DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17598 and Ppm1h

DIOPT Version :9

Sequence 1:	NP_001259780.1	Gene:	CG17598 / 33140	FlyBaseID:	FBgn0031194	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001103688.1	Gene:	Ppm1h / 319468	MGIID:	2442087	Length:	513	Species:	Mus musculus

Alignment Length:	552	Identity:	202/552 - (36%)
Similarity:	297/552 - (53%)	Gaps:	102/552 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RIISAIAPDLPPLPGNSERAIGSGSGHHHSSTHQRLRFGASGGQPMPDKFPYARPPFLQLLTPDE 72
            |:.||:|..:..:...|     |||.|..|         ..||..:|.:|||.||.||. |:.||
Mouse     4 RVKSAVANFMGGIMAGS-----SGSEHGGS---------GCGGSDLPLRFPYGRPEFLG-LSQDE 53

  Fly    73 LRASADHNVRPIIVPRDINLLPWGTGYAECVNSGKSEWNEDQGAFCR---------QVLSDPEH- 127
            :..||||..|||::.::...|||.|||||.:|:|||..|||| |.|.         .:.|.|..
Mouse    54 VECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQ-ASCEVLTVKKKAGTITSTPNRN 117

  Fly   128 --KHPDLP-----------------YTYFGIFDGHAGYGAALAASHQFHHILHEKLVDCLELL-- 171
              :...||                 ..|:.:||||||.|||:.||....|.:.::|.|.:|:|
Mouse   118 SKRRSSLPNGEGLQLKENSESEGISCHYWSLFDGHAGSGAAVVASRLLQHHITQQLQDIVEILKN 182

  Fly   172 --------LPRDADATNG------------GGEGNKLNPTFPHPIYF-QRRVTKDELIIGALESA 215
                    |..:.::|..            ||.|...:|:.|...:| ::::..:.|:|||||||
Mouse   183 SAILPPTCLGEEPESTPAHGRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESA 247

  Fly   216 FFNMDSLIAQDCDRYRDAGGCTACVSLFIDGKMYVANAGDSRAVLCQRRATPERPQTNTDSGIEP 280
            |..||..|.::...|..:|||||.:.:.:.||:||||||||||::.:....
Mouse   248 FKEMDLQIERERSAYNISGGCTALIVVCLLGKLYVANAGDSRAIIIRNGEI-------------- 298

  Fly   281 DPLEASCYPVPFSADHTPETERERLLNVARLKPHLMGKHYVAMEYAKRPHIKDMGQRILCRQGTM 345
                     :|.|::.||||||:||..:|.::|||:|..:..:|:.:|...|::|:::|.|...|
Mouse   299 ---------IPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNM 354

  Fly   346 RGWTYKTLTMEDLCMPVVNGEGKRSRLLGTLGVTRGFGDHELLAINTGIQIKPFLTPHPDVRQRD 410
            .||.|||:..:||..|::.||||::|::.|:|||||.|||:|...::.|.|||||:..|:||..|
Mouse   355 TGWAYKTIEDDDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRVYD 419

  Fly   411 LTQVVSIPDEDNRDGDYGVLVMATDGLWDVSENDAVSRTVFQTLSKYS-TEKHRYTMVAQELVAR 474
            |::.....|:        ||::||||||||..|:.|:..:.|.|.... .:.||||:.||:||.|
Mouse   420 LSRYEHGADD--------VLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMR 476

  Fly   475 ARGKINDSGHWRLADSKAAATVDDISVIVIPV 506
            |||.:.|.| ||:::.:..:. |||||.|||:
Mouse   477 ARGVLKDRG-WRISNDRLGSG-DDISVYVIPL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17598	NP_001259780.1	PP2Cc	98..506	CDD:238083	167/460 (36%)
Ppm1h	NP_001103688.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..133		4/23 (17%)
Ppm1h	NP_001103688.1	PP2Cc	142..506	CDD:238083	149/396 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7228
eggNOG	1	0.900	-	-		E1_KOG1323
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2532
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48683
OrthoDB	1	1.010	-	-		D272116at33208
OrthoFinder	1	1.000	-	-		FOG0004127
OrthoInspector	1	1.000	-	-		otm43486
orthoMCL	1	0.900	-	-		OOG6_107406
Panther	1	1.100	-	-	LDO	PTHR13832
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2968
SonicParanoid	1	1.000	-	-		X2870
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870