DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gl and Llgl2

DIOPT Version :9

Sequence 1:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001239461.1	Gene:	Llgl2 / 217325	MGIID:	1918843	Length:	1051	Species:	Mus musculus

Alignment Length:	1083	Identity:	376/1083 - (34%)
Similarity:	561/1083 - (51%)	Gaps:	231/1083 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLKFIRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQP 65
            |.:|:| .|..|:  |.||::|||.:.||.:|||||:||||.|.|.|:::||||::||:|::|.|
Mouse     1 MRRFLR-TGHDPA--RERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAP 62

  Fly    66 GVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWE-------------------- 110
            |||..|.|.  .|:|    |..:.::.|..::::|...|.|.||.
Mouse    63 GVEFMGLHK--ENNA----VLQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEEESFTLRG 121

  Fly   111 PVGATLLPIKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTF-TIKEPVIYHDVVLE 174
            |.||.  |..|        :|:.:....|.:||::|||.||::.:.|..| |:.:..|..|.||:
Mouse   122 PPGAA--PSAT--------QVTEILPHSSGELLYLGTESGNVFVVQLPGFRTLHDRTICSDEVLQ 176

  Fly   175 QVPP------AYKLNPGAIESIRQLPNSPSKLLVAYNRGLCVLWD---------------FESAS 218
            .:|.      .:::    :|::::.|..|:::|:.|:|||.|:||               .|:||
Mouse   177 WLPEEARHRRVFEM----VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRALSHFLSSQQLENAS 237

  Fly   219 VQRAYIAPGHGQSVGLTVNFEGSEFTWYHADGSYATWSI----DNPEPPSNVNYVPYGPDPCKSI 279
            .||                 :|......|:|||:..|.:    .||||..  :.:||||.|||:|
Mouse   238 WQR-----------------DGCLIVTCHSDGSHCQWPVSSDTQNPEPLR--SSIPYGPFPCKAI 283

  Fly   280 NRLY-KGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTFENNR---- 339
            .::: ...|:.....:|.|||||::|||.:|:|| ..:|.:...||||:||||.|..|.:.
Mouse   284 TKIFWLTTRQGLPFTIFQGGMPRASYGDRHCISV-VHNGQQTAFDFTSRVIDFTVLSEADPAAAF 347

  Fly   340 DVAEVLVVLLEEELCAYDLTDPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQD 404
            |....||||.||||...||..|....::.|||.|:|.||:||::..|.:...::|.|:.||..|:
Mouse   348 DDPYALVVLAEEELVVIDLQTPGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQN 412

  Fly   405 IDYSNISWPITGGT--LPDNLEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSS 467
            ..:|.:.|||.|||  .|...:.          ::||||||||:|:|||.:||.|:.:|...|..
Mouse   413 SHFSTMEWPIDGGTSLAPPPPQR----------DLLLTGHEDGTVRFWDASGVCLRLLYKLSTVR 467

  Fly   468 IFGSESDFRDDAAADMSAEQVDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQ 532
            :|.:::    |.:.::.|:..||. ||.||.|.||||||||||.::||..|..:|.|.|.|||||
Mouse   468 VFLTDT----DPSENLIAQGEDEW-PPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQ 527

  Fly   533 IVIADFIDLPEKVSLKYISMNLVSDRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVL 597
            :::.:..|...:.:::.:..:|:.|::|:.||||::|..|...:..||      |.....::|..
Mouse   528 VLVLELNDEAAEHAVEQVEADLLQDQEGYRWKGHERLAARPGPVCFEA------GFQPFVLVQCQ 586

  Fly   598 PPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLR 662
            |||.:|.:||.:.|.||:.||:||..|||.:....||.:|||:|:|.......|||.||.|||||
Mouse   587 PPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLR 651

  Fly   663 ESFRKLRKGRSTRTNQSNQVPT------------------------------------------T 685
            :|||::|:.|.:...:....||                                          .
Mouse   652 QSFRRMRRSRVSSHKRRPGGPTGEVRPQAQSSHLQDHTALPQDLNPDQAQAQAVNIKAERTGLQN 716

  Fly   686 LEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVSVFLLHLPPAQTA 750
            :|..||:|:||||.|:|.....||.|.||.||:.:.:...|:||:.||..||..|.|.:|||:
Mouse   717 MELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFSLRVPPAE-- 779

  Fly   751 ATAVPSASGNAPPHMPRR----ISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQ-------LNAG 804
                            ||    :.|:.||||||.||||||||.:.|....|:.:       |:..
Mouse   780 ----------------RRTDEPVRAEQAKEIQLMHRAPVVGILVLDGHNVPLPEPLEVAHDLSKS 828

  Fly   805 ENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRI---HFGSFSCRISPETLQSMH 866
            .:....|::|:.||||||||:||::....|.||||.||:|:||:   ||||
Mouse   829 PDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVGVAHFGS-------------- 879

  Fly   867 GCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPELKRQLNAAAVRR 931
             |                         |.:.|.|..|..|||:|||.|:|:|.||.|:..:.:||
Mouse   880 -C-------------------------RAEDYGEHHLAVLTNLGDIQVVSMPLLKPQVRYSCIRR 918

  Fly   932 EDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVV 974
            ||::|::|..||..|:..|::|.||.:|.:|:|..:|:|..:|
Mouse   919 EDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLV 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	20/38 (53%)
		WD40 repeat	84..126	CDD:293791	12/61 (20%)
		WD40 repeat	131..174	CDD:293791	15/43 (35%)
		WD40 repeat	188..224	CDD:293791	16/50 (32%)
		LLGL	268..>338	CDD:285555	32/70 (46%)
Llgl2	NP_001239461.1	WD40 repeat	35..67	CDD:293791	19/31 (61%)
		WD40	<36..267	CDD:225201	74/267 (28%)
		WD40 repeat	76..120	CDD:293791	7/43 (16%)
		WD40 repeat	127..153	CDD:293791	10/33 (30%)
		WD40 repeat	192..228	CDD:293791	11/35 (31%)
		LLGL	271..371	CDD:369834	44/100 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848765
Domainoid	1	1.000	340	1.000	Domainoid score	I1089
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	672	1.000	Inparanoid score	I731
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		otm42628
orthoMCL	1	0.900	-	-		OOG6_104800
Panther	1	1.100	-	-	LDO	PTHR10241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770