Protein Alignment CG17598 and PPM1H

DIOPT Version :10

• Sequence 1: NP_608468.1
• Gene: CG17598 / 33140
• FlyBaseID: FBgn0031194
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_065751.1
• Gene: PPM1H / 57460
• HGNCID: 18583
• Length: 514
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 206/557 - (36%)
• Similarity: 298/557 - (53%)
• Gaps: 111/557 - (19%)

  Fly     8 RIISAIAPDLPPLPGNSERAIGSG-SGHHHSSTHQRLRFGASGGQPMPDKFPYARPPFLQLLTPD 71
            |:.||:|        |....|.:| ||..|..       |:.||..:|.:|||.||.||. |:.|
Human     4 RVKSAVA--------NFMGGIMAGSSGSEHGG-------GSCGGSDLPLRFPYGRPEFLG-LSQD 52

  Fly    72 ELRASADHNVRPIIVPRDINLLPWGTGYAECVNSGKSEWNEDQGAFCR---------QVLSDPEH 127
            |:..||||..|||::.::...|||.|||||.:|:|||..|||| |.|.         .|.|.|..
Human    53 EVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQ-ASCEVLTVKKKAGAVTSTPNR 116

  Fly   128 ----KHPDLP-----------------YTYFGIFDGHAGYGAALAASHQFHHILHEKLVDCLELL 171
                :...||                 ..|:.:||||||.|||:.||....|.:.|:|.|.:::|
Human   117 NSSKRRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDIL 181

  Fly   172 L-------------PRDADATN---------GGGEGNKLNPTFPHPIYF-QRRVTKDELIIGALE 213
            .             |.:..|.:         .||.|...:|:.|...:| ::::..:.|:|||||
Human   182 KNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALE 246

  Fly   214 SAFFNMDSLIAQDCDRYRDAGGCTACVSLFIDGKMYVANAGDSRAVLCQRRATPERPQTNTDSGI 278
            |||..||..|.::...|..:|||||.:.:.:.||:||||||||||::.:....
Human   247 SAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEI------------ 299

  Fly   279 EPDPLEASCYPVPFSADHTPETERERLLNVARLKPHLMGKHYVAMEYAKRPHIKDMGQRILCRQG 343
                       :|.|::.||||||:||..:|.::|||:|..:..:|:.:|...|::|:::|.|..
Human   300 -----------IPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDF 353

  Fly   344 TMRGWTYKTLTMEDLCMPVVNGEGKRSRLLGTLGVTRGFGDHELLAINTGIQIKPFLTPHPDVRQ 408
            .|.||.|||:..|||..|::.||||::|::.|:|||||.|||:|...::.|.|||||:..|:||.
Human   354 NMTGWAYKTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRI 418

  Fly   409 RDLTQVVSIPDEDNRDGDYG---VLVMATDGLWDVSENDAVSRTVFQTLSKYS-TEKHRYTMVAQ 469
            .||::.           |:|   ||::||||||||..|:.|:..:.|.|.... .:.||||:.||
Human   419 YDLSKY-----------DHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQ 472

  Fly   470 ELVARARGKINDSGHWRLADSKAAATVDDISVIVIPV 506
            :||.||||.:.|.| ||:::.:..:. |||||.|||:
Human   473 DLVMRARGVLKDRG-WRISNDRLGSG-DDISVYVIPL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17598	NP_608468.1	PP2Cc	98..506	CDD:238083	170/464 (37%)
PPM1H	NP_065751.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..135		5/25 (20%)
		PP2Cc	143..507	CDD:238083	151/399 (38%)