Protein Alignment l(2)gl and Llgl2

DIOPT Version :10

• Sequence 1: NP_523439.2
• Gene: l(2)gl / 33156
• FlyBaseID: FBgn0002121
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_001239461.1
• Gene: Llgl2 / 217325
• MGIID: 1918843
• Length: 1051
• Species: Mus musculus
• Alignment Length: 1083
• Identity: 376/1083 - (34%)
• Similarity: 561/1083 - (51%)
• Gaps: 231/1083 - (21%)

  Fly     1 MLKFIRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQP 65
            |.:|:| .|..|:  |.||::|||.:.||.:|||||:||||.|.|.|:::||||::||:|::|.|
Mouse     1 MRRFLR-TGHDPA--RERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAVKLYGAP 62

  Fly    66 GVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWE-------------------- 110
            |||..|.|.  .|:|    |..:.::.|..::::|...|.|.||.
Mouse    63 GVEFMGLHK--ENNA----VLQIHFLPGQCQLVTLLDDNSLHLWSLKVKGGVSELQEEESFTLRG 121

  Fly   111 PVGATLLPIKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTF-TIKEPVIYHDVVLE 174
            |.||.  |..|        :|:.:....|.:||::|||.||::.:.|..| |:.:..|..|.||:
Mouse   122 PPGAA--PSAT--------QVTEILPHSSGELLYLGTESGNVFVVQLPGFRTLHDRTICSDEVLQ 176

  Fly   175 QVPP------AYKLNPGAIESIRQLPNSPSKLLVAYNRGLCVLWD---------------FESAS 218
            .:|.      .:::    :|::::.|..|:::|:.|:|||.|:||               .|:||
Mouse   177 WLPEEARHRRVFEM----VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRALSHFLSSQQLENAS 237

  Fly   219 VQRAYIAPGHGQSVGLTVNFEGSEFTWYHADGSYATWSI----DNPEPPSNVNYVPYGPDPCKSI 279
            .||                 :|......|:|||:..|.:    .||||..  :.:||||.|||:|
Mouse   238 WQR-----------------DGCLIVTCHSDGSHCQWPVSSDTQNPEPLR--SSIPYGPFPCKAI 283

  Fly   280 NRLY-KGKRRSNDVIVFSGGMPRSAYGDHNCVSVHASDGHKVCLDFTSKVIDFFVTFENNR---- 339
            .::: ...|:.....:|.|||||::|||.:|:|| ..:|.:...||||:||||.|..|.:.
Mouse   284 TKIFWLTTRQGLPFTIFQGGMPRASYGDRHCISV-VHNGQQTAFDFTSRVIDFTVLSEADPAAAF 347

  Fly   340 DVAEVLVVLLEEELCAYDLTDPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQD 404
            |....||||.||||...||..|....::.|||.|:|.||:||::..|.:...::|.|:.||..|:
Mouse   348 DDPYALVVLAEEELVVIDLQTPGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQN 412

  Fly   405 IDYSNISWPITGGT--LPDNLEESVEEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSS 467
            ..:|.:.|||.|||  .|...:.          ::||||||||:|:|||.:||.|:.:|...|..
Mouse   413 SHFSTMEWPIDGGTSLAPPPPQR----------DLLLTGHEDGTVRFWDASGVCLRLLYKLSTVR 467

  Fly   468 IFGSESDFRDDAAADMSAEQVDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQ 532
            :|.:::    |.:.::.|:..||. ||.||.|.||||||||||.::||..|..:|.|.|.|||||
Mouse   468 VFLTDT----DPSENLIAQGEDEW-PPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQ 527

  Fly   533 IVIADFIDLPEKVSLKYISMNLVSDRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVL 597
            :::.:..|...:.:::.:..:|:.|::|:.||||::|..|...:..||      |.....::|..
Mouse   528 VLVLELNDEAAEHAVEQVEADLLQDQEGYRWKGHERLAARPGPVCFEA------GFQPFVLVQCQ 586

  Fly   598 PPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLR 662
            |||.:|.:||.:.|.||:.||:||..|||.:....||.:|||:|:|.......|||.||.|||||
Mouse   587 PPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLR 651

  Fly   663 ESFRKLRKGRSTRTNQSNQVPT------------------------------------------T 685
            :|||::|:.|.:...:....||                                          .
Mouse   652 QSFRRMRRSRVSSHKRRPGGPTGEVRPQAQSSHLQDHTALPQDLNPDQAQAQAVNIKAERTGLQN 716

  Fly   686 LEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVSVFLLHLPPAQTA 750
            :|..||:|:||||.|:|.....||.|.||.||:.:.:...|:||:.||..||..|.|.:|||:
Mouse   717 MELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTNGGTVYAFSLRVPPAE-- 779

  Fly   751 ATAVPSASGNAPPHMPRR----ISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQ-------LNAG 804
                            ||    :.|:.||||||.||||||||.:.|....|:.:       |:..
Mouse   780 ----------------RRTDEPVRAEQAKEIQLMHRAPVVGILVLDGHNVPLPEPLEVAHDLSKS 828

  Fly   805 ENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRI---HFGSFSCRISPETLQSMH 866
            .:....|::|:.||||||||:||::....|.||||.||:|:||:   ||||
Mouse   829 PDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVGVAHFGS-------------- 879

  Fly   867 GCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPELKRQLNAAAVRR 931
             |                         |.:.|.|..|..|||:|||.|:|:|.||.|:..:.:||
Mouse   880 -C-------------------------RAEDYGEHHLAVLTNLGDIQVVSMPLLKPQVRYSCIRR 918

  Fly   932 EDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVV 974
            ||::|::|..||..|:..|::|.||.:|.:|:|..:|:|..:|
Mouse   919 EDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLV 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_523439.2	WD40 repeat	39..78	CDD:293791	20/38 (53%)
		WD40 repeat	84..126	CDD:293791	12/61 (20%)
		WD40 repeat	131..174	CDD:293791	15/43 (35%)
		WD40 repeat	188..224	CDD:293791	16/50 (32%)
		LLGL	268..>338	CDD:462446	32/70 (46%)
Llgl2	NP_001239461.1	WD40	<29..261	CDD:441893	79/268 (29%)
		WD40 repeat	35..67	CDD:293791	19/31 (61%)
		WD40 repeat	76..120	CDD:293791	7/43 (16%)
		WD40 repeat	127..153	CDD:293791	10/33 (30%)
		WD40 repeat	192..228	CDD:293791	11/35 (31%)
		LLGL	271..372	CDD:462446	44/101 (44%)