Protein Alignment S6kII and PRKG1

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 155/502 - (30%)
• Similarity: 242/502 - (48%)
• Gaps: 95/502 - (18%)

  Fly    82 TSSVTTVTSSQ----RRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTHRTLCPPPELMEL 142
            |::|.|:.:.:    .||..|.:..::.|        |..|..::..:..||.::| |...|.:|
Human   193 TATVKTLVNVKLWAIDRQCFQTIMMRTGL--------IKHTEYMEFLKSVPTFQSL-PEEILSKL 248

  Fly   143 SDSESQGGVETGGR--REGATGR------------SAPDLEDTEPLY------------------ 175
            :|...:...|.|..  |:||.|.            :..|....:|::
Human   249 ADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGE 313

  Fly   176 --ETEN---------------EFE-----LKEVIKEGHDKADP----------------SQFELL 202
              .|.|               .|:     |.:|..:.::.|:.                |.|.::
Human   314 DVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNII 378

  Fly   203 RVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATL---KVKDRVRSTNERKILADVGHAFIVRL 264
            ..||.|.||:|.||:  :..:....:|||:|||..:   :.::.:||  |::|:......|||||
Human   379 DTLGVGGFGRVELVQ--LKSEESKTFAMKILKKRHIVDTRQQEHIRS--EKQIMQGAHSDFIVRL 439

  Fly   265 HYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPEN 329
            :..|:....||::::...||:|:|.|.....|.:...:||.|.:..|..:||:.|||||||||||
Human   440 YRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPEN 504

  Fly   330 ILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTG 394
            ::||..|:..|.|||.:|:...|.||::||||.||:||||:..||||.:||:||.|:||||:|||
Human   505 LILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTG 569

  Fly   395 NLPFHGQTRQETMNQILR--SKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFF 457
            :.||.|....:|.|.|||  ..:..|:.::..|.:|::.|.:.||..|||....|:.||:.|.:|
Human   570 SPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWF 634

  Fly   458 ATIDWVRLERKQVRPPFIPAV-SRDDAFYFD--VEYTSKSPRDSPGG 501
            ...:|..|.:..:.||.||:| |..|...||  .|...:.|.|...|
Human   635 EGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSG 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	123/307 (40%)
		STKc_RSK_C	567..883	CDD:270993
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375
		CAP_ED	118..227	CDD:237999	9/41 (22%)
		CAP_ED	237..341	CDD:237999	16/104 (15%)
		STKc_cGK	381..641	CDD:270724	109/263 (41%)
		S_TK_X	636..>679	CDD:214529	14/42 (33%)