Protein Alignment l(2)gl and llgl1

DIOPT Version :9

• Sequence 1: NP_001245801.1
• Gene: l(2)gl / 33156
• FlyBaseID: FBgn0002121
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: XP_002935892.2
• Gene: llgl1 / 100486472
• XenbaseID: XB-GENE-868457
• Length: 1052
• Species: Xenopus tropicalis
• Alignment Length: 1143
• Identity: 403/1143 - (35%)
• Similarity: 619/1143 - (54%)
• Gaps: 187/1143 - (16%)

  Fly     1 MLKF-IRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQ 64
            |:|| .|.:|..|  .|.:::::|||:.||.:||||::||:||:||:|::||||.::||:|::|.
 Frog     1 MMKFRFRRQGHDP--QREKIKQELFAFNKTVEHGFPNQPSSLAFDPLLRIMAIGAKSGAVKIYGA 63

  Fly    65 PGVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILW-----------EPVGATLLP 118
            ||||..|.|   .::|:   |..:.::.|.||:|||...|.:.||           |...:.|||
 Frog    64 PGVEFTGLH---KDTAT---VTQMHFLPGQGRLLSLLDDNTMHLWELQQKDGSSHLEETRSFLLP 122

  Fly   119 IKTLPFD-----GKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTF-TIKEPVIYHDVVLEQVP 177
            .|. .||     ....:|:.:..:.|.::..:|||||.:|.:.:.:. .::|..:..|.:::.:|
 Frog   123 GKP-GFDCANSPPSFTRVTVILITASCEVAGLGTEGGGVYFIQIPSLKLLEEKTLLQDEIVKSLP 186

  Fly   178 PAYKLNP--GAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEG 240
            ..|:...  |.:||:::.|.....:|:.|:|||.||||.|...|:..::  |:.|...:....:|
 Frog   187 EEYRCGKTLGPVESLQEHPCQRGTILIGYSRGLVVLWDQEGRKVEHLFL--GNQQLESVFWGRKG 249

  Fly   241 SEFTWYHADGSYATWSIDNPEPPSN---VNYVPYGPDPCKSINRL-YKGKRRSNDVIVFSGGMPR 301
            :.|...|:||.|..|...:....::   .:.:||||.|||:||:: ::.....|..|:|||||||
 Frog   250 TSFISSHSDGGYMVWEAASDSSTTSQPVTSKIPYGPFPCKAINKIQWRSSSSGNPYIIFSGGMPR 314

  Fly   302 SAYGDHNCVSVHASDGHKVCLDFTSKVIDFF----VTFENNRDVAEVLVVLLEEELCAYDLTDPN 362
            ::|||.:||:: ....:.|.|||||:|:|||    :..|::.|....||||:||||...||..|.
 Frog   315 ASYGDRHCVTI-LQGQNLVTLDFTSRVVDFFTVCPLKSEDDSDNPTALVVLVEEELVVIDLQTPG 378

  Fly   363 ICAIKAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESV 427
            ...:..|||..:|:||:||.|..|.|...::|.|:.||::|:..:|:::|||.||.   ||   .
 Frog   379 WPTVPTPYLAPLHSSAITCAYHISNVTTKLWERIISAGEQQNPQFSSVNWPIDGGR---NL---A 437

  Fly   428 EEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGE 492
            ||.|.:  .:||||||||:|:|||.:||.|:|:|...|:.||.::.|..:.     ..:..||..
 Frog   438 EEPAQR--GLLLTGHEDGTVRFWDASGVALRPLYKLSTAGIFQTDCDHNES-----FNQSNDEEW 495

  Fly   493 PPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKV--SLKYISMNLV 555
            |||||.|.||||||||||.::|||.|..:|:::|.|||||:::.|..|  |||  ::...:::|:
 Frog   496 PPFRKVGCFDPYSDDPRLGIQKIALCKYSGKMLVAGTAGQVLVMDLND--EKVEHTINVATVDLL 558

  Fly   556 SDRDGFVWKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTAH 620
            .:|:||.|||||:|..|:..|      ..:.|.....::|.:|||::|.:||.:.|.||:.||:|
 Frog   559 QEREGFTWKGHDRLTPRNGSL------FFQPGFQTITLVQCMPPAAVTAVALHSEWNLVAFGTSH 617

  Fly   621 GLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGR------------S 673
            |..|||:....||..||||:|||.......|||.||.|||||:|||::||.|            .
 Frog   618 GFGLFDYHRRSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRPNTGSPP 682

  Fly   674 TRTNQSNQV------PTTLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSAT 732
            :|..::|..      |..|:..||:|:||.|.|||.|..:||||.||.|::.:.....||:|:.|
 Frog   683 SRLQEANAQLAEQAGPHDLDIAPVQRRIEPRSADDSLSGVVRCLYFADTFLRDAIHHGPTMWAGT 747

  Fly   733 NASTVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSP 797
            |:.:|..:.|.:|..:..:              .|...|.|.|||||.||||||.|::.|..|:|
 Frog   748 NSGSVFAYALEVPSREKLS--------------DRSAEAVLGKEIQLMHRAPVVSIAVLDGRGNP 798

  Fly   798 VDQ-------LNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSC 855
            :.:       |....:....|.|||:||||||||:||::....|:||||:||.|:|::...:|:.
 Frog   799 LPEPFEVSQDLAKAPDMQGTHSVLISSEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFTS 863

  Fly   856 RISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPEL 920
            ..|                                     |.|:|..|.||||:|||.|.:||.|
 Frog   864 ATS-------------------------------------DDYSENCLACLTNLGDIHVFTVPGL 891

  Fly   921 KRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVV----PVEPLE- 980
            :.|:....:|:|||:|::|..||..|:..|::|.||.:|.:|:...:.:|..:|    |.:||.
 Frog   892 RPQVRYDCIRKEDISGIASCVFTKYGQGFYLISPSEFERFSLSAKNITEPVCLVEFDRPHDPLHF 956

  Fly   981 -------------NEESVLEENDA-ENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSV 1031
                         |...:|.:::| :...|...|:.:...    :||.:
 Frog   957 SNKMTPSPKGNQANGTHILRDSEASQQATEGNGCERMAEF----SPSPL---------------- 1001

  Fly  1032 QQVNGVNISNSPNQANETISSSIGDITVDSVRDHLNMT 1069
                     :||..:.:|...:.|||||:.|||.|..|
 Frog  1002 ---------DSPMNSMDTTLDTTGDITVEDVRDILGST 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	20/38 (53%)
		WD40 repeat	84..126	CDD:293791	17/57 (30%)
		WD40 repeat	131..174	CDD:293791	10/43 (23%)
		WD40 repeat	188..224	CDD:293791	14/35 (40%)
		LLGL	268..>338	CDD:285555	34/74 (46%)
llgl1	XP_002935892.2	WD40 repeat	37..69	CDD:293791	19/31 (61%)
		WD40 repeat	78..116	CDD:293791	11/37 (30%)
		LLGL	279..379	CDD:400597	46/100 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	375	1.000	Domainoid score	I863
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31220
Inparanoid	1	1.050	656	1.000	Inparanoid score	I771
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		otm47732
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060