Protein Alignment S6kII and SCH9

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_012075.1
• Gene: SCH9 / 856612
• SGDID: S000001248
• Length: 824
• Species: Saccharomyces cerevisiae
• Alignment Length: 595
• Identity: 190/595 - (31%)
• Similarity: 289/595 - (48%)
• Gaps: 111/595 - (18%)

  Fly    23 VSSTSSSNNAEQQCSSSGLGLQL---RQRMQITSSGCSSLAVTPMEHTP--------TEDDESGG 76
            :|||||.:..:::.:::..|...   |.::::|......|.....:..|        :|...:|.
Yeast   156 LSSTSSLSINQREAAAAAYGPDTDIPRGKLEVTIIEARDLVTRSKDSQPYVVCTFESSEFISNGP 220

  Fly    77 GNSGVTSSVTTVTSSQRRQQLQQV--QQQSALQAALEQHHISPT----ADLDS----ARKRP--T 129
            .:.|..::.....::.:..|.|.:  ..::....|..|||.:.:    :.|.|    .:|:|  |
Yeast   221 ESLGAINNNNNNNNNNQHNQNQHINNNNENTNPDAASQHHNNNSGWNGSQLPSIKEHLKKKPLYT 285

  Fly   130 HRTLCPPPEL---MELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELK------- 184
            ||:.....:|   ..::|...:....:.|...|      |..:.:.|::..:..|::.
Yeast   286 HRSSSQLDQLNSCSSVTDPSKRSSNSSSGSSNG------PKNDSSHPIWHHKTTFDVLGSHSELD 344

  Fly   185 -EVIKEGHDKA----------------------------------------------------DP 196
             .|....||..                                                    .|
Yeast   345 ISVYDAAHDHMFLGQVRLYPMIHNLAHASQHQWHSLKPRVIDEVVSGDILIKWTYKQTKKRHYGP 409

  Fly   197 SQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRST-NERKIL---ADVG 257
            ..||:||:||:|:||:|:.|:|   ||...:||||||.|..:..|:.:..| .||.||   |...
Yeast   410 QDFEVLRLLGKGTFGQVYQVKK---KDTQRIYAMKVLSKKVIVKKNEIAHTIGERNILVTTASKS 471

  Fly   258 HAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIY 322
            ..|||.|.::||||..|||:.|::.||:||..|.||..|:|:..|||:|||.||:.|||...|:|
Yeast   472 SPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFSEDRAKFYIAELVLALEHLHDNDIVY 536

  Fly   323 RDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPE-IVNRKGHDFAADWWSFGV 386
            |||||||||||.:|:|||.||||||..|. .:|.:||||.||:||| :::..|:....|:||.||
Yeast   537 RDLKPENILLDANGNIALCDFGLSKADLK-DRTNTFCGTTEYLAPELLLDETGYTKMVDFWSLGV 600

  Fly   387 LMYEMLTGNLPFHGQTRQETMNQILRSKLGMPEN-LSPEAQSLLRALFKRNPQNRLGAGAQGILD 450
            |::||..|..||..:..|:...:|...|:..|.: ||.|.:|.::.|..|||::||||...| .:
Yeast   601 LIFEMCCGWSPFFAENNQKMYQKIAFGKVKFPRDVLSQEGRSFVKGLLNRNPKHRLGAIDDG-RE 664

  Fly   451 IKAHCFFATIDWVRLERKQVRPPFIP-AVSRDDAFYFDVEYTSKSP----RDSP---GGPISASA 507
            ::||.|||.|||..|::|::.|||.| .||..|...||.|:|:.|.    :..|   ..|:|.:.
Yeast   665 LRAHPFFADIDWEALKQKKIPPPFKPHLVSETDTSNFDPEFTTASTSYMNKHQPMMTATPLSPAM 729

  Fly   508 HEIFRGFSFV 517
            ...|.||:||
Yeast   730 QAKFAGFTFV 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	148/327 (45%)
		STKc_RSK_C	567..883	CDD:270993
SCH9	NP_012075.1	YPK1_N_like	181..407	CDD:212165	30/231 (13%)
		STKc_Sck1_like	418..738	CDD:270738	147/324 (45%)