Protein Alignment S6kII and RPS6KA1

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_001006666.1
• Gene: RPS6KA1 / 6195
• HGNCID: 10430
• Length: 744
• Species: Homo sapiens
• Alignment Length: 751
• Identity: 431/751 - (57%)
• Similarity: 531/751 - (70%)
• Gaps: 62/751 - (8%)

  Fly   164 SAPDLEDTEPLYETENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLY 228
            |.|..:..|.:.:   |..:...:|.|.:|||||.||||:|||:|||||||||||:...|:|.||
Human    39 SGPQRDSDEGVLK---EISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLY 100

  Fly   229 AMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKE 293
            ||||||||||||:||||:..||.|||||.|.|:|:|||||||.||||||||||||||||||||||
Human   101 AMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKE 165

  Fly   294 VMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYS 357
            |||||||||||||||||.::|||:|||||||||||||||||.|||.||||||||:.:| ..|.||
Human   166 VMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYS 230

  Fly   358 FCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLS 422
            |||||||||||:|||:||..:|||||:||||:|||||:|||.|:.|:|||..||::|||||:.||
Human   231 FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLS 295

  Fly   423 PEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFYF 486
            .||||||||||||||.||||:|..|..:||.|.|::||||.:|.|::::|||.|||:: ||.|||
Human   296 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYF 360

  Fly   487 DVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVG 551
            |.|:||::|:||||.|.||.||::||||||||..|:|    .........:||||:..
Human   361 DTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLME----DDGKPRAPQAPLHSVVQ------- 414

  Fly   552 APRTLPGVLPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSA 613
                   .|.|.   |...|.:.:.:|.|::|.|:.|.|:|:...||||||:|         :..
Human   415 -------QLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK---------SKR 463

  Fly   614 DCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTI 678
            |..||:||:||||.||||:||..||:|....|||.||::||||||:||......|.|||.||.||
Human   464 DPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTI 528

  Fly   679 ASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPE 743
            ...|.|||..|||||||||||::|......||.|::||.||||||||:|||||||||||||||||
Human   529 GKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPE 593

  Fly   744 VLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAK 808
            ||||||||..|||||||:|||.||:|.||||:.|:|:|:.||.|||||:...:...|..:|..||
Human   594 VLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAK 658

  Fly   809 ELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMAL-R 872
            :|:.:|||:.|..|.||.::|:|.|          :|:....|.||||         |..:.| :
Human   659 DLVSKMLHVDPHQRLTAKQVLQHPW----------VTQKDKLPQSQLS---------HQDLQLVK 704

  Fly   873 GAVDATFRAI----AIPQAANVGPVELSMLAKRRAK 904
            ||:.||:.|:    ..||   :.|:|.|:||:||.:
Human   705 GAMAATYSALNSSKPTPQ---LKPIESSILAQRRVR 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	232/315 (74%)
		STKc_RSK_C	567..883	CDD:270993	163/320 (51%)
RPS6KA1	NP_001006666.1	STKc_RSK_N	75..391	CDD:270734	232/315 (74%)
		STKc_RSK1_C	425..715	CDD:271077	163/317 (51%)