DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and rps6ka5

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_693550.4	Gene:	rps6ka5 / 565173	ZFINID:	ZDB-GENE-130530-693	Length:	802	Species:	Danio rerio

Alignment Length:	779	Identity:	305/779 - (39%)
Similarity:	441/779 - (56%)	Gaps:	87/779 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EGATGRSAPDLEDTEPLYETENEFELKEVIKEGH-DKADPSQFELLRVLGEGSFGKVFLVRKIIG 221
            ||::|..        .|:..::  ||:.....|| ::.....||||:|||.|::||||||||:.|
Zfish     6 EGSSGEG--------DLFTVKH--ELRNANLTGHVERVGIENFELLKVLGTGAYGKVFLVRKVSG 60

  Fly   222 KDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHA-FIVRLHYAFQTPGKLYLILDFLRG 283
            .|:|.|||||||||||:  |.|....:..||::|..:..: |:|.|||||||..||:||||::.|
Zfish    61 HDSGKLYAMKVLKKATIVQKAKTAEHTRTERQVLEHIRQSPFLVTLHYAFQTDTKLHLILDYVNG 125

  Fly   284 GDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQ 348
            |:|||.|.:.|.|.|::|..|..|:.||:.|||.|||:|||||.||||||.:|||.||||||||:
Zfish   126 GELFTHLVQRVRFKEQEVTLYSGEIVLALEHLHKLGIVYRDLKLENILLDSNGHIVLTDFGLSKE 190

  Fly   349 PLDGSKTYSFCGTVEYMAPEIV--NRKGHDFAADWWSFGVLMYEMLTGNLPF----HGQTRQETM 407
            ..:..:.||.|||:||||||||  ...|||.|.||||.||||||:|||..||    ...:..:..
Zfish   191 FHEVERAYSICGTIEYMAPEIVAGGEGGHDKAVDWWSMGVLMYELLTGGSPFTVDGDENSHSDIA 255

  Fly   408 NQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRP 472
            .:|::.....|:::.|.|:.:::.|..::|:.|||:|..|..::|.|.|:..::|..|..|:||.
Zfish   256 ERIMKKDPPFPKDMGPLAKDIIQRLLIKDPKKRLGSGPSGAQNVKKHPFYQKLNWEDLAAKKVRA 320

  Fly   473 PFIPAVSRD--DAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCA----GSNM 531
            ||.|.: ||  |...|..|:|...|..||.. :..:...||:|:||:||.:|..:.|    .:.:
Zfish   321 PFKPVI-RDELDVSNFAEEFTEMDPTYSPAA-LPNNCDRIFQGYSFMAPSILFKRNAVMDDPAQL 383

  Fly   532 CSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNFHAEYNL---LQELGRGTFSVCRLCEHRASKKH 593
            |..|..|..:.....|....:|          |:..|.:   ...||.|:||:||.|.|:.:.:.
Zfish   384 CGGSERPGSAAVARSAMMKDSP----------FYMNYEMDLRHNALGEGSFSICRQCTHKKTGQK 438

  Fly   594 YAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLD 658
            ||||::.|        ...|...:|:..:.....|||||.|:.:|.|....|||:|||:|||||:
Zfish   439 YAVKIVSK--------RMEAQTQKEIAALKLCDGHPNIVKLHEIYHDQLHTYLVLELLRGGELLE 495

  Fly   659 RILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQL 723
            ||.......|:|||.::|.:.|||:::|:.|||||||||.|:::....:..| :|:.|.|||:..
Zfish   496 RIRRKQLFSETEASRIMRRLVSAVSHMHDVGVVHRDLKPENLLFTDDTENSE-IKIIDFGFARLK 559

  Fly   724 RADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPF----ASTPNDSPDVI 784
            ..||.||.|||:|..:.|||:||..|||.:||:|||||:||.||||:.||    .|..:.|.:.|
Zfish   560 PPDNQLLKTPCFTLQYAAPEILKYSGYDESCDLWSLGVILYTMLSGQVPFQCQGKSLMHTSAEEI 624

  Fly   785 LKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAV 849
            :::|..|...|....|..:|..||:|::::|.:.|:.|.....:..:.||::.
Zfish   625 MRKIKQGDFSFEGEAWRNVSSQAKDLIQELLTVDPDKRIKMCGLRYNTWLQDD------------ 677

  Fly   850 APGSQLS---------LGAQQQQQNHISMALRGAVDATFRAI--AIPQAANVGPVELSMLAKRR 902
               ||||         ||:.       ::::...|.|||.|.  ...:...:..|:.:.|||||
Zfish   678 ---SQLSSNPLMTPDILGSS-------TISVHSCVKATFNAFNKCKREGFRLQTVDKAPLAKRR 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	137/266 (52%)
		STKc_RSK_N	203..517	CDD:270734	155/324 (48%)
		STKc_RSK_C	567..883	CDD:270993	121/333 (36%)
		S_TKc	568..834	CDD:214567	108/272 (40%)
rps6ka5	XP_693550.4	PKc_like	37..367	CDD:304357	160/331 (48%)
		S_TKc	38..304	CDD:214567	137/265 (52%)
		PKc_like	405..714	CDD:304357	123/349 (35%)
		S_TKc	419..663	CDD:214567	106/252 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850