DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and Rps6ka3

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_017457618.1	Gene:	Rps6ka3 / 501560	RGDID:	1563860	Length:	759	Species:	Rattus norvegicus

Alignment Length:	752	Identity:	439/752 - (58%)
Similarity:	535/752 - (71%)	Gaps:	73/752 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 EPLYETE-----NEFELKEV-----IKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGT 226
            ||:.|.|     .|..:||:     :||||:||||||||||:|||:|||||||||:||.|.||..
  Rat    50 EPMGEEEINPQTEEGSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQ 114

  Fly   227 LYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLS 291
            ||||||||||||||:||||:..||.||.:|.|.|||:|||||||.||||||||||||||||||||
  Rat   115 LYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS 179

  Fly   292 KEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKT 355
            ||||||||||||||||||||::|||:|||||||||||||||||.|||.||||||||:.:| ..|.
  Rat   180 KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKA 244

  Fly   356 YSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPEN 420
            |||||||||||||:|||:||..:||||||||||:|||||.|||.|:.|:|||..||::|||||:.
  Rat   245 YSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF 309

  Fly   421 LSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAF 484
            ||||||||||.||||||.||||||..|:.:||.|.||:||||.:|.|:::.|||.||..| :|.|
  Rat   310 LSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTF 374

  Fly   485 YFDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASP------LHSIA 543
            |||.|:|:|:|:||||.|.||:||::||||||||            :.|...|.      :|||.
  Rat   375 YFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVA------------ITSDDESQAMQTVGVHSIV 427

  Fly   544 PIPAAPVGAPRTLPGVLPGN---FHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVA 605
            .              .|..|   |...|.:.:::|.|::|||:.|.|:|:...:|||:|:|
  Rat   428 Q--------------QLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDK---- 474

  Fly   606 AASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESE 670
                 :..|..||:||:||||.||||:||..||:|....|:|.||:|||||||:||......|.|
  Rat   475 -----SKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSERE 534

  Fly   671 ASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCY 735
            |||||.||...|.|||..|||||||||||::|......||::::||.||||||||:|||||||||
  Rat   535 ASAVLFTITKTVEYLHTQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY 599

  Fly   736 TANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRW 800
            ||||||||||||||||.||||||||||||.||:|.||||:.|:|:|:.||.|||||:...:...|
  Rat   600 TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYW 664

  Fly   801 ALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQN 865
            ..:|..||:|:.:|||:.|..|.|||.:|.|.|:    ....||.:|      ||:    :|...
  Rat   665 NSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI----VHWDQLPQY------QLN----RQDAP 715

  Fly   866 HISMALRGAVDATFRAIAIPQAANVGPVELSMLAKRR 902
            |:   ::||:.||:.|:...|:..:.||..|.||:||
  Rat   716 HL---VKGAMAATYSALNRNQSPVLEPVGRSTLAQRR 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	202/258 (78%)
		STKc_RSK_N	203..517	CDD:270734	235/315 (75%)
		STKc_RSK_C	567..883	CDD:270993	164/315 (52%)
		S_TKc	568..834	CDD:214567	151/265 (57%)
Rps6ka3	XP_017457618.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I726
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37940
Inparanoid	1	1.050	827	1.000	Inparanoid score	I435
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm45903
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.780