DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6kII and rps6ka4

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_005165672.1	Gene:	rps6ka4 / 561959	ZFINID:	ZDB-GENE-060526-284	Length:	786	Species:	Danio rerio

Alignment Length:	793	Identity:	324/793 - (40%)
Similarity:	444/793 - (55%)	Gaps:	99/793 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 GRREGATGRSAPDLEDTEPLYETEN-----EFELKEVIKEGH-DKADPSQFELLRVLGEGSFGKV 213
            |...|::|      ||::  .||..     :.|:......|: :|.....||||:|||.|::|||
Zfish     3 GDSSGSSG------EDSD--RETRRKVCTVKHEITNANLTGYTEKVGMENFELLKVLGTGAYGKV 59

  Fly   214 FLVRKIIGKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHA-FIVRLHYAFQTPGKLY 275
            ||||||.|.|.|.||||||||||.:  |.|....:..||::|..:..: |:|.|||||||..||:
Zfish    60 FLVRKISGHDKGKLYAMKVLKKAAIVQKAKTAEHTRTERQVLEHIRQSPFLVTLHYAFQTQTKLH 124

  Fly   276 LILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIAL 340
            ||||::.||::||.|.:...|:|::|:.|:.|:.||:.|||.|||:|||:|.||||||..||:.|
Zfish   125 LILDYVSGGEMFTHLYQRDHFSEDEVRIYVGEIILALEHLHKLGIVYRDIKLENILLDSDGHVVL 189

  Fly   341 TDFGLSKQPLDGSK--TYSFCGTVEYMAPEIVNRK-GHDFAADWWSFGVLMYEMLTGNLPF--HG 400
            |||||||:.|:..|  |||||||:|||||||:..| ||..|.||||.|:||:|:|||..||  .|
Zfish   190 TDFGLSKEFLEEEKERTYSFCGTIEYMAPEIIRGKSGHGKAVDWWSLGILMFELLTGASPFTLEG 254

  Fly   401 Q--TRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWV 463
            :  ::.|...:|||.:...|..:.|.||.|||.|..::|..|||:|.:|..:||.|.||..::|.
Zfish   255 ERNSQSEVSKRILRCEPPFPSIIGPLAQDLLRKLIVKDPHKRLGSGPRGAEEIKGHPFFKGLNWS 319

  Fly   464 RLERKQVRPPFIPAVSRD--DAFYFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQC 526
            .|..|:|:.||.|.: ||  |...|..|:|...|..||.. ...|...:|:|:|||||.:|
Zfish   320 DLAEKKVQSPFRPEL-RDELDVGNFAEEFTGMEPVYSPAS-TPPSTDRLFQGYSFVAPSIL---- 378

  Fly   527 AGSNMCSTSASPLHSIAPIPAAPVGAPRTLPG---------VLPGNFHAEYNLLQE---LGRGTF 579
            ...|:.         :|.:..|.|...|  ||         :....|...|.|..:   ||.|:|
Zfish   379 FNKNVV---------MADVLDAHVNVDR--PGSATVQRSAMLKESQFFQHYELCLQGSPLGEGSF 432

  Fly   580 SVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSA 644
            ||||.|.|:.|.:.||||::.:...|...        .|:..:.:..:|||||||:.||.|....
Zfish   433 SVCRKCRHKQSGQEYAVKIVSRRMEAMTQ--------REIAALRQCESHPNIVTLHEVYTDQYHT 489

  Fly   645 YLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTP 709
            |||||:|:|||||:||.......|.|||.:::::.|||:|:||.|||||||||.|:::|. ....
Zfish   490 YLVMEMLRGGELLERIRKRKMFAEWEASQLMKSLVSAVSYMHEAGVVHRDLKPENVLFAD-ESDE 553

  Fly   710 ETLKLCDLGFAKQLRADNGL--LMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTP 772
            ..||:.|.|||:...|.:|.  |.|||:|..:.|||:....|||.|||:|||||:||.||||:.|
Zfish   554 SVLKVIDFGFARLFPAGSGSAPLQTPCFTLQYAAPELFHSSGYDQACDLWSLGVILYTMLSGQVP 618

  Fly   773 FAS-----TPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHD 832
            |.|     |.:.:.| |:.:|..|........|..:|..||:|:|.:|.:.||.|...:.:.|:.
Zfish   619 FQSEKKVMTSSHAAD-IMHKIKEGDFSLDGEAWKGVSEEAKDLVRGLLTVDPERRLKLSALKENA 682

  Fly   833 WLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGAVDATFRAIAIPQAANVG------ 891
            ||:   .|||..:.....|....|.|.          .:|..|:||::|.      |.|
Zfish   683 WLQ---GGGVMSSTPLCTPDVLESTGP----------TVRTYVNATYKAF------NRGKREGFF 728

  Fly   892 --PVELSMLAKRR 902
              .|:.:.|||||
Zfish   729 LKSVDNAPLAKRR 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	143/267 (54%)
		STKc_RSK_N	203..517	CDD:270734	161/325 (50%)
		STKc_RSK_C	567..883	CDD:270993	128/325 (39%)
		S_TKc	568..834	CDD:214567	115/275 (42%)
rps6ka4	XP_005165672.1	STKc_MSK2_N	44..375	CDD:270765	167/332 (50%)
		S_TKc	45..313	CDD:214567	143/267 (54%)
		STKc_MSK2_C	414..724	CDD:271082	131/338 (39%)
		S_TKc	418..684	CDD:214567	115/275 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850