Protein Alignment S6kII and rps6ka2

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_699952.2
• Gene: rps6ka2 / 571285
• ZFINID: ZDB-GENE-090827-1
• Length: 733
• Species: Danio rerio
• Alignment Length: 759
• Identity: 441/759 - (58%)
• Similarity: 539/759 - (71%)
• Gaps: 59/759 - (7%)

  Fly   156 RREGATGRSAPDLEDTEPLYETENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKII 220
            |:..:...|...|||...|    .||::...:|||.:||||||||||:|||:||:|||||||||.
Zfish    20 RKSRSKSSSLCKLEDDSIL----KEFDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKIK 80

  Fly   221 GKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGD 285
            |.|.|.||||||||||||||:|||||..||.|||:|.|.|||:|||||||.||||||||||||||
Zfish    81 GSDTGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD 145

  Fly   286 LFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL 350
            ||||||||||||||||||||||||||::|||:|||||||||||||||||.|||.:|||||||:.:
Zfish   146 LFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI 210

  Fly   351 DGSK-TYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSK 414
            |..| .||||||:||||||:|||:||..:||||||||||:|||||:|||.|:.|:|||..||::|
Zfish   211 DHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAK 275

  Fly   415 LGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVS 479
            ||||:.||||.||||||||||||.||||||..|:.:||.|.|||||||.:|.|::::|||.|||.
Zfish   276 LGMPQFLSPEVQSLLRALFKRNPSNRLGAGPDGVEEIKRHIFFATIDWNKLYRREIKPPFKPAVG 340

  Fly   480 R-DDAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIA 543
            | :|.|:||.|:||::|.||||.|.||:||::||||||||..|.:.|            ||..|.
Zfish   341 RPEDTFHFDPEFTSRTPTDSPGVPASANAHQLFRGFSFVATNLGQEQ------------PLTEIK 393

  Fly   544 PIPAAPVGAPRTLPGVLPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVA 605
            .....|:...      |.||   |...|.|.:::|.|.:|||:.|.||.:...||||:|::
Zfish   394 QNSVNPIVQQ------LHGNNIHFTDGYELKEDIGIGAYSVCKRCVHRITSVEYAVKIIDR---- 448

  Fly   606 AASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESE 670
                 :..|..||:||:||||.||||:||..||:|....||||||::|||||||||......|.|
Zfish   449 -----SKKDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQKCFSERE 508

  Fly   671 ASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCY 735
            |||||.||...|.|||..|||||||||||::|......||::::||.||||||||:|||||||||
Zfish   509 ASAVLCTITKTVEYLHSQGVVHRDLKPSNILYVDETGDPESIRICDFGFAKQLRAENGLLMTPCY 573

  Fly   736 TANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRW 800
            |||||||||||:||||.||||||||:|||.||:|.||||:.|:|:|:.||.|||||:...:...|
Zfish   574 TANFVAPEVLKKQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKFALSGGNW 638

  Fly   801 ALISVPAKELLRQMLHIVPENRPTAARILEHDWL--REQFAGGVQLTEYAVAPGSQLSLGAQQQQ 863
            ..:|..||:::.:|||:.|..|.||..:|.|.|:  |:|                   |...|..
Zfish   639 DTVSDAAKDIVTKMLHVDPHQRLTAPLVLRHAWIVNRDQ-------------------LSQSQLI 684

  Fly   864 QNHISMALRGAVDATFRAI-AIPQAANVGPVELSMLAKRRAKDR 906
            :..::: ::||:.||:.|: ..|||..:.||..|.||:||...|
Zfish   685 RQDVTL-VKGAMAATYSALNRSPQAPKLEPVLSSCLAQRRGMKR 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	236/315 (75%)
		STKc_RSK_C	567..883	CDD:270993	160/318 (50%)
rps6ka2	XP_699952.2	STKc_RSK_N	63..379	CDD:270734	236/315 (75%)
		Protein Kinases, catalytic domain	411..703	CDD:473864	161/320 (50%)