Protein Alignment S6kII and RPS6KA3

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_011543857.1
• Gene: RPS6KA3 / 6197
• HGNCID: 10432
• Length: 746
• Species: Homo sapiens
• Alignment Length: 791
• Identity: 446/791 - (56%)
• Similarity: 547/791 - (69%)
• Gaps: 84/791 - (10%)

  Fly   139 LMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETE-----NEFELKEV-----IKEGHDK 193
            |.:|:|...:..||:.. .....|:...|    ||:.|.|     .|..:||:     :||||:|
Human     3 LAQLADPWQKMAVESPS-DSAENGQQIMD----EPMGEEEINPQTEEVSIKEIAITHHVKEGHEK 62

  Fly   194 ADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGH 258
            |||||||||:|||:|||||||||:||.|.||..||||||||||||||:||||:..||.||.:|.|
Human    63 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNH 127

  Fly   259 AFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYR 323
            .|||:|||||||.||||||||||||||||||||||||||||||||||||||||::|||:||||||
Human   128 PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYR 192

  Fly   324 DLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVL 387
            |||||||||||.|||.||||||||:.:| ..|.|||||||||||||:|||:||..:|||||||||
Human   193 DLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVL 257

  Fly   388 MYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRL------GAGAQ 446
            |:|||||.|||.|:.|:|||..||::|||||:.||||||||||.||||||.|||      |||..
Human   258 MFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLVNPFLIGAGPD 322

  Fly   447 GILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYFDVEYTSKSPRDSPGGPISASAHEI 510
            |:.:||.|.||:||||.:|.|:::.|||.||..| :|.||||.|:|:|:|:||||.|.||:||::
Human   323 GVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQL 387

  Fly   511 FRGFSFVAPVLLEGQCAGSNMCSTSASP------LHSIAPIPAAPVGAPRTLPGVLPGN---FHA 566
            ||||||||            :.|...|.      :|||..              .|..|   |..
Human   388 FRGFSFVA------------ITSDDESQAMQTVGVHSIVQ--------------QLHRNSIQFTD 426

  Fly   567 EYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNI 631
            .|.:.:::|.|::|||:.|.|:|:...:|||:|:|         :..|..||:||:||||.||||
Human   427 GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDK---------SKRDPTEEIEILLRYGQHPNI 482

  Fly   632 VTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLK 696
            :||..||:|....|:|.||:|||||||:||......|.||||||.||...|.|||..||||||||
Human   483 ITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK 547

  Fly   697 PSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGV 761
            |||::|......||::::||.||||||||:|||||||||||||||||||||||||.|||||||||
Human   548 PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGV 612

  Fly   762 LLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAA 826
            |||.||:|.||||:.|:|:|:.||.|||||:...:...|..:|..||:|:.:|||:.|..|.|||
Human   613 LLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAA 677

  Fly   827 RILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAIPQAANVG 891
            .:|.|.|:    ....||.:|      ||:    :|...|:   ::||:.||:.|:...|:..:.
Human   678 LVLRHPWI----VHWDQLPQY------QLN----RQDAPHL---VKGAMAATYSALNRNQSPVLE 725

  Fly   892 PVELSMLAKRR 902
            ||..|.||:||
Human   726 PVGRSTLAQRR 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	235/321 (73%)
		STKc_RSK_C	567..883	CDD:270993	164/315 (52%)
RPS6KA3	XP_011543857.1	STKc_RSK_N	72..394	CDD:270734	235/321 (73%)
		STKc_RSK2_C	408..737	CDD:271078	178/369 (48%)