Protein Alignment S6kII and SGK1

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_001137148.1
• Gene: SGK1 / 6446
• HGNCID: 10810
• Length: 526
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 152/338 - (44%)
• Similarity: 212/338 - (62%)
• Gaps: 16/338 - (4%)

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVL-KKATLKVKDRVRSTNERKI-LADV 256
            |.||.|..|:|:|:||||||.|.|.   |.....||:||| |||.||.|:.....:||.: |.:|
Human   188 AKPSDFHFLKVIGKGSFGKVLLARH---KAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 249

  Fly   257 GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGII 321
            .|.|:|.||::|||..|||.:||::.||:||..|.:|..|.|...:||.||:|.|:.:||:|.|:
Human   250 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIV 314

  Fly   322 YRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFG 385
            ||||||||||||..|||.||||||.|:.:: .|.|.:||||.||:|||:::::.:|...|||..|
Human   315 YRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLG 379

  Fly   386 VLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILD 450
            .::||||.|..||:.:...|..:.||...|.:..|::..|:.||..|.:::...|||| ....::
Human   380 AVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA-KDDFME 443

  Fly   451 IKAHCFFATIDWVRLERKQVRPPFIPAVS-RDDAFYFDVEYTSKSPRDSPG-GP----ISAS--- 506
            ||:|.||:.|:|..|..|::.|||.|.|| .:|..:||.|:|.:...:|.| .|    ::||
Human   444 IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKE 508

  Fly   507 AHEIFRGFSFVAP 519
            |.|.|.|||:..|
Human   509 AAEAFLGFSYAPP 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	146/325 (45%)
		STKc_RSK_C	567..883	CDD:270993
SGK1	NP_001137148.1	STKc_SGK	197..519	CDD:270727	146/325 (45%)