DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and SGK1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001137148.1	Gene:	SGK1 / 6446	HGNCID:	10810	Length:	526	Species:	Homo sapiens

Alignment Length:	338	Identity:	152/338 - (44%)
Similarity:	212/338 - (62%)	Gaps:	16/338 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVL-KKATLKVKDRVRSTNERKI-LADV 256
            |.||.|..|:|:|:||||||.|.|.   |.....||:||| |||.||.|:.....:||.: |.:|
Human   188 AKPSDFHFLKVIGKGSFGKVLLARH---KAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNV 249

  Fly   257 GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGII 321
            .|.|:|.||::|||..|||.:||::.||:||..|.:|..|.|...:||.||:|.|:.:||:|.|:
Human   250 KHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIV 314

  Fly   322 YRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFG 385
            ||||||||||||..|||.||||||.|:.:: .|.|.:||||.||:|||:::::.:|...|||..|
Human   315 YRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLG 379

  Fly   386 VLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILD 450
            .::||||.|..||:.:...|..:.||...|.:..|::..|:.||..|.:::...|||| ....::
Human   380 AVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGA-KDDFME 443

  Fly   451 IKAHCFFATIDWVRLERKQVRPPFIPAVS-RDDAFYFDVEYTSKSPRDSPG-GP----ISAS--- 506
            ||:|.||:.|:|..|..|::.|||.|.|| .:|..:||.|:|.:...:|.| .|    ::||
Human   444 IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKE 508

  Fly   507 AHEIFRGFSFVAP 519
            |.|.|.|||:..|
Human   509 AAEAFLGFSYAPP 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	120/260 (46%)
		STKc_RSK_N	203..517	CDD:270734	146/325 (45%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
SGK1	NP_001137148.1	S_TKc	193..450	CDD:214567	120/260 (46%)
SGK1	NP_001137148.1	STKc_SGK	197..519	CDD:270727	146/325 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940