DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and rps6kb1a

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_021327969.1	Gene:	rps6kb1a / 562242	ZFINID:	ZDB-GENE-091113-52	Length:	506	Species:	Danio rerio

Alignment Length:	429	Identity:	197/429 - (45%)
Similarity:	275/429 - (64%)	Gaps:	30/429 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 PPELMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKE-VIKEGHDKADPSQF 199
            ||| ..:||.|...|.:.....:..:|...  :||.|       :||:.| .:.:|.:|..|..|
Zfish    11 PPE-DNVSDEELSDGAKINEYIDQCSGFEF--MEDCE-------KFEISEDSVNQGTEKIRPECF 65

  Fly   200 ELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHAFIV 262
            |||||||:|.:||||.|||:.|..:|.::||||||||.:  ..||...:..||.||.:|.|.|||
Zfish    66 ELLRVLGKGGYGKVFQVRKVAGAASGKIFAMKVLKKAMIVRNAKDTAHTKAERSILEEVKHPFIV 130

  Fly   263 RLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKP 327
            .|.|||||..||||||::|.||:||.:|.:|.:|.|:...|||||::||:.|||..|||||||||
Zfish   131 DLIYAFQTGEKLYLILEYLSGGELFMQLEREGIFLEDTACFYLAEISLALGHLHQKGIIYRDLKP 195

  Fly   328 ENILLDEHGHIALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEM 391
            |||:|:.:||:.||||||.|:.: ||:.|::||||:|||||||:.|.||:.|.||||.|.|||:|
Zfish   196 ENIMLNYNGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILTRSGHNRAVDWWSLGALMYDM 260

  Fly   392 LTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCF 456
            |||..||..:.|::|:::||:.||.:|..|:.||:.||:.|.|||...|:||..:.:|||:.|.|
Zfish   261 LTGAPPFTAENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNASVRIGASPRDVLDIQRHSF 325

  Fly   457 FATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGG-PISASAHEIFRGFSFVAP 519
            |..|:|..|...::.|||.|.: |.||...||.::||::|.|||.. .:|.|.:::|.||:::||
Zfish   326 FRHINWDDLLAFKIDPPFKPFLQSADDVSQFDSKFTSQTPVDSPDDTKLSESDNQVFLGFTYIAP 390

  Fly   520 VLLEGQCAGSNMCSTSASPLHSIAPIPAAP---VGAPRT 555
            .:||           :.....:..|...:|   :|:|||
Zfish   391 SVLE-----------NIKEKFTFEPKSRSPRKVLGSPRT 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	145/260 (56%)
		STKc_RSK_N	203..517	CDD:270734	166/318 (52%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
rps6kb1a	XP_021327969.1	STKc_p70S6K	68..390	CDD:270736	167/321 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010