lgl_C	524..899	CDD:285762	98/583 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10241
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000