Protein Alignment HSPB1 and Hsp22

DIOPT Version :9

• Sequence 1: NP_001531.1
• Gene: HSPB1 / 3315
• HGNCID: 5246
• Length: 205
• Species: Homo sapiens
• Sequence 2: NP_001027114.1
• Gene: Hsp22 / 3772576
• FlyBaseID: FBgn0001223
• Length: 174
• Species: Drosophila melanogaster
• Alignment Length: 195
• Identity: 54/195 - (27%)
• Similarity: 81/195 - (41%)
• Gaps: 58/195 - (29%)

Human    27 RLFDQAFGLPRL----------PEEWS-----QWLGGSSWPGYVRPLPPAAIESPAVAAPAYSRA 76
            |:.::...:|||          |..||     .|...:.|... ...|||.:..
  Fly     9 RMAEEMARMPRLSSPFHAFFHEPPVWSVALPRNWQQIARWQEQ-EFAPPATVNK----------- 61

Human    77 LSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKD-GVVEITGKHEERQDEH-GYISRCFT 139
                            |.::::|||..::  ||.||..| .||.:.||.|:::.|. ||.||.|.
  Fly    62 ----------------DGYKLTLDVKDYS--ELKVKVLDESVVLVEGKSEQQEAEQGGYSSRHFL 108

Human   140 RKYTLPPGVDPTQVSSSLSPEGTLTVEAPMP---KLATQSNEITIPVTFESRAQLGGPEAAKSDE 201
            |::.||.|.:..:|:|:||.:|.||:..|.|   :...:..|:||..|        |..|.||.|
  Fly   109 RRFVLPEGYEADKVTSTLSSDGVLTISVPNPPGVQETLKEREVTIEQT--------GEPAKKSAE 165

Human   202  201
              Fly   166  165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPB1	NP_001531.1	Interaction with TGFB1I1. /evidence=ECO:0000250	70..205		42/137 (31%)
		ACD_HspB1_like	84..169	CDD:107230	31/86 (36%)
Hsp22	NP_001027114.1	IbpA	17..154	CDD:223149	46/166 (28%)
		metazoan_ACD	61..138	CDD:107247	31/105 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810