DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and FPK1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_014445.1	Gene:	FPK1 / 855783	SGDID:	S000005330	Length:	893	Species:	Saccharomyces cerevisiae

Alignment Length:	595	Identity:	176/595 - (29%)
Similarity:	260/595 - (43%)	Gaps:	109/595 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ADSQKDLRQ--QPQQQQQQQHVSS--TSSSNNAEQQCSSSGLGL-QLRQRMQITSSGCSSLAVTP 63
            |.|..||.:  ||.......|..|  ||.:|:.....:.|.|.| ::::..::............
Yeast   261 AMSSHDLDEGFQPYANGSGIHFLSTPTSKTNSLTNTKNLSNLSLNEIKENEEVQEFNNEDFFFHD 325

  Fly    64 MEHTPTEDDESGGGNSGVTSSVTTVT----------------SSQRRQQLQQVQQQSALQAALEQ 112
            :....:..|...|..|..:|...|:|                .:...:..::.:||:....  :.
Yeast   326 IPKDLSLKDTLNGSPSRGSSKSPTITQTFPSIIVGFDNEYEEDNNNDKHDEKEEQQTTTDN--KT 388

  Fly   113 HHISPTADLDSAR----KRPTHRTLCPPP--ELMELSDSESQGGVETGGR---REGATGRS---- 164
            .::|||.....|.    |.|..|....|.  :|...:...|....:|.|.   .:...|:|
Yeast   389 RNLSPTKQNGKATHPRIKIPLRRAASEPNGLQLASATSPTSSSARKTSGSSNINDKIPGQSVPPP 453

  Fly   165 --------APDLED-TEPLYETENEFELKEVIKEGHD-KADPSQFELLRVLGEGSFGKVFLVRKI 219
                    :|.:.| .||  ........|....:..| ...|..||.:|:||:|..|||||||:
Yeast   454 NSFFPQEPSPKISDFPEP--RRSRRLRTKSFSNKFQDIMVGPQSFEKIRLLGQGDVGKVFLVRE- 515

  Fly   220 IGKDAGTLYAMKVLKKATLKVKDRV-RSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRG 283
              |....:||:|||.|..:..:::: |...|::|||...|.|||.|:::||:...|||.:::..|
Yeast   516 --KKTNRVYALKVLSKDEMIKRNKIKRVLTEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCMG 578

  Fly   284 GDLFTRLS--KEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGL- 345
            |:.|..|.  |.....|:|.:||.:|:..|:.:||.||.||||||||||||.:.|||.|:||.|
Yeast   579 GEFFRALQTRKTKCICEDDARFYASEVTAALEYLHLLGFIYRDLKPENILLHQSGHIMLSDFDLS 643

  Fly   346 -----SKQPL----------------DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMY 389
                 ||.|:                ||.:|.||.||.||:|||::...||..|.|||:.|:|:|
Yeast   644 IQAKDSKVPVVKGSAQSTLVDTKICSDGFRTNSFVGTEEYIAPEVIRGNGHTAAVDWWTLGILIY 708

  Fly   390 EMLTGNLPFHGQTRQETMNQILRSKLGMPEN--LSPEAQSLLRALFKRNPQNRLGAGAQGILDIK 452
            |||.|..||.|....||...||::::..|.|  :|...:.|::.|..:|...|||. ..|..|:|
Yeast   709 EMLFGFTPFKGDNTNETFTNILKNEVSFPNNNEISRTCKDLIKKLLTKNESKRLGC-KMGAADVK 772

  Fly   453 AHCFFATIDWVRLERKQVRPPFIPAVSRD----------------------------DAFYFDVE 489
            .|.||..:.|..|..::  ||.||.:|.|                            :.|...||
Yeast   773 KHPFFKKVQWSLLRNQE--PPLIPVLSEDGYDFAKLSSNKKRQTSQDSHKHLDEQEKNMFEERVE 835

  Fly   490 YTSKSPRDSP 499
            |..:...|.|
Yeast   836 YDDEVSEDDP 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	117/284 (41%)
		STKc_RSK_N	203..517	CDD:270734	131/352 (37%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
FPK1	NP_014445.1	STKc_phototropin_like	494..797	CDD:270726	125/308 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840