DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cda4 and CHI3L2

DIOPT Version :9

Sequence 1:	NP_728468.1	Gene:	Cda4 / 33144	FlyBaseID:	FBgn0052499	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_003991.2	Gene:	CHI3L2 / 1117	HGNCID:	1933	Length:	390	Species:	Homo sapiens

Alignment Length:	239	Identity:	52/239 - (21%)
Similarity:	82/239 - (34%)	Gaps:	74/239 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 IPGDLEPEKIPQ----IIMLTFDGAVNLNNYQHYQKIFDGKRKNP-----NGCLIRGTFFMSHEY 175
            |....:.||:.:    |.:|:||              |.|..:.|     |..|.:|  :.....
Human   191 IDNSYQVEKLAKDLDFINLLSFD--------------FHGSWEKPLITGHNSPLSKG--WQDRGP 239

  Fly   176 SNYQQIQH-LGYYGHEIGTESISQQQGLQDKGYEEWVGEMIGMREILRHFANVSVNDVVGMRAPF 239
            |:|..::: :||:.|: |..|.....|:...|:.               |...|....||  ||.
Human   240 SSYYNVEYAVGYWIHK-GMPSEKVVMGIPTYGHS---------------FTLASAETTVG--APA 286

  Fly   240 LKPGRNTQYKVLEDFGYI--YD----------SSITVPPVPVPV----WPYTLDYKISHECKSGT 288
            ..||  ....:.|..|::  |:          :.:....||..|    |....|.| |.|.|...
Human   287 SGPG--AAGPITESSGFLAYYEICQFLKGAKITRLQDQQVPYAVKGNQWVGYDDVK-SMETKVQF 348

  Fly   289 CPSRTFPG--VWEVPLNTHYVEGYEGGHC---PY-LDQCVLHNL 326
            ..:....|  :|.:.:     :.:.|..|   || |.|.|..:|
Human   349 LKNLNLGGAMIWSIDM-----DDFTGKSCNQGPYPLVQAVKRSL 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cda4	NP_728468.1	CBM_14	33..80	CDD:279884
Cda4	NP_728468.1	CE4_CDA_like_1	130..396	CDD:200596	49/229 (21%)
CHI3L2	NP_003991.2	GH18_chitolectin_chitotriosidase	29..387	CDD:119351	51/237 (22%)
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	75..76
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	102..105
		Chitooligosaccharide binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01258	210..213		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156421
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930