DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cda4 and ChLD3

DIOPT Version :9

Sequence 1:	NP_728468.1	Gene:	Cda4 / 33144	FlyBaseID:	FBgn0052499	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_609806.1	Gene:	ChLD3 / 35002	FlyBaseID:	FBgn0032598	Length:	577	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	170/473 - (35%)
Similarity:	251/473 - (53%)	Gaps:	61/473 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 CRRFYQCVDGYPYLNRCPSGLFFDDVQKFCTFKDEA-KCGPLPTTPAPA---------------- 90
            |.:::.|:||..:..:|..||.||.|::.|.||... .|.....||||.
  Fly   111 CAKYFLCLDGEVFEFKCSEGLLFDVVRQICDFKANVDNCDVSAETPAPKPLLEMADCADEYQLGC 175

  Fly    91 ----------------------------TEAPADTAQRCNTENCALPYCFCSKDGTQIPGDLEPE 127
                                        .|...:.|..|:...|.||.||||||||||||.|..:
  Fly   176 ADGTCLPQEYFCDGSVDCPDGSDEGWCDVEHDPNAAGACDPRKCHLPQCFCSKDGTQIPGSLPAQ 240

  Fly   128 KIPQIIMLTFDGAVNLNNYQHYQKI-FDGKRKNPNGCLIRGTFFMSHEYSNYQQIQHLGYYGHEI 191
            .:||:|:||||.|:|.:|::.:.|: |...|:|||||.|:|||::||.::|||.:|.|...||||
  Fly   241 SVPQMILLTFDDAINHDNWELFSKVLFTQHRRNPNGCPIKGTFYVSHPFTNYQYVQKLWNDGHEI 305

  Fly   192 GTESIS----QQQGLQDKGYEEWVGEMIGMREILRHFANVSVNDVVGMRAPFLKPGRNTQYKVLE 252
            ...|::    :....::...|:|..||:|...|:..||.|.:.::.|||.|||:.|.|.|:.:::
  Fly   306 AVHSVTHRGPEMWWSKNATIEDWFDEMVGQANIINKFAAVRMEEIRGMRVPFLRVGWNRQFLMMK 370

  Fly   253 DFGYIYDSSITVPPVPVPVWPYTLDYKISHECK--SGTCPSRTFPGVWEVPLNTHYVEGYEGGHC 315
            :||::||||:..|....|:||||||||:.|.|.  :..||||::||:||:.:|...|..|   .|
  Fly   371 EFGFVYDSSMVAPHSNPPLWPYTLDYKMPHSCTGVNQNCPSRSYPGIWELVMNQLEVGEY---MC 432

  Fly   316 PYLDQCVLHNLDEEEVFQWLQEDFSRYYEQNKAPYMMPFHTNWFQTKPLENGLHKFLDWALELPD 380
            ..:|.|..| |..|:|::.|..:|.|:|..|:||:.:.||:.||:.....|...||||...:|||
  Fly   433 GMVDTCPPH-LSGEDVYRMLTHNFKRHYLSNRAPFGLYFHSTWFKKVDYLNAFLKFLDDLQKLPD 496

  Fly   381 VYILTVTQMLQYVTDPKELRDVSQIESWKCD-KSVSVAPKPCNIWQTCALPFKIPEQNLTDTRYM 444
            |:.:|..|.:|::..|.....:.|.|||.|. |.:....:.||....|    |:..:.|.:.|:.
  Fly   497 VFFVTNQQAIQWMRHPTPSNQLHQFESWHCQPKDLDPHEQVCNTPNVC----KVRSRVLQEDRFF 557

  Fly   445 ETCRECPNVYPWLGDAGG 462
            .||.|||..|||:.:..|
  Fly   558 YTCMECPAQYPWIRNEFG 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cda4	NP_728468.1	CBM_14	33..80	CDD:279884	13/37 (35%)
Cda4	NP_728468.1	CE4_CDA_like_1	130..396	CDD:200596	111/272 (41%)
ChLD3	NP_609806.1	CBM_14	<111..149	CDD:279884	13/37 (35%)
		LDLa	168..202	CDD:238060	0/33 (0%)
		CE4_CDA_like_1	243..512	CDD:200596	111/272 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060206at2759
OrthoFinder	1	1.000	-	-		FOG0003270
OrthoInspector	1	1.000	-	-		otm14253
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4295
	6	6.020