DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and rps6ka1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001071243.1	Gene:	rps6ka1 / 777728	ZFINID:	ZDB-GENE-060929-516	Length:	310	Species:	Danio rerio

Alignment Length:	329	Identity:	175/329 - (53%)
Similarity:	218/329 - (66%)	Gaps:	28/329 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   577 GTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDA 641
            |:||||:.|.|:.:...||||||:|         ||.|..||:||:||||.||||:||..||::.
Zfish     2 GSFSVCKRCIHKVTNTEYAVKVIDK---------TSTDPTEEIEILLRYGQHPNIITLKDVYDNG 57

  Fly   642 GSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMR 706
            ...|||.||::|||||||||......|.||||||.||...|.|||..|||||||||||::|....
Zfish    58 KQVYLVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLKPSNILYVDES 122

  Fly   707 QTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRT 771
            ..||:|::||.||||||||||||||||||||||||||||||||||..|||||||||||.|::|.|
Zfish   123 GNPESLRICDFGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMIAGFT 187

  Fly   772 PFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLRE 836
            |||:.|.|:|:.||.|||||:...|...|..:|..||:|:.:|||:.|..|.||.::|:|.|:
Zfish   188 PFANGPEDTPEEILSRIGSGRFTLTGGNWDAVSDAAKDLVSKMLHVDPHQRLTARQVLKHPWI-- 250

  Fly   837 QFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAIPQ-AANVGPVELSMLAK 900
                 ||..:   .|.|||        |:..:..::||:.||:.|:...| ...:.|:|.|.||:
Zfish   251 -----VQRDK---LPNSQL--------QHQDAKLVKGAMAATYSALKSSQPPPELKPIESSFLAQ 299

  Fly   901 RRAK 904
            ||.|
Zfish   300 RRVK 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567
		STKc_RSK_N	203..517	CDD:270734
		STKc_RSK_C	567..883	CDD:270993	166/305 (54%)
		S_TKc	568..834	CDD:214567	153/256 (60%)
rps6ka1	NP_001071243.1	PKc_like	1..281	CDD:304357	166/305 (54%)
rps6ka1	NP_001071243.1	S_TKc	2..250	CDD:214567	153/256 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I709
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	828	1.000	Inparanoid score	I444
OMA	1	1.010	-	-		QHG55819
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm24234
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.870