Protein Alignment HSPB1 and Hsp26

DIOPT Version :9

• Sequence 1: NP_001531.1
• Gene: HSPB1 / 3315
• HGNCID: 5246
• Length: 205
• Species: Homo sapiens
• Sequence 2: NP_001287000.1
• Gene: Hsp26 / 39075
• FlyBaseID: FBgn0001225
• Length: 208
• Species: Drosophila melanogaster
• Alignment Length: 210
• Identity: 64/210 - (30%)
• Similarity: 87/210 - (41%)
• Gaps: 46/210 - (21%)

Human    12 RGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPL--------------PPAA 62
            |.|.::.....:||||                          ||.||              .|..
  Fly    17 RSPIYELGLGLHPHSR--------------------------YVLPLGTQQRRSINGCPCASPIC 55

Human    63 IESPAVAAPAYSRALSRQLSSGVSEIRHTA-DRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEE 126
            ..|||....|..|.::.:.........|.. |.::|.:||..|.|.||.||..|..:.:.|||||
  Fly    56 PSSPAGQVLALRREMANRNDIHWPATAHVGKDGFQVCMDVAQFKPSELNVKVVDDSILVEGKHEE 120

Human   127 RQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK-LATQSNEITIPVTFESRAQ 190
            |||:||:|.|.|.|:|.:|.|....||.|.||.:|.|||..|.|: :..:|.|..|.:.....|.
  Fly   121 RQDDHGHIMRHFVRRYKVPDGYKAEQVVSQLSSDGVLTVSIPKPQAVEDKSKERIIQIQQVGPAH 185

Human   191 LGGPEAAKSDETAAK 205
            |.    .|::|:..|
  Fly   186 LN----VKANESEVK 196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPB1	NP_001531.1	Interaction with TGFB1I1. /evidence=ECO:0000250	70..205		49/136 (36%)
		ACD_HspB1_like	84..169	CDD:107230	38/85 (45%)
Hsp26	NP_001287000.1	metazoan_ACD	85..163	CDD:107247	37/77 (48%)
		IbpA	<87..179	CDD:223149	42/91 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6558
SonicParanoid	1	1.000	-	-		X5925
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850