DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)gl and lgl-1

DIOPT Version :9

Sequence 1:NP_001245801.1 Gene:l(2)gl / 33156 FlyBaseID:FBgn0002121 Length:1161 Species:Drosophila melanogaster
Sequence 2:NP_508169.2 Gene:lgl-1 / 180435 WormBaseID:WBGene00018987 Length:941 Species:Caenorhabditis elegans


Alignment Length:1069 Identity:215/1069 - (20%)
Similarity:405/1069 - (37%) Gaps:257/1069 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLKFIRGK-GQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQ 64
            :|:|||.| ..:|  :.|.::: ...:.:..:.||  ....:|:|.....:.||::.|.:..:|.
 Worm     4 ILRFIRSKFYHEP--EEHAIEQ-YAVFDEGNRGGF--TSDVVAFDYHNGCVVIGSKNGEVTFYGY 63

  Fly    65 PGVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWEPVGATLLPIKTLPFDGKLK 129
            .|..  ...:|..:|.::..::         .|..:::...|:|.:  |..::||...  ||.:.
 Worm    64 RGAS--WTVSLSKDSENKARIE---------HIFFISSNIALVLCD--GQLIIPIHIK--DGVIT 113

  Fly   130 KVSSLCCSLSKDLLWIGTEGGNIYQLDLHTF----------------TIKEPVIYHDVVLEQVPP 178
            |...|..:.:....|..|   ::.:|...||                |:|..|:......|:..|
 Worm   114 KKEELRFNENHKSKWDIT---HVQKLSDDTFALVFSMNNTIYRIKSKTLKSEVLVKAEDFEKWLP 175

  Fly   179 AYKLNPGAIESIRQLPNSPSKLLVAYNRGLCV-------------LWDFESASVQRAYIAPGHGQ 230
                :...:.||..||..||.|::....| ||             |.::|..::|:.:.:....:
 Worm   176 ----DDTELASITCLPEKPSILMLIAENG-CVGVFNESQFVMKTSLRNYEDEAIQKLHWSSEKKK 235

  Fly   231 SVGLTVNFEGSEFTWYHADGSYATWSI----DNPEPPSNVNYV---PYGPDPCKSINRL---YKG 285
            :|...::          .:..|..|..    |.......||..   .:||.||..|...   ...
 Worm   236 NVAFGIS----------CNNKYTKWEFTVGKDCQISAQEVNVYSANQFGPYPCHQIRHFSVCADA 290

  Fly   286 KRRSNDVIVFSGGMPRSAYGDHNCVSV-HASDGHKVCLDFTSKVIDFFVTFENNRDVAEVLVVLL 349
            ...:.:.:::.||.....|.|.:.::: |.....|  |:.:|:::.......:..|..:..|||:
 Worm   291 SDPNENFLIYQGGKSSGKYDDRDLITISHGDFVEK--LELSSEIVGIVGVSGSYEDCKKSGVVLI 353

  Fly   350 --EEELCAYDLTDPNICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDE--QDIDYSNI 410
              :.|:...||...::..::..:..|::.|..|.:..|.|:.::|:..:..|...  :....|..
 Worm   354 CTKCEIIGIDLERESLNMMQPKHFLSINNSTPTTHSRAIEIEENVWNRLESASKSYWETNQMSTR 418

  Fly   411 SWPITGGTLPDNLEESVEEDA----TKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGS 471
            .||:       |.::.:..||    ....::.|:||.:|::..|...||.:..:...:||..|..
 Worm   419 DWPL-------NFQKKIVTDANHQRASYRQVYLSGHSNGNICIWSSGGVGMSLMLVIRTSLEFDG 476

  Fly   472 ESDFRDDAAADMSAEQVDE-GEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVI 535
            .|.|.::   |.:....|| .|.|.||.||:||:.||..:.:.::.|.||:|.:|.....|.:::
 Worm   477 ASSFDNE---DSNYYNSDEKPEKPVRKIGLYDPFDDDEEMCITRVHFDPKSGIVIGTNRGGYVLM 538

  Fly   536 ADFID---------------------------LPEKVSLKY---ISMNLVSDRDGFVWKGHDQLN 570
            .:..|                           .|.|..|||   ..:.|.::.|           
 Worm   539 YELWDSARTLTHWEATPISCNNSPPDTRKRALKPRKAELKYNAGYQIRLKNESD----------- 592

  Fly   571 VRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFH 635
                      :|.         |..:.|...||.:.....:..::.|:..|:|:.|. ||..:.:
 Worm   593 ----------LPL---------VFSMHPSHRITDIVYLHKYHCLAVGSNFGIVMLDV-NFGYLVY 637

  Fly   636 RCTLNP--NDLTG-AGEQLSRRKSFKKSLRESFRKLRKGRSTRTNQSNQVPTTL-----EARP-- 690
            ..:.|.  ||.:. :..|..|.||.|||||::||:.:||..|..:....|.::.     |..|  
 Worm   638 ANSFNDDNNDSSNVSANQFQRFKSLKKSLRKTFRRKKKGTETLMDSGGAVASSSNHVQHETSPKR 702

  Fly   691 ----------VERQIEAR-------CADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVS 738
                      :||.||||       |..:.....|.||...:         .|.| ...|...:.
 Worm   703 IDDFEEEEVFMERPIEAREELGVLDCYAENSKGTVTCLRMMR---------FPVL-DDKNVDDII 757

  Fly   739 VFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQLNA 803
            ...||.......|.:.....      :.....|:..|::.:.|:.|||.:.|.::.|        
 Worm   758 AVGLHEGSVYFYAISEHDVG------LRMTFKAEQIKKLSIPHKQPVVNLDITNEEG-------- 808

  Fly   804 GENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRISPETLQSMHGC 868
              ..|...|:::.:|||.::::...:...:.||:||.||.:|:                      
 Worm   809 --YFSASTRIVVITEEQLRIYNCQPMVKRDSYKITALEGLKIK---------------------- 849

  Fly   869 SPTKSTRSHGDGEADPNISGSLA--VSRGDVYN-ETALICLTNMGDIMVLSVPELKRQLNAAAVR 930
                              :|.:|  :::.:..| |:.::.:.|.|.:.|.||.:.....:...:.
 Worm   850 ------------------NGMVARILNKKNSNNFESFVVLVANDGSLRVHSVQKASSFESRKFID 896

  Fly   931 REDINGVSSLCFTNSGEALYMMSSSELQR 959
            ..|:..::|.|.:..|:..:::.||||||
 Worm   897 PIDVMALNSSCLSRDGDVAFLIKSSELQR 925

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)glNP_001245801.1 WD40 repeat 39..78 CDD:293791 8/38 (21%)
WD40 repeat 84..126 CDD:293791 6/41 (15%)
WD40 repeat 131..174 CDD:293791 9/58 (16%)
WD40 repeat 188..224 CDD:293791 13/48 (27%)
LLGL 268..>338 CDD:285555 13/76 (17%)
lgl-1NP_508169.2 LLGL 273..364 CDD:369834 18/92 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166033
Domainoid 1 1.000 98 1.000 Domainoid score I4519
eggNOG 1 0.900 - - E1_KOG1983
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0.928771 Normalized mean entropy S6106
OMA 1 1.010 - - QHG48039
OrthoDB 1 1.010 - - D113391at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10241
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
109.770

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