DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cda4 and CHI3L1

DIOPT Version :9

Sequence 1:NP_728468.1 Gene:Cda4 / 33144 FlyBaseID:FBgn0052499 Length:486 Species:Drosophila melanogaster
Sequence 2:NP_001267.2 Gene:CHI3L1 / 1116 HGNCID:1932 Length:383 Species:Homo sapiens


Alignment Length:311 Identity:64/311 - (20%)
Similarity:99/311 - (31%) Gaps:100/311 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 PQIIMLTFDGAVNLNNYQHYQKIFDGKRKNPNGCLIRGTFFMS-------HE---------YSNY 178
            |.:..|...|..|..: |.:.||....:.       |.||..|       |.         |...
Human    88 PNLKTLLSVGGWNFGS-QRFSKIASNTQS-------RRTFIKSVPPFLRTHGFDGLDLAWLYPGR 144

  Fly   179 QQIQHLGYYGHEIGTESISQ-QQGLQ---------------DKGYEEWVGEMIGMREILRHFANV 227
            :..||......|:..|.|.: |.|.:               |..|:        :.:|.:|...:
Human   145 RDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYD--------IAKISQHLDFI 201

  Fly   228 SV---------NDVVGMRAPFLK------PGR--NTQYKVLEDFGYIY----DSSITVPPVPVPV 271
            |:         ....|..:|..:      |.|  ||.|.|    ||:.    .:|..|..:|...
Human   202 SIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAV----GYMLRLGAPASKLVMGIPTFG 262

  Fly   272 WPYTLDYKISHECKSGTCPSRT-FPGVWEVPLNTHYVEGYEGGHCPYLDQCVLHNLDEEEV---- 331
            ..:||   .|.|...|...|.. .||.:.....|  :..||  .|.:|....:|.:..::|    
Human   263 RSFTL---ASSETGVGAPISGPGIPGRFTKEAGT--LAYYE--ICDFLRGATVHRILGQQVPYAT 320

  Fly   332 --FQWLQEDFSRYYEQNKAPYMMPFHTNWFQTKPLENGLHKFLDWALELPD 380
              .||:..| .:...::|..|:.            :..|...:.|||:|.|
Human   321 KGNQWVGYD-DQESVKSKVQYLK------------DRQLAGAMVWALDLDD 358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cda4NP_728468.1 CBM_14 33..80 CDD:279884
CE4_CDA_like_1 130..396 CDD:200596 64/311 (21%)
CHI3L1NP_001267.2 Glyco_18 23..357 CDD:214753 62/308 (20%)
GH18_chitolectin_chitotriosidase 24..380 CDD:119351 64/311 (21%)
Chitooligosaccharide binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01258 70..71
Chitooligosaccharide binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01258 97..100 1/2 (50%)
Chitooligosaccharide binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU01258 204..207 0/2 (0%)
Important for AKT1 activation and IL8 production. /evidence=ECO:0000250 324..338 3/14 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156418
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

Return to query results.
Submit another query.