Protein Alignment S6kII and PKN1

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_998725.1
• Gene: PKN1 / 5585
• HGNCID: 9405
• Length: 948
• Species: Homo sapiens
• Alignment Length: 471
• Identity: 157/471 - (33%)
• Similarity: 234/471 - (49%)
• Gaps: 52/471 - (11%)

  Fly    92 QRRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTHRTLCP--------PPELMELSDSESQ 148
            :|::::...||..|.|.|.:.       ::|.|......|.|.|        .|.....|::.:.
Human   494 RRQKKIFSKQQGKAFQRARQM-------NIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTT 551

  Fly   149 GGVETGGRREGATGRSAPDLEDTEP------LYETENEFELKEVIKEGHDKADPS---------- 197
            |.:.......|....|:|.....:|      |.....|....|:..|..:...|:
Human   552 GDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPL 616

  Fly   198 ---QFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTN-ERKILADV-- 256
               .|:.|.|||.|.||||.|..   .:.:|.|:|:|.|||..:..:|.|.|.. |::|||.|
Human   617 TLEDFKFLAVLGRGHFGKVLLSE---FRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 678

  Fly   257 -GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGI 320
             ||.|:|.|...||||..:..::::..||||...:..:| |:|....||.|.:.|.:..||...|
Human   679 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV-FSEPRAIFYSACVVLGLQFLHEHKI 742

  Fly   321 IYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSF 384
            :|||||.:|:|||..|::.:.||||.|:.:. |.:|.:||||.|::|||::....:..|.|||..
Human   743 VYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGL 807

  Fly   385 GVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGIL 449
            |||:||||.|..||.|...:|..:.|:..::..|..||.||..::|.|.:|||:.|||:..:...
Human   808 GVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAE 872

  Fly   450 DIKAHCFFATIDWVRLERKQVRPPFIPAVS-RDDAFYFDVEYTSKSPRDSP---GGPISASAHEI 510
            |:|...||.|:.|..|..:::.|||:|.:| |.|...||.|:|.::|..||   ..|::|:....
Human   873 DVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAA 937

  Fly   511 FRGFSFVAPVLLEGQC 526
            |..|.|||     |.|
Human   938 FLDFDFVA-----GGC 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	127/322 (39%)
		STKc_RSK_C	567..883	CDD:270993
PKN1	NP_998725.1	HR1_PKN_1	<52..104	CDD:212012
		HR1_PKN1_2	127..202	CDD:212020
		HR1_PKN1_3	211..284	CDD:212026
		C2_PKN-like	395..482	CDD:176069
		STKc_PKN	621..945	CDD:270741	130/327 (40%)