DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and Rps6ka1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_006239145.1	Gene:	Rps6ka1 / 81771	RGDID:	620675	Length:	741	Species:	Rattus norvegicus

Alignment Length:	751	Identity:	436/751 - (58%)
Similarity:	535/751 - (71%)	Gaps:	62/751 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 SAPDLEDTEPLYETENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLY 228
            |.|..:..|.:.:   |..:...:|.|.:|||||.||||:|||:|||||||||||:...|.|.||
  Rat    36 SGPQQDSDEGILK---EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDNGHLY 97

  Fly   229 AMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKE 293
            ||||||||||||:||||:..||.|||||.|.|:|:|||||||.||||||||||||||||||||||
  Rat    98 AMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 162

  Fly   294 VMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYS 357
            |||||||||||||||||.::|||:|||||||||||||||||.|||.||||||||:.:| ..|.||
  Rat   163 VMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 227

  Fly   358 FCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLS 422
            |||||||||||:|||:||..:|||||:||||:|||||:|||.|:.|:|||..||::|||||:.||
  Rat   228 FCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLS 292

  Fly   423 PEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYF 486
            .||||||||||||||.||||:|..|..:||.|.|::||||.:|.|::::|||.|||:: ||.|||
  Rat   293 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF 357

  Fly   487 DVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVG 551
            |.|:||::||||||.|.||.||::||||||||..|:|..   |...:|.| ||||:..
  Rat   358 DTEFTSRTPRDSPGIPPSAGAHQLFRGFSFVATGLMEDD---SKPRATQA-PLHSVVQ------- 411

  Fly   552 APRTLPGVLPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSA 613
                   .|.|.   |...|.:.:.:|.|::|||:.|.|:|:...||||||:|         :..
  Rat   412 -------QLHGKNLVFSDGYIVKETIGVGSYSVCKRCVHKATNMEYAVKVIDK---------SKR 460

  Fly   614 DCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTI 678
            |..||:||:||||.||||:||..||:|:...|||.||::||||||:||......|.|||.||.||
  Rat   461 DPSEEIEILLRYGQHPNIITLKDVYDDSKHVYLVTELMRGGELLDKILRQKFFSEREASFVLYTI 525

  Fly   679 ASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPE 743
            :..|.|||..|||||||||||::|......||.|::||.||||||||:|||||||||||||||||
  Rat   526 SKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPE 590

  Fly   744 VLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAK 808
            ||||||||..|||||||||||.||:|.||||:.|:|:|:.||.||.||:.......|..:|..||
  Rat   591 VLKRQGYDEGCDIWSLGVLLYTMLAGYTPFANGPSDTPEEILTRISSGKFTLNGGNWNTVSETAK 655

  Fly   809 ELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMAL-R 872
            :|:.:|||:.|..|.||.::|:|.|          :|:....|.||||         |..:.| :
  Rat   656 DLVSKMLHVDPHQRLTAKQVLQHPW----------ITQKDKLPQSQLS---------HQDLQLVK 701

  Fly   873 GAVDATFRAIA----IPQAANVGPVELSMLAKRRAK 904
            ||:.||:.|::    .||   :.|:|.|:||:||.:
  Rat   702 GAMAATYSALSSSKPTPQ---LKPIESSILAQRRVR 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	199/258 (77%)
		STKc_RSK_N	203..517	CDD:270734	233/315 (74%)
		STKc_RSK_C	567..883	CDD:270993	164/316 (52%)
		S_TKc	568..834	CDD:214567	150/265 (57%)
Rps6ka1	XP_006239145.1	S_TKc	68..326	CDD:214567	199/257 (77%)
		STKc_RSK_N	72..388	CDD:270734	233/315 (74%)
		STKc_RSK1_C	422..712	CDD:271077	164/317 (52%)
		Pkinase	424..681	CDD:278497	151/275 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I726
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	827	1.000	Inparanoid score	I435
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm45903
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880