DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and CTK1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_012783.1	Gene:	CTK1 / 853718	SGDID:	S000001622	Length:	528	Species:	Saccharomyces cerevisiae

Alignment Length:	331	Identity:	78/331 - (23%)
Similarity:	130/331 - (39%)	Gaps:	74/331 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 LRVL--GEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRL 264
            ||::  |||::|||:   |....:...|.|:|.|:....:....:.|..|.|:|....|..:..:
Yeast   184 LRIMQVGEGTYGKVY---KAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTI 245

  Fly   265 -HYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPE 328
             ....::...:|:|.::.........|:|||..:....|....:|.|.|.:||...|::||:|..
Yeast   246 KEIMVESQKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGS 310

  Fly   329 NILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPE-IVNRKGHDFAADWWSFGVLMYEML 392
            |||:|..|::.:|||||:::....:...:...|:.|..|| ::....:....|.|..|.|:.|:.
Yeast   311 NILIDNQGNLKITDFGLARKMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELF 375

  Fly   393 TGNLPFHGQTRQETMNQILRSKLGMP--------------------------ENLSPEAQSLL-- 429
            .....|.|....|.:..|.:. :|.|                          .|.|.:.:|:|
Yeast   376 NKTAIFQGSNELEQIESIFKI-MGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPS 439

  Fly   430 ----------------------RAL----FKRNPQNRLGAGAQGILD--IKAHCFFATIDWVRLE 466
                                  .||    ||..|:..     ..:||  :..|.:     .|:|.
Yeast   440 SKCLQLAINLLCYDQTKRFSATEALQSDYFKEEPKPE-----PLVLDGLVSCHEY-----EVKLA 494

  Fly   467 RKQVRP 472
            |||.||
Yeast   495 RKQKRP 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	71/314 (23%)
		STKc_RSK_N	203..517	CDD:270734	77/330 (23%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
CTK1	NP_012783.1	STKc_CDK9_like	183..469	CDD:270832	65/288 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000