Protein Alignment S6kII and PRKCZ

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_016857278.1
• Gene: PRKCZ / 5590
• HGNCID: 9412
• Length: 603
• Species: Homo sapiens
• Alignment Length: 359
• Identity: 134/359 - (37%)
• Similarity: 198/359 - (55%)
• Gaps: 40/359 - (11%)

  Fly   135 PPPELMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIKEGHDKADPSQ- 198
            |..:..|.:|..|:   ||.|....::.|....::|       ::| :||.|| :|.|....||
Human   194 PVDDKNEDADLPSE---ETDGIAYISSSRKHDSIKD-------DSE-DLKPVI-DGMDGIKISQG 246

  Fly   199 -----FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILAD--V 256
                 |:|:||:|.||:.||.|||.   |....:|||||:||..:...:.:......|.:.:  .
Human   247 LGLQDFDLIRVIGRGSYAKVLLVRL---KKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308

  Fly   257 GHAFIVRLHYAFQT--------PGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMN 313
            .:.|:|.||..|||        |.:|:|:::::.||||...:.::....||..:||.||:.:|:|
Human   309 SNPFLVGLHSCFQTTSRLRRLSPCRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALN 373

  Fly   314 HLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDF 377
            .||..||||||||.:|:|||..|||.|||:|:.|:.| .|..|.:||||..|:||||:..:.:.|
Human   374 FLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 438

  Fly   378 AADWWSFGVLMYEMLTGNLPFHGQTRQETMNQ-------ILRSKLGMPENLSPEAQSLLRALFKR 435
            :.|||:.||||:||:.|..||...|....||.       ||...:.:|..||.:|..:|:....:
Human   439 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNK 503

  Fly   436 NPQNRLGAGAQ-GILDIKAHCFFATIDWVRLERK 468
            :|:.|||...| |..|||:|.||.:|||..:.|:
Human   504 DPKERLGCRPQTGFSDIKSHAFFRSIDWDLMHRQ 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	114/285 (40%)
		STKc_RSK_C	567..883	CDD:270993
PRKCZ	XP_016857278.1	PB1_aPKC	16..98	CDD:99725
		C1	129..183	CDD:412127
		Protein Kinases, catalytic domain	236..537	CDD:473864	119/303 (39%)