Protein Alignment S6kII and Akt1

DIOPT Version :9

• Sequence 1: NP_001259779.1
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_732113.3
• Gene: Akt1 / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 197/597 - (32%)
• Similarity: 281/597 - (47%)
• Gaps: 113/597 - (18%)

  Fly    19 QQQHVSSTSSSNNAEQQCSSSGLGLQLRQRMQITSSGCSSLAVTPMEHTPTEDDESGGGNSGVTS 83
            |..|.:|:.:|.:||:        ...:|.....:|.           .||.|..:...|:....
  Fly    45 QSTHPNSSPTSGSAEK--------FSWQQSWPSRTSA-----------APTHDSGTMSINTTFDL 90

  Fly    84 SVTTVTSSQRRQQLQQVQQQSALQAALEQHHI--------------------SPTADLDSA---- 124
            |..:|||.....:..||.::..|....|  ||                    |..||..|.
  Fly    91 SSPSVTSGHALTEQTQVVKEGWLMKRGE--HIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDF 153

  Fly   125 ----------------RKRP-------------THRTLCPPPEL-----MELSDSESQGGVETGG 155
                            |.:|             ..||.....||     .|...:.|...::.|
  Fly   154 LLNNFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVG- 217

  Fly   156 RREGATGRSAPDLEDTEPLYETENEFELKEVI--------KEGHDKADPSQFELLRVLGEGSFGK 212
             ....|.....|:.|.:  ..|..|.||.|..        ..|..|.....||.|:|||:|:|||
  Fly   218 -EVAMTPSEQTDMTDVD--MATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGK 279

  Fly   213 VFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRST-NERKILADVGHAFIVRLHYAFQTPGKLYL 276
            |.|.|:   |....|||:|:|||..:..||.|..| .|.::|....|.|::.|.|:|||..:|..
  Fly   280 VILCRE---KATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCF 341

  Fly   277 ILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALT 341
            ::.::.||:||..||.|.:|||:..:||.||:..|:.:||:.||||||||.||:|||:.|||.:.
  Fly   342 VMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVA 406

  Fly   342 DFGLSKQPLD-GSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQE 405
            ||||.|:.:. |..|.:||||.||:|||:::...:..|.|||..||:||||:.|.|||:.:....
  Fly   407 DFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDV 471

  Fly   406 TMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQV 470
            ....||..::..|.|::.||::||..|..::|:.|||.|...:.:|:||.|||:|:|..|..|::
  Fly   472 LFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKI 536

  Fly   471 RPPFIPAVSRD-DAFYFDVEYTSKS----PRDSPGGPISASAHE-IFRGFSFVAPVLLEGQCAG- 528
            .|||.|.|:.| |..|||.|:|.:|    |.| |.||:.:.|.| :|..||:      :|..|.
  Fly   537 PPPFKPQVTSDTDTRYFDKEFTGESVELTPPD-PTGPLGSIAEEPLFPQFSY------QGDMAST 594

  Fly   529 ---SNMCSTSAS 537
               |:..|||.|
  Fly   595 LGTSSHISTSTS 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	115/259 (44%)
		STKc_RSK_N	203..517	CDD:270734	142/321 (44%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	18/110 (16%)
		PH	107..211	CDD:278594	16/105 (15%)
		S_TKc	266..523	CDD:214567	115/259 (44%)
		STKc_PKB	270..590	CDD:270723	142/329 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940