DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and RPS6KA4

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_003933.1	Gene:	RPS6KA4 / 8986	HGNCID:	10433	Length:	772	Species:	Homo sapiens

Alignment Length:	753	Identity:	314/753 - (41%)
Similarity:	424/753 - (56%)	Gaps:	64/753 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 EFELKEVIKEGH-DKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVK 241
            |..:.|....|| :|.....||||:|||.|::||||||||..|.|||.|||||||:||.|  :.|
Human    13 ELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAK 77

  Fly   242 DRVRSTNERKILADVGHA-FIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 305
            .:..:..||.:|..|..| |:|.|||||||..||:||||::.||::||.|.:...|.|.:|:.|.
Human    78 TQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYG 142

  Fly   306 AELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL--DGSKTYSFCGTVEYMAPE 368
            .|:.||:.|||.|||||||||.||:|||..|||.||||||||:.|  :..:|:|||||:||||||
Human   143 GEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207

  Fly   369 IVNRK-GHDFAADWWSFGVLMYEMLTGNLPF--HGQ--TRQETMNQILRSKLGMPENLSPEAQSL 428
            |:..| ||..|.||||.|:|::|:|||..||  .|:  |:.|...:||:.....|..:.|.||.|
Human   208 IIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDL 272

  Fly   429 LRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTS 492
            |:.|..::|:.|||||.||..:::.|.||..:|||.|..:::..||.|.: |..|...|..|:|.
Human   273 LQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTR 337

  Fly   493 KSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLP 557
            ..|..||.|........||:|:|||||.:|...   :|...|...........|.....|...:.
Human   338 LEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDH---NNAVMTDGLEAPGAGDRPGRAAVARSAMM 399

  Fly   558 GVLPGNFHAEYNL-LQE--LGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEV 619
            ...|  |..:|.| |:|  ||:|:|||||.|..|.|.:.:|||::        |....|:...||
Human   400 QDSP--FFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKIL--------SRRLEANTQREV 454

  Fly   620 EIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAY 684
            ..:....:|||:|.|:.|:.|....|||:|||:|||||:.|.......|||||.:||::.|||::
Human   455 AALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSF 519

  Fly   685 LHEH-GVVHRDLKPSNMIYASMRQTP-ETLKLCDLGFAKQLRADNGL-LMTPCYTANFVAPEVLK 746
            :||. |||||||||.|::||.  .|| ..:|:.|.|||:......|: :.|||:|..:.|||:|.
Human   520 MHEEAGVVHRDLKPENILYAD--DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLA 582

  Fly   747 RQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPD----VILKRIGSGQIDFTSSRWALISVPA 807
            :||||.:||:|||||:||:||||:.||.........    .|:.:|..|:.......|..:|..|
Human   583 QQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEA 647

  Fly   808 KELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALR 872
            |||:|.:|.:.|..|.....:....||::   |..:.:.....|....|.|.          |:|
Human   648 KELVRGLLTVDPAKRLKLEGLRGSSWLQD---GSARSSPPLRTPDVLESSGP----------AVR 699

  Fly   873 GAVDATFRAIAIPQAANVG--------PVELSMLAKRR 902
            ..::|||.|.      |.|        .||.:.|||||
Human   700 SGLNATFMAF------NRGKREGFFLKSVENAPLAKRR 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	142/267 (53%)
		STKc_RSK_N	203..517	CDD:270734	160/324 (49%)
		STKc_RSK_C	567..883	CDD:270993	125/325 (38%)
		S_TKc	568..834	CDD:214567	113/275 (41%)
RPS6KA4	NP_003933.1	STKc_MSK2_N	32..364	CDD:270765	166/331 (50%)
		S_TKc	33..301	CDD:214567	142/267 (53%)
		PKc_like	404..714	CDD:304357	128/338 (38%)
		S_TKc	417..674	CDD:214567	109/266 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..696		5/25 (20%)
		Required for nuclear targeting and association with MAPK14	725..772		5/7 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..772		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850