DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cluap1 and Cluap1

DIOPT Version :9

Sequence 1:	NP_608470.1	Gene:	Cluap1 / 33142	FlyBaseID:	FBgn0031196	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_017172646.2	Gene:	Cluap1 / 76779	MGIID:	1924029	Length:	524	Species:	Mus musculus

Alignment Length:	538	Identity:	140/538 - (26%)
Similarity:	239/538 - (44%)	Gaps:	128/538 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DLGEHLKLLGFPRVFPLQSLANQHGSLASFHIVAELLQWLAGLIEPGATLPGGVESEEQRVLLVR 72
            |..|.::.||:||...:::...     .:|.:|:|:|.||....||...:|..:|:|:.||..::
Mouse   100 DFTEMMRALGYPRHISMENFRT-----PNFGLVSEVLLWLVKRYEPQTDIPSDIETEQDRVFFIK 159

  Fly    73 SATEFFVTKAAIRINPRKLYAAAAVTAAELQKVTRLLTSPGQN---EADNDEEDQRDQYRSLNPV 134
            :..:|..|||.|::|.:|||.|......||.|:|.:|.:..:.   |..|..|:...:::    .
Mouse   160 AIAQFMATKAHIKLNTKKLYQADGYAVKELLKITSVLYNAMKTKGMEGSNVGEEDISKFK----F 220

  Fly   135 DIGDKIEELRKARELATDLTQRGTTICEMLSKELLHKESLMSQAQRPLELLSVERTLKSAIQANQ 199
            |:|.||.:|:.||:||:::|.:|.::.::|.||:..:|.......||||:...|:.::.||:...
Mouse   221 DLGSKIADLKAARQLASEITAKGASLYDLLGKEVELRELRTEAIARPLEINETEKVMRIAIKDLL 285

  Fly   200 VRLQSSRAQL-EAAKVELNALGSKLQRRRAELERTRQRLEALHRIRPAHMAEFEDCEKELQELFQ 263
            .::|.::..| ..|..|.| |.:|:::|:.||||.|:||:.|..:|||.|.|:|..|::||:.:.
Mouse   286 AQVQKTKDLLNNVASDEAN-LEAKIEKRKLELERNRKRLQTLQSVRPAFMDEYEKVEEDLQKQYD 349

  Fly   264 RYFLRLHVRDALKSQLD----LRTKRATPISSPILQKPAENSMPFIPEGLIEDD-------DDDD 317
            .|..:......|:.||:    :..:|.         :.|||::..:...|.|::       .:||
Mouse   350 VYLEKFRNLAYLEQQLEDHHRMEQERF---------EEAENTLRLMQNKLKEEEKRLLKSGSNDD 405

  Fly   318 DEDDLDDEDEGDDGGKALSRLEMVVNGRSVFGLDSEIPDIRDEDKLMQQNNMVSAQGKRPGTATS 382
            .:.|:.::||.                      |||:     ||:.|          .:|.||..
Mouse   406 SDIDIQEDDES----------------------DSEL-----EDRRM----------SKPRTAME 433

  Fly   383 RIRPTTGRSRKAVGGRGTAGPDGGNDARAARGTRRGVATGGDADGTQLNGRNGPGSSMLNSRDED 447
            .:  ..||..|.:.| ...|.|...|.:||               ..|.|:....||   .:.||
Mouse   434 VL--MQGRPSKRIVG-AMQGGDSDEDMQAA---------------PALLGKCRTPSS---RKQED 477

  Fly   448 SSFGSSESELDVGKIMGMSGMSGMSGMSAISGISGMSNIALGAGDDDFDLNSIDDISISKLTGEL 512
                |.:||:|:                               .||:.|.:.::|.||: |:...
Mouse   478 ----SEDSEIDM-------------------------------EDDEEDDDDLEDESIA-LSPAK 506

  Fly   513 PLRPKTANKAEHHSDEDF 530
            |.|.....:....||.||
Mouse   507 PSRRIRKPEPLDESDNDF 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cluap1	NP_608470.1	Cluap1	19..285	CDD:287236	84/273 (31%)
Cluap1	XP_017172646.2	Cluap1	111..370	CDD:370905	82/262 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843300
Domainoid	1	1.000	148	1.000	Domainoid score	I4475
eggNOG	1	0.900	-	-		E1_KOG3647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14831
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4130
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56513
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006954
OrthoInspector	1	1.000	-	-		oto92288
orthoMCL	1	0.900	-	-		OOG6_104093
Panther	1	1.100	-	-	LDO	PTHR21547
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760