DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and RPS6KB2

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_003943.2	Gene:	RPS6KB2 / 6199	HGNCID:	10437	Length:	482	Species:	Homo sapiens

Alignment Length:	440	Identity:	198/440 - (45%)
Similarity:	265/440 - (60%)	Gaps:	36/440 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EGATGRSAPDLE--DTEPLYETE----------NEFELKEV-IKEGHDKADPSQFELLRVLGEGS 209
            ||:.|...|:|.  |..||.|..          .|.||.|. :..|.::..|..||||||||:|.
Human    13 EGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGG 77

  Fly   210 FGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHAFIVRLHYAFQTPG 272
            :||||.|||:.|.:.|.:||||||:||.:  ..||...:..||.||..|.|.|||.|.|||||.|
Human    78 YGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGG 142

  Fly   273 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGH 337
            ||||||:.|.||:|||.|.:|.:|.|:...|||||:.||:.|||:.||||||||||||:|...||
Human   143 KLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGH 207

  Fly   338 IALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQ 401
            |.||||||.|:.: :|:.|::||||:|||||||:.|.||:.|.||||.|.|||:||||:.||..:
Human   208 IKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAE 272

  Fly   402 TRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLE 466
            .|::||::|:|.||.:|..|:|:|:.|::...||||..|:|.|.....|::.|.||..::|..|.
Human   273 NRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLL 337

  Fly   467 RKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGG-PISASAHEIFRGFSFVAPVLLEGQCAG- 528
            ..:|.|||.|.: |.:|...||..:|.::|.|||.. .:|.||::.|.||::|||.:|:....|
Human   338 AWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGF 402

  Fly   529 -----------------SNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLP 561
                             :.:.....||.....|.|:.|......||.:||
Human   403 SFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	145/260 (56%)
		STKc_RSK_N	203..517	CDD:270734	165/318 (52%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
RPS6KB2	NP_003943.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		5/12 (42%)
		S_TKc	67..328	CDD:214567	145/260 (56%)
		STKc_p70S6K	70..392	CDD:270736	167/321 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..482		9/46 (20%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12529391	471..477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950