DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gl and stxbp5

DIOPT Version :9

Sequence 1:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	XP_012819238.1	Gene:	stxbp5 / 100488413	XenbaseID:	XB-GENE-1012360	Length:	1151	Species:	Xenopus tropicalis

Alignment Length:	1141	Identity:	301/1141 - (26%)
Similarity:	469/1141 - (41%)	Gaps:	320/1141 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASEL 83
            ||.:.|...||.:||||::|||||:|||.|::|||||||||::||:||||.|.||   ::.|:.:
Frog    41 LQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAIGTQTGALRLFGRPGVECYCQH---DSGAAVI 102

  Fly    84 NVQLLEWVYGTGRILSLTAANQLILW---EPVGATLLPIK---------TLPFDGKLKKVSSLCC 136
            .:|.|   ...|.::|....:.|.||   :...|.|..:|         .|||..|
Frog   103 QLQFL---INEGALVSALTDDTLHLWNLRQKRPAVLHSLKFSRERITFCHLPFQSK--------- 155

  Fly   137 SLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLPNSPSKLL 201
                 .|::|||.|||:.:::.:||:...||..:..:|.   :.|.:||.:..|...|....|||
Frog   156 -----WLYVGTERGNIHIVNVESFTLSGYVIMWNKAIEL---SSKSHPGPVVHISDNPMDEGKLL 212

  Fly   202 VAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGSEFTWYHADGSYATWSIDNPEPPSNV 266
            :.:..|:.||||.:|......|.......||..  :.||.:|...|:||:...|::.:|.....
Frog   213 IGFESGIVVLWDLKSKKADYRYTYDEAIHSVAW--HHEGKQFICSHSDGTLTIWNVRSPAKCIQ- 274

  Fly   267 NYVPYG--------PDPCKSINRL-YKGKRRSNDVIVFSGGMPRSAYGDHNCVSV-HASDGHKVC 321
            ..||:|        |:|||.|.:: ||..|..:..|:.|||:.....|...|::| |......:.
Frog   275 TIVPHGKQIKDGKKPEPCKPILKVEYKTTRYGDPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLE 339

  Fly   322 LDFTSKVIDFFVTFE----NNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPYLHSVHASAVT-C 381
            :|:  .::||....|    |:......:|||||::|...||........:.||..|:|.|.|| |
Frog   340 MDY--PIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVVIDLAQNGYPIFENPYPLSIHESPVTCC 402

  Fly   382 NYLAS---EVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEEDATKLY-EILLTGH 442
            .|.|.   :::.::|....|   ::...||...|||:||..         ...|:.| ||::|||
Frog   403 EYFADCPVDLIPALYSVGAR---QKRQGYSKKEWPISGGNW---------GVGTQSYPEIIITGH 455

  Fly   443 EDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKSGLFDPYSDD 507
            .|||:||||.:.:.|:.:|..||:.:| .:|..:||..   |.:.|||           |||
Frog   456 ADGSIKFWDASAITLQVLYKLKTAKVF-EKSRNKDDKP---STDIVDE-----------DPY--- 502

  Fly   508 PRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISM----------NLVS------ 556
               |::.|::||::..|.|.|.:..::|..|  ..::|:.:.:||          :|.|
Frog   503 ---AIQMISWCPESRVLCVAGVSAHVIIYRF--SKQEVTTEVVSMLEVRLLYEINDLESPDIEQV 562

  Fly   557 -------DRDGFVWKGHDQ---------------LNVRSNLLDGEAIPTTERGVNISGVLQVL-- 597
                   :....|::.|..               |.|:|..|...|      |..:..|:|::
Frog   563 PTPSGGPNSQPIVFQSHPSTSSSSSDGIRDNVPCLRVKSTALKQSA------GYQVELVIQLVWV 621

  Fly   598 ---PPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSR-----R 654
               ||..||.:|:.:::|||..|..:|:.:.|:.....:.:..|:   :|.|:.:...|     |
Frog   622 SGEPPQQITSLAVNSAYGLVVFGNCNGIAIVDYIQKAVLLNLSTV---ELYGSNDPYQRQPRSPR 683

  Fly   655 KSFKKS------LRES-----------------------------FRKLR-KGRS---------T 674
            |:.:.|      :.||                             ..|:: |||.         .
Frog   684 KTRQPSGAGLSDINESTVASEDRCKSPTSGCTSNSSDDEQTKSKFIEKVKIKGRRFSKAIVTDLA 748

  Fly   675 RTNQSNQVPTTLEARPV------------ERQIEARCADDGLGSMVRCLLFAKTYVTNVNI-TSP 726
            :.::...:||.|:...|            .|.......|......:..|.|.:|:....:: |||
Frog   749 KMSRKLSLPTELKPELVPFLDVRDNSFSRSRSSSVTSIDKESREAISSLHFCETFTRKPDVSTSP 813

  Fly   727 TLWSATNASTVSVFLLHLPPA------------------------------QTAATAVPSASGN- 760
            .||..|...||.|.:|:|||.                              .|....:|.||.:
Frog   814 CLWVGTTLGTVLVIVLNLPPGGEQRLLQPVIVSPSGTILRLKGAILRMSFLDTLGALIPPASESW 878

  Fly   761 APPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQLNAGENGSPPHRVLIASEEQFKVFS 825
            ..|::|.    ....:.:||.|.||        :.||.......||    ...:|.||:|.||.|
Frog   879 REPNVPE----DKDDKDRLKKRRPV--------SVSPSSSQEISEN----QYAVICSEKQAKVIS 927

  Fly   826 LPQLKPINKYKLTANEGARIRRIHFGSFSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSL 890
            ||....|  |||                                               ||:.:.
Frog   928 LPSQNCI--YKL-----------------------------------------------NITETS 943

  Fly   891 AVSRGDVY---NETALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMM 952
            .|.|||:.   |.|.|.|....|.||..|:|.|:..|:...:...::....:.||||:|:|||::
Frog   944 FVLRGDIVSMSNSTCLACFCANGHIMTFSLPSLRPLLDVNYLPLTNMRIARTFCFTNNGQALYLV 1008

  Fly   953 SSSELQRIALATSRVVQPTGVVPVEPLENEESVLEE 988
            |.:|:|||..:.            |..||.:.:|.|
Frog  1009 SPTEIQRITYSQ------------ETCENLQEMLGE 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	26/38 (68%)
		WD40 repeat	84..126	CDD:293791	13/53 (25%)
		WD40 repeat	131..174	CDD:293791	11/42 (26%)
		WD40 repeat	188..224	CDD:293791	11/35 (31%)
		LLGL	268..>338	CDD:285555	23/83 (28%)
stxbp5	XP_012819238.1	WD40	61..>283	CDD:392136	81/247 (33%)
		WD40 repeat	61..94	CDD:293791	24/32 (75%)
		WD40 repeat	102..140	CDD:293791	9/40 (23%)
		WD40 repeat	145..191	CDD:293791	16/62 (26%)
		WD40 repeat	199..235	CDD:293791	11/35 (31%)
		WD40 repeat	240..275	CDD:293791	10/37 (27%)
		LLGL	275..383	CDD:369834	32/109 (29%)
		R-SNARE_STXBP5	1084..1144	CDD:277246
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10877
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000