Protein Alignment HSPB1 and l(2)efl

DIOPT Version :9

• Sequence 1: NP_001531.1
• Gene: HSPB1 / 3315
• HGNCID: 5246
• Length: 205
• Species: Homo sapiens
• Sequence 2: NP_001261156.1
• Gene: l(2)efl / 37744
• FlyBaseID: FBgn0011296
• Length: 187
• Species: Drosophila melanogaster
• Alignment Length: 203
• Identity: 77/203 - (37%)
• Similarity: 105/203 - (51%)
• Gaps: 43/203 - (21%)

Human    19 FRDWYPH-------SRLFDQAF--GLPRLPEEWSQWLGGSSWP-----GYVRPLPPAAIESPAVA 69
            ||||:..       |||.||.|  ||.|.....|.|   :|.|     ||:||.
  Fly     8 FRDWWDELDFPMRTSRLLDQHFGQGLKRDDLMSSVW---NSRPTVLRSGYLRPW----------- 58

Human    70 APAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYI 134
               ::.:|.:|.|.  |.:...::::.|.|||..|:|.|:|||..|..|.:.|||||:||||||:
  Fly    59 ---HTNSLQKQESG--STLNIDSEKFEVILDVQQFSPSEITVKVADKFVIVEGKHEEKQDEHGYV 118

Human   135 SRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEA--- 196
            ||.|:|:|.||..|:|..|:||||.:|.||::|||..|.....|..:.:|      ..||.:
  Fly   119 SRQFSRRYQLPSDVNPDTVTSSLSSDGLLTIKAPMKALPPPQTERLVQIT------QTGPSSKED 177

Human   197 -AKSDETA 203
             ||..||:
  Fly   178 NAKKVETS 185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPB1	NP_001531.1	Interaction with TGFB1I1. /evidence=ECO:0000250	70..205		56/138 (41%)
		ACD_HspB1_like	84..169	CDD:107230	42/84 (50%)
l(2)efl	NP_001261156.1	metazoan_ACD	71..153	CDD:107247	41/81 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101545
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6558
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750