DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cluap1 and cluap1

DIOPT Version :9

Sequence 1:	NP_608470.1	Gene:	Cluap1 / 33142	FlyBaseID:	FBgn0031196	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_021325795.1	Gene:	cluap1 / 406281	ZFINID:	ZDB-GENE-040426-1943	Length:	448	Species:	Danio rerio

Alignment Length:	520	Identity:	133/520 - (25%)
Similarity:	236/520 - (45%)	Gaps:	97/520 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFKDVRDLGEHLKLLGFPRVFPLQSLANQHGSLASFHIVAELLQWLAGLIEPGATLPGGVESEE 65
            |||:|:|:..|.::.||:||:..:::..:     .:|.:|||:|.||....||...:|..|::|.
Zfish     1 MSFRDLRNFTEMMRALGYPRLISMENFRS-----PNFPLVAEILIWLVKRYEPQMEIPSDVDTES 60

  Fly    66 QRVLLVRSATEFFVTKAAIRINPRKLYAAAAVTAAELQKVTRLLTSPGQNEADNDEEDQRDQYRS 130
            .||..:::..:|..|||.:::|.::||.|......|:.|:|.:|.: .....:|...||.:...|
Zfish    61 DRVFFIKAVAQFMATKAHVKLNLKRLYQADGYAVKEMLKITSILYN-AMKTKENAGGDQNNDENS 124

  Fly   131 LNPVDIGDKIEELRKARELATDLTQRGTTICEMLSKELLHKESLMSQAQRPLELLSVERTLKSAI 195
            ....|:|.||.:|:.||:|.:::|.:|..:.::|.:|...:||..:...||||:...||.:::|:
Zfish   125 KFKFDLGSKIADLKLARQLGSEITAKGAALFDLLGQEEDLRESRTAAIARPLEITETERAIRAAV 189

  Fly   196 QANQVRLQSSRAQLEAAKVELNALGSKLQRRRAELERTRQRLEALHRIRPAHMAEFEDCEKELQE 260
            :.....:|.::..|.....:..:|.:|:::::.:|||.::||:.|..:|||.|.|:|..|::|::
Zfish   190 KDVTESIQMTKDLLNNVSSDEASLEAKIEKKKQDLERNQKRLQTLQSVRPAFMDEYEKIEEDLEK 254

  Fly   261 LFQRYFLRLHVRDALKSQLD--LRTKRATPISSPILQKPAENSMP-----FIPEGLIEDDDDDDD 318
            .:|.|..:......|:.|||  .|.::.....:.:..|..:|.:.     .:..|:..|:|.|.|
Zfish   255 QYQTYVEKYRNLSFLEQQLDDYHRVEQERFEEAEMAMKMRQNKLKEEEKRLMRSGVARDEDSDVD 319

  Fly   319 --EDDLDDEDEGDDGGKALSR--LEMVVNGR-------SVFGLDSEIPDIRDEDKLMQQNNMVSA 372
              ||:..|.|. |||.:|...  ....::||       |:.|.|||.|.:::
Zfish   320 IPEDEGSDSDI-DDGQQARPHHPRHTQISGRGGARFIGSMRGGDSEEPKVKE------------- 370

  Fly   373 QGKRPGTATSRIRPTTGRSRKAVGGRGTAGPDGGNDARAARGTRRGVATGGDADGTQLNGRNGPG 437
               |.|.:.|      ||.:|                      ::.|....:.|
Zfish   371 ---RAGLSGS------GRKQK----------------------KKKVTEDSEID----------- 393

  Fly   438 SSMLNSRDEDSSFGSSESE-------LDVGKIMGMSGMSGMSGMSAISGISGMSNIALGAGDDDF 495
               ::..|||......|.|       .|...:.|.||..|.:..|....|       |...|:||
Zfish   394 ---VDDDDEDDDEDGEEDEEENEDLDEDNDSLEGSSGKPGRTNQSLHPQI-------LEESDNDF 448

Fly 496 495
Zfish 449 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cluap1	NP_608470.1	Cluap1	19..285	CDD:287236	78/267 (29%)
cluap1	XP_021325795.1	Cluap1	19..279	CDD:313461	77/265 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588394
Domainoid	1	1.000	150	1.000	Domainoid score	I4360
eggNOG	1	0.900	-	-		E1_KOG3647
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14831
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4094
OMA	1	1.010	-	-		QHG56513
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006954
OrthoInspector	1	1.000	-	-		oto39981
orthoMCL	1	0.900	-	-		OOG6_104093
Panther	1	1.100	-	-	LDO	PTHR21547
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4021
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790