DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and sgk2a

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001107094.1	Gene:	sgk2a / 570956	ZFINID:	ZDB-GENE-030131-9632	Length:	361	Species:	Danio rerio

Alignment Length:	363	Identity:	146/363 - (40%)
Similarity:	212/363 - (58%)	Gaps:	25/363 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 EDTEPLYETENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVL 233
            :.|.|  ...||..|...:   :..|.|:.|:.|.|:|:|:||||.|.:.   |..|..||:|||
Zfish     5 DPTPP--SPSNEVNLGASV---NPHAKPTDFDFLAVIGKGTFGKVLLAKL---KADGKFYAVKVL 61

  Fly   234 -KKATLKVKDRVRSTNERKI-LADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMF 296
             ||..||.|::.....||.: |..:.|.|:|.|||:|||..|||.:||::.||:||..|.:|..|
Zfish    62 QKKVILKKKEQKNIMAERNVLLKSLKHPFLVGLHYSFQTSEKLYFVLDYVNGGELFYHLQRERCF 126

  Fly   297 TEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL--DGSKTYSFC 359
            :|...:||.||:|.|:.:||:|.|:||||||||||||..||:.||||||.|:.:  :|:.| :||
Zfish   127 SEPRARFYTAEVASAIGYLHSLNIVYRDLKPENILLDYQGHVVLTDFGLCKEGIEPEGTTT-TFC 190

  Fly   360 GTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPE 424
            ||.||:|||::.::.:|...|||..|.:::|||....||:.:...|..:.||...|.:|...|..
Zfish   191 GTPEYLAPEVLRKEPYDRTVDWWCLGAVLHEMLYSLPPFYSRDVSEMYDAILHKPLHLPPGKSES 255

  Fly   425 AQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDV 488
            |..||..|.:::...|.||.|. .|:||.|.|||.|:|..|..|::.||:.|.| ...|..:.|.
Zfish   256 ACLLLYGLLQKDQHRRTGAIAD-FLEIKNHVFFAPINWDDLYHKRITPPYNPNVRGPADLQHIDP 319

  Fly   489 EYT--------SKSPRDSPGGPISASAHEIFRGFSFVA 518
            |:|        .::|..:|.  ::.|:...|.|||:::
Zfish   320 EFTREMVPHSVGRTPEPTPS--LATSSSNAFTGFSYIS 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	117/261 (45%)
		STKc_RSK_N	203..517	CDD:270734	137/326 (42%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
sgk2a	NP_001107094.1	S_TKc	30..287	CDD:214567	117/261 (45%)
sgk2a	NP_001107094.1	STKc_SGK2	34..355	CDD:270754	137/327 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030