Protein Alignment S6kII and RPS6KA5

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_004746.2
• Gene: RPS6KA5 / 9252
• HGNCID: 10434
• Length: 802
• Species: Homo sapiens
• Alignment Length: 792
• Identity: 323/792 - (40%)
• Similarity: 447/792 - (56%)
• Gaps: 91/792 - (11%)

  Fly   152 ETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIKEGH-DKADPSQFELLRVLGEGSFGKVFL 215
            |.||...||.|.||...:..|.|...::  ||:.....|| :|.....||||:|||.|::|||||
Human     3 EEGGSSGGAAGTSADGGDGGEQLLTVKH--ELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFL 65

  Fly   216 VRKIIGKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHA-FIVRLHYAFQTPGKLYLI 277
            ||||.|.|.|.|||||||||||:  |.|....:..||::|..:..: |:|.|||||||..||:||
Human    66 VRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLI 130

  Fly   278 LDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTD 342
            ||::.||:|||.||:...|||.:|:.|:.|:.||:.|||.|||||||:|.||||||.:||:.|||
Human   131 LDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTD 195

  Fly   343 FGLSKQPL--DGSKTYSFCGTVEYMAPEIV--NRKGHDFAADWWSFGVLMYEMLTGNLPF----H 399
            |||||:.:  :..:.||||||:|||||:||  ...|||.|.||||.||||||:|||..||    .
Human   196 FGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGE 260

  Fly   400 GQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVR 464
            ..::.|...:||:|:...|:.:|..|:.|::.|..::|:.|||.|.:...:||.|.||..|:|..
Human   261 KNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDD 325

  Fly   465 LERKQVRPPFIPAVSRD--DAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCA 527
            |..|:|..||.|.: ||  |...|..|:|...|..||.. :..|:.::|:|:|||||.:|..:
Human   326 LAAKKVPAPFKPVI-RDELDVSNFAEEFTEMDPTYSPAA-LPQSSEKLFQGYSFVAPSILFKR-- 386

  Fly   528 GSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVL---------PGNFHAEYNL-LQE--LGRGTFS 580
              |.........|         :|..|  |||.         ...|:..|:| |::  ||.|:||
Human   387 --NAAVIDPLQFH---------MGVER--PGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFS 438

  Fly   581 VCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAY 645
            :||.|.|:.|.:.:|||:|.|        ...|:..:|:..:.....|||||.|:.|:.|....:
Human   439 ICRKCVHKKSNQAFAVKIISK--------RMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTF 495

  Fly   646 LVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPE 710
            ||||||.||||.:||.......|:|||.::|.:.|||:::|:.|||||||||.|:::.......|
Human   496 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLE 560

  Fly   711 TLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFAS 775
             :|:.|.|||:....||..|.|||:|.::.|||:|.:.|||.:||:|||||:||.||||:.||.|
Human   561 -IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQS 624

  Fly   776 TPND----SPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLRE 836
            ....    |...|:|:|..|...|....|..:|..||:|::.:|.:.|..|...:.:..::||::
Human   625 HDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 689

  Fly   837 QFAGGVQLTEYAVAPGSQLS---------LGAQQQQQNHISMALRGAVDATFRAIAIPQAAN--V 890
                           |||||         ||:.       ..|:...|.|||.|....:...  :
Human   690 ---------------GSQLSSNPLMTPDILGSS-------GAAVHTCVKATFHAFNKYKREGFCL 732

  Fly   891 GPVELSMLAKRR 902
            ..|:.:.|||||
Human   733 QNVDKAPLAKRR 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	161/326 (49%)
		STKc_RSK_C	567..883	CDD:270993	124/331 (37%)
RPS6KA5	NP_004746.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		8/19 (42%)
		STKc_MSK1_N	48..337	CDD:270764	151/288 (52%)
		S_TK_X	320..379	CDD:214529	22/60 (37%)
		STKc_MSK1_C	418..727	CDD:271081	125/339 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..802		4/4 (100%)