DRSC/TRiP Functional Genomics Resources

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Protein Alignment S6kII and PRKCI

DIOPT Version :10

Sequence 1:NP_523437.2 Gene:S6kII / 33139 FlyBaseID:FBgn0262866 Length:911 Species:Drosophila melanogaster
Sequence 2:NP_002731.4 Gene:PRKCI / 5584 HGNCID:9404 Length:596 Species:Homo sapiens


Alignment Length:429 Identity:147/429 - (34%)
Similarity:227/429 - (52%) Gaps:54/429 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 PTADLDSARKRPTH-RTLCP-PPELMELSD--SESQGGVETGGRREGATGRSAPDLEDTEPLYET 177
            |...:|.:.....| :|:.| .|...|..|  .|.:..:.|   ||.....|:..|:|       
Human   199 PVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNT---RESGKASSSLGLQD------- 253

  Fly   178 ENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKD 242
                                 |:||||:|.||:.||.|||.   |....:|||||:||..:...:
Human   254 ---------------------FDLLRVIGRGSYAKVLLVRL---KKTDRIYAMKVVKKELVNDDE 294

  Fly   243 RVRSTNERKILAD--VGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 305
            .:......|.:.:  ..|.|:|.||..|||..:|:.:::::.||||...:.::....||..:||.
Human   295 DIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYS 359

  Fly   306 AELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEI 369
            ||::||:|:||..||||||||.:|:|||..|||.|||:|:.|:.| .|..|.:||||..|:||||
Human   360 AEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEI 424

  Fly   370 VNRKGHDFAADWWSFGVLMYEMLTGNLPFH--------GQTRQETMNQ-ILRSKLGMPENLSPEA 425
            :..:.:.|:.|||:.||||:||:.|..||.        .|..::.:.| ||..::.:|.:||.:|
Human   425 LRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKA 489

  Fly   426 QSLLRALFKRNPQNRLGAGAQ-GILDIKAHCFFATIDWVRLERKQVRPPFIPAVSRDDAF-YFDV 488
            .|:|::...::|:.|||...| |..||:.|.||..:||..:|:|||.|||.|.:|.:... .||.
Human   490 ASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDS 554

  Fly   489 EYTSKSPRDSPGGP--ISASAHEIFRGFSFVAPVLLEGQ 525
            ::|::..:.:|...  :.......|.||.::.|:|:..:
Human   555 QFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAE 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S6kIINP_523437.2 STKc_RSK_N 203..517 CDD:270734 127/329 (39%)
STKc_RSK_C 567..883 CDD:270993
PRKCINP_002731.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Regulatory domain 2..253 14/56 (25%)
Required for interaction with RAB2 2..28
PB1_aPKC 26..108 CDD:99725
Interaction with PARD6A 72..91
Pseudosubstrate. /evidence=ECO:0000250 125..134
C1_aPKC 139..193 CDD:410344
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..246 7/28 (25%)
STKc_aPKC_iota 233..596 CDD:270769 138/395 (35%)
Blue background indicates that the domain is not in the aligned region.

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