DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and Rps6ka6

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_080225.2	Gene:	Rps6ka6 / 67071	MGIID:	1914321	Length:	860	Species:	Mus musculus

Alignment Length:	750	Identity:	418/750 - (55%)
Similarity:	526/750 - (70%)	Gaps:	68/750 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 LEDTEPL----YETENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLY 228
            :|:.||:    .|...|..:.:.:|||::||||:||:||:|||:|||||||||||..|.|||.||
Mouse   154 MEEGEPVSCRREELVKEIPITQHVKEGYEKADPAQFDLLKVLGQGSFGKVFLVRKKTGPDAGQLY 218

  Fly   229 AMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKE 293
            |||||:||:|||:||||:..||.||.:|.|.|||:|||||||.||||||||||||||:|||||||
Mouse   219 AMKVLRKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKE 283

  Fly   294 VMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYS 357
            |:||||||||||||||||::|||.|||:|||||||||||||.|||.||||||||:.:| ..|.||
Mouse   284 VLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYS 348

  Fly   358 FCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLS 422
            |||||||||||:|||:||..:|||||:||||:|||||.|||.|:.|.||||.||::|||||:.||
Mouse   349 FCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLS 413

  Fly   423 PEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYF 486
            .|||||||.||||||.|||  |::|:.::|.|.|||:|||.:|.:::|:|||.||..: ||.|.|
Mouse   414 AEAQSLLRMLFKRNPANRL--GSEGVEEVKRHAFFASIDWNKLYKREVQPPFRPASGKPDDTFCF 476

  Fly   487 DVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVG 551
            |.|:|:|:|:||||.|.||:||::|:||||||               ||.:..:.|.|:.::.|
Mouse   477 DPEFTAKTPKDSPGLPASANAHQLFKGFSFVA---------------TSIAEEYKITPVTSSNV- 525

  Fly   552 APRTLPGV-LPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTS 612
                ||.| :.||   |...|.|.:::|.|::|||:.|.|.||...:|||:|:|         ..
Mouse   526 ----LPIVQINGNAAQFSEAYELKEDIGIGSYSVCKRCIHSASNVEFAVKIIDK---------NK 577

  Fly   613 ADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRT 677
            .|..||:||::|||.||||::|..|::|....|||.:|:||||||||||......|.|||.||..
Mouse   578 RDPSEEIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILKKKCFSEQEASNVLYV 642

  Fly   678 IASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAP 742
            |...|..||..|||||||||||::|......|:::|:||.|||||||.:||||:|||||||||||
Mouse   643 ITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGENGLLLTPCYTANFVAP 707

  Fly   743 EVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPA 807
            |||.:||||.||||||||||||.||:|.|||::.|||:|:.||.|||:|:...:...|..||..|
Mouse   708 EVLTQQGYDAACDIWSLGVLLYTMLAGYTPFSNGPNDTPEEILLRIGNGRFSLSGGIWDNISRGA 772

  Fly   808 KELLRQMLHIVPENRPTAARILEHDWL--REQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMA 870
            |:||..|||:.|..|.||.::|:|.|:  |||.            |..|.:.....|:
Mouse   773 KDLLSHMLHMDPHQRYTAEQVLKHPWITQREQL------------PRHQPNSDEPPQE------- 818

  Fly   871 LRGAVDATFRAIA-IPQAAN--VGPVELSMLAKRR 902
               ||.|.:..:| .|...:  :.||..|.||:||
Mouse   819 ---AVAAPYSVLARNPNRHHPILEPVTASRLAQRR 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	193/258 (75%)
		STKc_RSK_N	203..517	CDD:270734	225/315 (71%)
		STKc_RSK_C	567..883	CDD:270993	154/317 (49%)
		S_TKc	568..834	CDD:214567	144/265 (54%)
Rps6ka6	NP_080225.2	STKc_RSK_N	193..507	CDD:270734	225/315 (71%)
Rps6ka6	NP_080225.2	STKc_RSK_C	542..828	CDD:270993	154/316 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I752
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	824	1.000	Inparanoid score	I464
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm43821
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.780