Protein Alignment S6kII and rps6ka5

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_693550.4
• Gene: rps6ka5 / 565173
• ZFINID: ZDB-GENE-130530-693
• Length: 802
• Species: Danio rerio
• Alignment Length: 779
• Identity: 305/779 - (39%)
• Similarity: 441/779 - (56%)
• Gaps: 87/779 - (11%)

  Fly   158 EGATGRSAPDLEDTEPLYETENEFELKEVIKEGH-DKADPSQFELLRVLGEGSFGKVFLVRKIIG 221
            ||::|..        .|:..::  ||:.....|| ::.....||||:|||.|::||||||||:.|
Zfish     6 EGSSGEG--------DLFTVKH--ELRNANLTGHVERVGIENFELLKVLGTGAYGKVFLVRKVSG 60

  Fly   222 KDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHA-FIVRLHYAFQTPGKLYLILDFLRG 283
            .|:|.|||||||||||:  |.|....:..||::|..:..: |:|.|||||||..||:||||::.|
Zfish    61 HDSGKLYAMKVLKKATIVQKAKTAEHTRTERQVLEHIRQSPFLVTLHYAFQTDTKLHLILDYVNG 125

  Fly   284 GDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQ 348
            |:|||.|.:.|.|.|::|..|..|:.||:.|||.|||:|||||.||||||.:|||.||||||||:
Zfish   126 GELFTHLVQRVRFKEQEVTLYSGEIVLALEHLHKLGIVYRDLKLENILLDSNGHIVLTDFGLSKE 190

  Fly   349 PLDGSKTYSFCGTVEYMAPEIV--NRKGHDFAADWWSFGVLMYEMLTGNLPF----HGQTRQETM 407
            ..:..:.||.|||:||||||||  ...|||.|.||||.||||||:|||..||    ...:..:..
Zfish   191 FHEVERAYSICGTIEYMAPEIVAGGEGGHDKAVDWWSMGVLMYELLTGGSPFTVDGDENSHSDIA 255

  Fly   408 NQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRP 472
            .:|::.....|:::.|.|:.:::.|..::|:.|||:|..|..::|.|.|:..::|..|..|:||.
Zfish   256 ERIMKKDPPFPKDMGPLAKDIIQRLLIKDPKKRLGSGPSGAQNVKKHPFYQKLNWEDLAAKKVRA 320

  Fly   473 PFIPAVSRD--DAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCA----GSNM 531
            ||.|.: ||  |...|..|:|...|..||.. :..:...||:|:||:||.:|..:.|    .:.:
Zfish   321 PFKPVI-RDELDVSNFAEEFTEMDPTYSPAA-LPNNCDRIFQGYSFMAPSILFKRNAVMDDPAQL 383

  Fly   532 CSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNFHAEYNL---LQELGRGTFSVCRLCEHRASKKH 593
            |..|..|..:.....|....:|          |:..|.:   ...||.|:||:||.|.|:.:.:.
Zfish   384 CGGSERPGSAAVARSAMMKDSP----------FYMNYEMDLRHNALGEGSFSICRQCTHKKTGQK 438

  Fly   594 YAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLD 658
            ||||::.|        ...|...:|:..:.....|||||.|:.:|.|....|||:|||:|||||:
Zfish   439 YAVKIVSK--------RMEAQTQKEIAALKLCDGHPNIVKLHEIYHDQLHTYLVLELLRGGELLE 495

  Fly   659 RILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQL 723
            ||.......|:|||.::|.:.|||:::|:.|||||||||.|:::....:..| :|:.|.|||:..
Zfish   496 RIRRKQLFSETEASRIMRRLVSAVSHMHDVGVVHRDLKPENLLFTDDTENSE-IKIIDFGFARLK 559

  Fly   724 RADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPF----ASTPNDSPDVI 784
            ..||.||.|||:|..:.|||:||..|||.:||:|||||:||.||||:.||    .|..:.|.:.|
Zfish   560 PPDNQLLKTPCFTLQYAAPEILKYSGYDESCDLWSLGVILYTMLSGQVPFQCQGKSLMHTSAEEI 624

  Fly   785 LKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAV 849
            :::|..|...|....|..:|..||:|::::|.:.|:.|.....:..:.||::.
Zfish   625 MRKIKQGDFSFEGEAWRNVSSQAKDLIQELLTVDPDKRIKMCGLRYNTWLQDD------------ 677

  Fly   850 APGSQLS---------LGAQQQQQNHISMALRGAVDATFRAI--AIPQAANVGPVELSMLAKRR 902
               ||||         ||:.       ::::...|.|||.|.  ...:...:..|:.:.|||||
Zfish   678 ---SQLSSNPLMTPDILGSS-------TISVHSCVKATFNAFNKCKREGFRLQTVDKAPLAKRR 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	155/324 (48%)
		STKc_RSK_C	567..883	CDD:270993	121/333 (36%)
rps6ka5	XP_693550.4	Protein Kinases, catalytic domain	37..367	CDD:473864	160/331 (48%)
		Protein Kinases, catalytic domain	405..714	CDD:473864	123/349 (35%)