DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and Rps6ka4

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_064308.2	Gene:	Rps6ka4 / 56613	MGIID:	1930076	Length:	773	Species:	Mus musculus

Alignment Length:	770	Identity:	318/770 - (41%)
Similarity:	429/770 - (55%)	Gaps:	98/770 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 EFELKEVIKEGH-DKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVK 241
            |.::.|....|| :|.....|.||:|||.|::||||||||..|.|||.|||||||:||.|  :.|
Mouse    13 ELQITEANLTGHEEKVSVENFALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAALVQRAK 77

  Fly   242 DRVRSTNERKILADVGHA-FIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 305
            .:..:..||.:|..|..| |:|.|||||||..||:||||::.||::||.|.:...|.|.:|:.|.
Mouse    78 TQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYG 142

  Fly   306 AELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL--DGSKTYSFCGTVEYMAPE 368
            .|:.||:.|||.|||||||||.||:|||..|||.||||||||:.|  :..:|:|||||:||||||
Mouse   143 GEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207

  Fly   369 IVNRK-GHDFAADWWSFGVLMYEMLTGNLPF--HGQ--TRQETMNQILRSKLGMPENLSPEAQSL 428
            |:..| ||..|.||||.|:|::|:|||..||  .|:  |:.|...:||:.....|..:.|.||.|
Mouse   208 IIRSKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPLRIGPVAQDL 272

  Fly   429 LRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTS 492
            |:.|..::|:.|||||.||..::|:|.||..:|||.|..:::..||.|.: |..|...|..|:|.
Mouse   273 LQRLLCKDPKKRLGAGPQGAQEVKSHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTR 337

  Fly   493 KSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHS---IAPIPAAPVGAPR 554
            ..|..||.|........||:|:|||||.:|..               |:   :|.:..|| ||
Mouse   338 LEPVYSPAGSPPPGDPRIFQGYSFVAPSILFD---------------HNNAVMADVLQAP-GA-- 384

  Fly   555 TLPGVLPGN-------------FHAEYNL-LQE--LGRGTFSVCRLCEHRASKKHYAVKVIEKAA 603
               |..||.             |..:|.| |:|  ||:|:|||||.|..|.|.:.:|||::
Mouse   385 ---GYRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKIL---- 442

  Fly   604 VAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCE 668
                |.....:...||..:....:|||:|.|:.|..|....|||:|||:|||||:.|.......|
Mouse   443 ----SRRLEENTQREVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRLFSE 503

  Fly   669 SEASAVLRTIASAVAYLHEH-GVVHRDLKPSNMIYASMRQTP-ETLKLCDLGFAKQLRADNGL-- 729
            ||||.:||::.|||:::||. |||||||||.|::||.  .|| ..:|:.|.|||: ||..:..
Mouse   504 SEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD--DTPGAPVKIIDFGFAR-LRPQSPAEP 565

  Fly   730 LMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPD----VILKRIGS 790
            :.|||:|..:.|||:|.:||||.:||:|||||:||:||||:.||.........    .|:.:|..
Mouse   566 MQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIRE 630

  Fly   791 GQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQL 855
            |:.......|..:|..||||:|.:|.:.|..|.....:....||::   |..:.:.....|....
Mouse   631 GRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRSSSWLQD---GSARSSPPLRTPDVLE 692

  Fly   856 SLGAQQQQQNHISMALRGAVDATFRAIAIPQAANVG--------PVELSMLAKRR 902
            |.|.          |:|..::|||.|.      |.|        .||.:.|||||
Mouse   693 SSGP----------AVRSGLNATFMAF------NRGKREGFFLKSVENAPLAKRR 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	142/267 (53%)
		STKc_RSK_N	203..517	CDD:270734	161/324 (50%)
		STKc_RSK_C	567..883	CDD:270993	125/326 (38%)
		S_TKc	568..834	CDD:214567	113/276 (41%)
Rps6ka4	NP_064308.2	STKc_MSK2_N	32..364	CDD:270765	166/331 (50%)
		S_TKc	33..301	CDD:214567	142/267 (53%)
		STKc_MSK2_C	404..714	CDD:271082	128/339 (38%)
		S_TKc	417..674	CDD:214567	109/267 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..696		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..773		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950