Protein Alignment S6kII and PRKACG

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_002723.2
• Gene: PRKACG / 5568
• HGNCID: 9382
• Length: 351
• Species: Homo sapiens
• Alignment Length: 344
• Identity: 136/344 - (39%)
• Similarity: 211/344 - (61%)
• Gaps: 16/344 - (4%)

  Fly   164 SAPDLEDTEPLYETENEFELKE----VIKEGH---DKADPSQFELLRVLGEGSFGKVFLVRKIIG 221
            :||..:|||. .|:.|||..|.    :.:.|:   :.|...|||.||.||.||||:|.|||.
Human     3 NAPAKKDTEQ-EESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRH--- 63

  Fly   222 KDAGTLYAMKVL-KKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGD 285
            ::.|..||||:| |:..:|:|......||::||..:...|:|:|.::|:....|||:::::.||:
Human    64 QETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGE 128

  Fly   286 LFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL 350
            :|:||.:...|:|....||.|::.||:.:||:|.:|:|||||||:|:|:.|::.:||||.:|: :
Human   129 MFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKR-V 192

  Fly   351 DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKL 415
            .| :|::.|||.||:||||:..||::.|.|||:.|||:|||..|..||:.....:...:|:..::
Human   193 KG-RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRV 256

  Fly   416 GMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPA-VS 479
            ..|..||.:.:.|||:|.:.:...|.|....|:.|||.|.:|||..|:.:..|:|..||||. ..
Human   257 RFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTG 321

  Fly   480 RDDAFYFDVEYTSKSPRDS 498
            ..||..|| :|..:..|.|
Human   322 PGDASNFD-DYEEEELRIS 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	120/298 (40%)
		STKc_RSK_C	567..883	CDD:270993
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	121/294 (41%)