DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and Rps6ka5

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_705815.1	Gene:	Rps6ka5 / 73086	MGIID:	1920336	Length:	863	Species:	Mus musculus

Alignment Length:	869	Identity:	326/869 - (37%)
Similarity:	450/869 - (51%)	Gaps:	162/869 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 ESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIKEGH-DKADPSQFELLRVLGEGS 209
            |.:||...|....|.:|      :..|.|...::  ||:.....|| :|.....||||:|||.|:
Mouse     2 EGEGGGSGGAGTSGDSG------DGGEQLLTVKH--ELRTANLTGHAEKVGIENFELLKVLGTGA 58

  Fly   210 FGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHA-FIVRLHYAFQTP 271
            :|||||||||.|.|||.|||||||||||:  |.|....:..||::|..:..: |:|.|||||||.
Mouse    59 YGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTE 123

  Fly   272 GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHG 336
            .||:||||::.||:|||.||:...|||.:|:.|:.|:.||:.|||.|||||||:|.||||||.:|
Mouse   124 TKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNG 188

  Fly   337 HIALTDFGLSKQPL--DGSKTYSFCGTVEYMAPEIV--NRKGHDFAADWWSFGVLMYEMLTGNLP 397
            |:.||||||||:.:  :..:.||||||:|||||:||  ...|||.|.||||.||||||:|||..|
Mouse   189 HVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASP 253

  Fly   398 F----HGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFA 458
            |    ...::.|...:||:|:...|:.:|..|:.||:.|..::|:.|||.|.:...:||.|.||.
Mouse   254 FTVDGEKNSQAEISRRILKSEPPYPQEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFE 318

  Fly   459 TIDWVRLERKQVRPPFIPAVSRD--DAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVL 521
            .|.|..|..|:|..||.|.: ||  |...|..|:|...|..||.. :..|:..:|:|:|||||.:
Mouse   319 KIKWDDLAAKKVPAPFKPVI-RDELDVSNFAEEFTEMDPTYSPAA-LPQSSERLFQGYSFVAPSI 381

  Fly   522 LEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVL---------PGNFHAEYNL-LQE--L 574
            |..:    |.........|         :|..|  |||.         ...|:..|:| |::  |
Mouse   382 LFKR----NAAVIDPLQFH---------MGVDR--PGVTNVARSAMMKDSPFYQHYDLDLKDKPL 431

  Fly   575 GRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYE 639
            |.|:||:||.|.|:.:.:.:|||:|.|        ...|:..:|:..:.....|||||.|:.|:.
Mouse   432 GEGSFSICRKCVHKKTNQAFAVKIISK--------RMEANTQKEITALKLCEGHPNIVKLHEVFH 488

  Fly   640 D--AGSA---------------------------------------------------------- 644
            |  |.||
Mouse   489 DQVAASAQPPGQVVLCSLLLLALLFNRSLTRKPVTWTWLVHSTSQLPPLPPPMPEIVLFILLSDN 553

  Fly   645 -----YLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYAS 704
                 :||||||.||||.:||.......|:|||.::|.:.|||:::|:.|||||||||.|:::..
Mouse   554 GQLHTFLVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTD 618

  Fly   705 MRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSG 769
            .....| :|:.|.|||:....||..|.|||:|.::.|||:|...|||.:||:|||||:||.||||
Mouse   619 ENDNLE-IKVIDFGFARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWSLGVILYTMLSG 682

  Fly   770 RTPFASTPND----SPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILE 830
            :.||.|....    |...|:|:|..|...|....|..:|..||:|::.:|.:.|..|...:.:..
Mouse   683 QVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRY 747

  Fly   831 HDWLREQFAGGVQLTEYAVAPGSQLS---------LGAQQQQQNHISMALRGAVDATFRAIAIPQ 886
            ::||::               |||||         ||:.       ..|:...|.|||.|....:
Mouse   748 NEWLQD---------------GSQLSSNPLMTPDILGSS-------GAAVHTCVKATFHAFNKYK 790

  Fly   887 AAN--VGPVELSMLAKRRAKDRAN 908
            ...  :..|:.:.|||||...|.:
Mouse   791 REGFCLQNVDKAPLAKRRKMKRTS 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	144/268 (54%)
		STKc_RSK_N	203..517	CDD:270734	163/326 (50%)
		STKc_RSK_C	567..883	CDD:270993	126/396 (32%)
		S_TKc	568..834	CDD:214567	111/337 (33%)
Rps6ka5	NP_705815.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		6/25 (24%)
		PKc_like	47..379	CDD:304357	169/333 (51%)
		S_TKc	48..317	CDD:214567	144/268 (54%)
		STKc_MSK1_C	417..791	CDD:271081	127/404 (31%)
		S_TKc	429..751	CDD:214567	108/330 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	805..863		5/10 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850