Protein Alignment S6kII and PRKACB

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_891993.1
• Gene: PRKACB / 5567
• HGNCID: 9381
• Length: 398
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 126/321 - (39%)
• Similarity: 194/321 - (60%)
• Gaps: 9/321 - (2%)

  Fly   172 EPLYETENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVL-KK 235
            |.|.:.:.:| ||:......:.|....||..:.||.||||:|.||:.   |.....||||:| |:
Human    65 EFLAKAKEDF-LKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKH---KATEQYYAMKILDKQ 125

  Fly   236 ATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEED 300
            ..:|:|....:.||::||..|...|:|||.|||:....||::::::.||::|:.|.:...|:|..
Human   126 KVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 190

  Fly   301 VKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYM 365
            .:||.|::.|...:||:|.:|||||||||:|:|..|:|.:||||.:|: :.| :|::.|||.||:
Human   191 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR-VKG-RTWTLCGTPEYL 253

  Fly   366 APEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLR 430
            ||||:..||::.|.|||:.|||:|||..|..||......:...:|:..|:..|.:.|.:.:.|||
Human   254 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLR 318

  Fly   431 ALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV--SRDDAFYFDVE 489
            .|.:.:...|.|....|:.|||.|.:|||.||:.:.:::|..||||..  |.|.:.:.|.|
Human   319 NLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYE 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	118/290 (41%)
		STKc_RSK_C	567..883	CDD:270993
PRKACB	NP_891993.1	STKc_PKA	89..378	CDD:271111	118/293 (40%)