DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and RPS6KA2

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_006715612.1	Gene:	RPS6KA2 / 6196	HGNCID:	10431	Length:	761	Species:	Homo sapiens

Alignment Length:	770	Identity:	448/770 - (58%)
Similarity:	551/770 - (71%)	Gaps:	64/770 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 RREGATGRS--------APDLEDTEPLYETENEFELKEV-----IKEGHDKADPSQFELLRVLGE 207
            |.||...|:        |..|...||..:.|.|..:||:     :|||.:||||||||||:|||:
Human    31 RLEGLNRRAAGIKVVTIADCLHSREPETQHEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQ 95

  Fly   208 GSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPG 272
            ||:||||||||:.|.|||.||||||||||||||:|||||..||.|||:|.|.|||:|||||||.|
Human    96 GSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEG 160

  Fly   273 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGH 337
            |||||||||||||||||||||||||||||||||||||||::|||:|||||||||||||||||.||
Human   161 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGH 225

  Fly   338 IALTDFGLSKQPLDGSK-TYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQ 401
            |.:|||||||:.:|..| .||||||:||||||:|||:||..:||||||||||:|||||:|||.|:
Human   226 IKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGK 290

  Fly   402 TRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLE 466
            .|:|||..||::|||||:.||.||||||||||||||.||||||..|:.:||.|.||.||||..|.
Human   291 DRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLY 355

  Fly   467 RKQVRPPFIPAVSR-DDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSN 530
            ||:::|||.|||.| :|.|:||.|:|:::|.||||.|.||:||.:||||||||..|::
Human   356 RKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQ------- 413

  Fly   531 MCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKK 592
              ..|...||.   :|..|:...      |.||   |...|.:.:::|.|::|||:.|.|:|:..
Human   414 --EPSQQDLHK---VPVHPIVQQ------LHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDT 467

  Fly   593 HYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELL 657
            .||||:|:|         :..|..||:||:||||.||||:||..||:|....||||||::|||||
Human   468 EYAVKIIDK---------SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELL 523

  Fly   658 DRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQ 722
            ||||......|.|||.||.||...:.|||..|||||||||||::|.....:||::::||.|||||
Human   524 DRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQ 588

  Fly   723 LRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKR 787
            |||.|||||||||||||||||||||||||.||||||||:|||.||:|.||||:.|:|:|:.||.|
Human   589 LRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILAR 653

  Fly   788 IGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPG 852
            ||||:...:...|..||..||:::.:|||:.|..|.||.::|:|.|:..:        || ::|
Human   654 IGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNR--------EY-LSP- 708

  Fly   853 SQLSLGAQQQQQNHISMALRGAVDATFRAI-AIPQAANVGPVELSMLAKRRAKDR 906
            :|||     :|..|:   ::||:.||:.|: ..|||..:.||..|.||:||...|
Human   709 NQLS-----RQDVHL---VKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKR 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	202/258 (78%)
		STKc_RSK_N	203..517	CDD:270734	235/315 (75%)
		STKc_RSK_C	567..883	CDD:270993	164/316 (52%)
		S_TKc	568..834	CDD:214567	150/265 (57%)
RPS6KA2	XP_006715612.1	S_TKc	87..346	CDD:214567	202/258 (78%)
		STKc_RSK_N	91..407	CDD:270734	235/315 (75%)
		STKc_RSK3_C	439..731	CDD:271080	165/318 (52%)
		Pkinase	443..700	CDD:278497	150/265 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I752
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	822	1.000	Inparanoid score	I470
Isobase	1	0.950	-	0	Normalized mean entropy	S1083
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm41769
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.760