DRSC/TRiP Functional Genomics Resources

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Protein Alignment S6kII and RPS6KA3

DIOPT Version :9

Sequence 1:NP_001259779.1 Gene:S6kII / 33139 FlyBaseID:FBgn0262866 Length:911 Species:Drosophila melanogaster
Sequence 2:XP_011543857.1 Gene:RPS6KA3 / 6197 HGNCID:10432 Length:746 Species:Homo sapiens


Alignment Length:791 Identity:446/791 - (56%)
Similarity:547/791 - (69%) Gaps:84/791 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 LMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETE-----NEFELKEV-----IKEGHDK 193
            |.:|:|...:..||:.. .....|:...|    ||:.|.|     .|..:||:     :||||:|
Human     3 LAQLADPWQKMAVESPS-DSAENGQQIMD----EPMGEEEINPQTEEVSIKEIAITHHVKEGHEK 62

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGH 258
            |||||||||:|||:|||||||||:||.|.||..||||||||||||||:||||:..||.||.:|.|
Human    63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNH 127

  Fly   259 AFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYR 323
            .|||:|||||||.||||||||||||||||||||||||||||||||||||||||::|||:||||||
Human   128 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYR 192

  Fly   324 DLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVL 387
            |||||||||||.|||.||||||||:.:| ..|.|||||||||||||:|||:||..:|||||||||
Human   193 DLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL 257

  Fly   388 MYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRL------GAGAQ 446
            |:|||||.|||.|:.|:|||..||::|||||:.||||||||||.||||||.|||      |||..
Human   258 MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGPD 322

  Fly   447 GILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTSKSPRDSPGGPISASAHEI 510
            |:.:||.|.||:||||.:|.|:::.|||.||..| :|.||||.|:|:|:|:||||.|.||:||::
Human   323 GVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQL 387

  Fly   511 FRGFSFVAPVLLEGQCAGSNMCSTSASP------LHSIAPIPAAPVGAPRTLPGVLPGN---FHA 566
            ||||||||            :.|...|.      :|||..              .|..|   |..
Human   388 FRGFSFVA------------ITSDDESQAMQTVGVHSIVQ--------------QLHRNSIQFTD 426

  Fly   567 EYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNI 631
            .|.:.:::|.|::|||:.|.|:|:...:|||:|:|         :..|..||:||:||||.||||
Human   427 GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDK---------SKRDPTEEIEILLRYGQHPNI 482

  Fly   632 VTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLK 696
            :||..||:|....|:|.||:|||||||:||......|.||||||.||...|.|||..||||||||
Human   483 ITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK 547

  Fly   697 PSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGV 761
            |||::|......||::::||.||||||||:|||||||||||||||||||||||||.|||||||||
Human   548 PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGV 612

  Fly   762 LLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAA 826
            |||.||:|.||||:.|:|:|:.||.|||||:...:...|..:|..||:|:.:|||:.|..|.|||
Human   613 LLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAA 677

  Fly   827 RILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAIPQAANVG 891
            .:|.|.|:    ....||.:|      ||:    :|...|:   ::||:.||:.|:...|:..:.
Human   678 LVLRHPWI----VHWDQLPQY------QLN----RQDAPHL---VKGAMAATYSALNRNQSPVLE 725

  Fly   892 PVELSMLAKRR 902
            ||..|.||:||
Human   726 PVGRSTLAQRR 736

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kIINP_001259779.1 S_TKc 199..457 CDD:214567 202/264 (77%)
STKc_RSK_N 203..517 CDD:270734 235/321 (73%)
STKc_RSK_C 567..883 CDD:270993 164/315 (52%)
S_TKc 568..834 CDD:214567 151/265 (57%)
RPS6KA3XP_011543857.1 S_TKc 68..333 CDD:214567 202/264 (77%)
STKc_RSK_N 72..394 CDD:270734 235/321 (73%)
STKc_RSK2_C 408..737 CDD:271078 178/369 (48%)
Pkinase 428..685 CDD:278497 151/265 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 396 1.000 Domainoid score I752
eggNOG 1 0.900 - - E1_KOG0603
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37940
Inparanoid 1 1.050 822 1.000 Inparanoid score I470
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55819
OrthoDB 1 1.010 - - D1132245at2759
OrthoFinder 1 1.000 - - FOG0000787
OrthoInspector 1 1.000 - - otm41769
orthoMCL 1 0.900 - - OOG6_101790
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R469
SonicParanoid 1 1.000 - - X611
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.810

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