DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and PK1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001326081.1	Gene:	PK1 / 820020	AraportID:	AT3G08730	Length:	465	Species:	Arabidopsis thaliana

Alignment Length:	463	Identity:	173/463 - (37%)
Similarity:	256/463 - (55%)	Gaps:	46/463 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 SQRRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTHRTLCPPPELMELSDSESQGGVETGG 155
            |.:|....::|:|..|..:.....:....:|:.:      ....|.||  |.:|...........
plant     3 SSQRPVPNKIQKQQYLSISPSNSVLKDDVELEFS------DVFGPLPE--EANDIAYDEPAVVYS 59

  Fly   156 RREGATGRSAPDLEDTE----PLYETENEFELKEVIK----------EGHDKADPSQ-------- 198
            |.....|..:.|....:    .|.|||:..:|.|.::          .|:|.:|..:
plant    60 RSHSLVGPCSLDSHSLKLTKLTLLETEDSIDLVECLEGESLKENDDFSGNDDSDNEKALEGDLVK 124

  Fly   199 ---------FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTN-ERKIL 253
                     ||:::|:|:|:||||:.|||   |:...:|||||::|..:..|:...... ||.||
plant   125 VSGVVGIDDFEVMKVVGKGAFGKVYQVRK---KETSEIYAMKVMRKDHIMEKNHAEYMKAERDIL 186

  Fly   254 ADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTL 318
            ..:.|.|||:|.|:|||..:|||:|||:.||.||.:|..:.:|.|:..:.|.||:..|::|||..
plant   187 TKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEK 251

  Fly   319 GIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWS 383
            ||::|||||||||:|..||:.||||||:|:..:.:::.|.|||.||||||||..||||.||||||
plant   252 GIMHRDLKPENILMDTDGHVMLTDFGLAKEFEENTRSNSMCGTTEYMAPEIVRGKGHDKAADWWS 316

  Fly   384 FGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGI 448
            .|:|:||||||..||.| ::.:...:|::.|:.:|:.||.||.::|:.|.::.|:.|||:|..|.
plant   317 VGILLYEMLTGKPPFLG-SKGKIQQKIVKDKIKLPQFLSNEAHAILKGLLQKEPERRLGSGLSGA 380

  Fly   449 LDIKAHCFFATIDWVRLERKQVRPPFIPAVS-RDDAFYFDVEYTSKSPRDSP-GGPISASAHEIF 511
            .:||.|.:|..|:|.:||.::|.|.|.|.|| |.....||..:|..|..||| ..|.|......|
plant   381 EEIKQHKWFKGINWKKLEAREVMPSFKPEVSGRQCIANFDKCWTDMSVLDSPASSPSSDPKANPF 445

  Fly   512 RGFSFVAP 519
            ..|::|.|
plant   446 TNFTYVRP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	125/258 (48%)
		STKc_RSK_N	203..517	CDD:270734	146/316 (46%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
PK1	NP_001326081.1	STKc_AGC	140..389	CDD:270693	122/252 (48%)
PK1	NP_001326081.1	S_TK_X	390..452	CDD:214529	22/61 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	259	1.000	Domainoid score	I491
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1096
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880