DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and JIL-1

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001261697.1	Gene:	JIL-1 / 39241	FlyBaseID:	FBgn0020412	Length:	1207	Species:	Drosophila melanogaster

Alignment Length:	925	Identity:	278/925 - (30%)
Similarity:	416/925 - (44%)	Gaps:	147/925 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QQQQQQHVSSTSSS--NNAEQQCSSSGLGLQLRQRM-------QITSSGCSSLAVTPMEHTPTE- 70
            |:|..:.:|.||:|  .|.:....|..|..:...:|       |:.::|...........|.|.
  Fly     5 QKQNYEILSGTSTSRLKNHQHPRESESLAYEEPDQMVRNHLNGQLVANGNGKTRKNSNSETMTNG 69

  Fly    71 -----DDESGGGNSGVTSSVTTVTSSQRRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTH 130
                 :.|..|..||.|.:.....::           .:::.|...|:..|.:....::.:..|:
  Fly    70 KKSKLNTEGSGSGSGKTLNYNNNNNN-----------NNSISATNGQYTNSSSKTTSASARDYTY 123

  Fly   131 RTLCPPP-----------ELMELSDSESQ-------------------GGVE--------TGGRR 157
            |....||           :::.:||:||:                   .|:|        :..:.
  Fly   124 RETISPPTPPSPPTTNVADIVCISDAESEDGRDPEREYYDQDMEEDEPNGIEIDESSSSLSKAKS 188

  Fly   158 EGA-----------------------------TGRSAP-DLEDTEPLYETENEFELKEVIKEGHD 192
            ..|                             |..|.| ||::.....:.|...:||..:|...|
  Fly   189 NNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTSNSTPLDLDNEAHQRDLEAVTDLKYYVKLYSD 253

  Fly   193 KA-DPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILA 254
            :| ..:.|:::||||.|::|:||||||:...|||.|||||||.|.|:  |.|....:..||.:|.
  Fly   254 EAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLE 318

  Fly   255 DV-GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTL 318
            .: .:.|:|.||||||:..||||:|||..||:|||.|.....|.|..|:.|:||:.||:..||.|
  Fly   319 AIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQL 383

  Fly   319 GIIYRDLKPENILLDEHGHIALTDFGLSK--QPLDGSKTYSFCGTVEYMAPEIVNR--KGHDFAA 379
            ||||||:|.||||||..|||.|:||||||  ...:..:.:|||||:|||||||:..  .|||.|.
  Fly   384 GIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEYRAHSFCGTLEYMAPEIIRTGPPGHDSAV 448

  Fly   380 DWWSFGVLMYEMLTGNLPF---HGQTRQ-ETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNR 440
            ||||.|||.:|:|||..||   .||.:| |...:|.:.:..:|.:.|..|:..:..:.::||:.|
  Fly   449 DWWSVGVLTFELLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRR 513

  Fly   441 LGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGGPIS 504
            ||...:...:||.|.||..|:|..|..|:.:.|:.|.: :.||...|..|:|.:.|.| |.....
  Fly   514 LGGNHRDASEIKEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPED-PECDAP 577

  Fly   505 ASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLPGNFHAEYN 569
            .|...:|||:::|||..|| |....|.|....... .:..||..|                .:..
  Fly   578 PSRIRLFRGYTYVAPEHLE-QMRRDNHCEIQYFNT-GLQNIPCRP----------------DDLE 624

  Fly   570 LLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTL 634
            |......|.:..|......::...:..|:|..:....:.......|      .|...||.|||:.
  Fly   625 LGTRTSNGAYGTCHFVVDSSTDLVFLAKIIPLSKFRPSEVDALISC------ALDTTNHKNIVSY 683

  Fly   635 YSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSN 699
            :..:.:....::|||.|.|.||...|    :|.|.....:...:..||.::|....:|.||||.|
  Fly   684 HGTFREKCETWIVMEYLSGPELTASI----RMDEDSCREIFLQLVMAVRHIHSKHFIHGDLKPEN 744

  Fly   700 MIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQG---YDLACDIWSLGV 761
            :::.:  :...|:||.|.|.|............|.||.::..||:|....   |..|.||:.||.
  Fly   745 IMFEN--REDRTVKLIDFGSACYNNRFKSWKDKPRYTLDYAPPEMLADANLVTYSPAVDIYGLGA 807

  Fly   762 LLYIMLSGRTPFASTPND------SPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPE 820
            .||.||.|..|:....:|      :...:.||:..|..:..|.||...|...:.|:...|...|.
  Fly   808 TLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRGTFNQRSMRWESASPAFRHLVSWCLQRDPA 872

  Fly   821 NRPTAARILEHDWLR 835
            :|||.:.||:.:||:
  Fly   873 DRPTLSDILDSEWLQ 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	130/268 (49%)
		STKc_RSK_N	203..517	CDD:270734	149/325 (46%)
		STKc_RSK_C	567..883	CDD:270993	73/278 (26%)
		S_TKc	568..834	CDD:214567	71/274 (26%)
JIL-1	NP_001261697.1	S_TKc	261..530	CDD:214567	130/268 (49%)
		STKc_MSK_N	266..533	CDD:270735	130/266 (49%)
		S_TK_X	532..591	CDD:214529	18/59 (31%)
		S_TKc	632..886	CDD:214567	70/265 (26%)
		PKc_like	632..885	CDD:304357	70/264 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0603
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.750