Protein Alignment S6kII and Rps6ka4

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: NP_001101987.2
• Gene: Rps6ka4 / 361715
• RGDID: 1307277
• Length: 773
• Species: Rattus norvegicus
• Alignment Length: 770
• Identity: 320/770 - (41%)
• Similarity: 431/770 - (55%)
• Gaps: 98/770 - (12%)

  Fly   180 EFELKEVIKEGH-DKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVK 241
            |.::.|....|| :|.....|.||:|||.|::||||||||..|.|||.|||||||:||.|  :.|
  Rat    13 ELQITEANLTGHEEKVSVENFALLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAK 77

  Fly   242 DRVRSTNERKILADVGHA-FIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYL 305
            .:..:..||.:|..|..| |:|.|||||||..||:||||::.||::||.|.:...|.|.:|:.|.
  Rat    78 TQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYG 142

  Fly   306 AELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL--DGSKTYSFCGTVEYMAPE 368
            .|:.||:.|||.|||||||||.||:|||..|||.||||||||:.|  :..:|:|||||:||||||
  Rat   143 GEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207

  Fly   369 IVNRK-GHDFAADWWSFGVLMYEMLTGNLPF--HGQ--TRQETMNQILRSKLGMPENLSPEAQSL 428
            |:..| ||..|.||||.|:|::|:|||..||  .|:  |:.|...:||:.....|..:.|.||.|
  Rat   208 IIRSKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDL 272

  Fly   429 LRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAV-SRDDAFYFDVEYTS 492
            |:.|..::|:.|||||.||..::|:|.||..:|||.|..:::..||.|.: |..|...|..|:|.
  Rat   273 LQRLLCKDPKKRLGAGPQGAQEVKSHLFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTR 337

  Fly   493 KSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHS---IAPIPAAPVGAPR 554
            ..|..||.|........||:|:|||||.:|..               |:   :|.:.||| ||
  Rat   338 LEPVYSPAGSPPPGDPRIFQGYSFVAPSILFD---------------HNNAVMADVLAAP-GA-- 384

  Fly   555 TLPGVLPGN-------------FHAEYNL-LQE--LGRGTFSVCRLCEHRASKKHYAVKVIEKAA 603
               |..||.             |..:|.| |:|  ||:|:|||||.|..|.|.:.:|||::
  Rat   385 ---GYRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKIL---- 442

  Fly   604 VAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCE 668
                |.....:...||..:....:|||:|.|:.|..|....|||:|||:|||||:.|.......|
  Rat   443 ----SRRLEENTQREVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRLFSE 503

  Fly   669 SEASAVLRTIASAVAYLHEH-GVVHRDLKPSNMIYASMRQTP-ETLKLCDLGFAKQLRADN--GL 729
            ||||.:||::.|||:::||. |||||||||.|::||.  .|| ..:|:.|.|||: ||..:  |.
  Rat   504 SEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD--DTPGAPVKIIDFGFAR-LRPQSPAGP 565

  Fly   730 LMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPD----VILKRIGS 790
            :.|||:|..:.|||:|.:||||.:||:|||||:||:||||:.||.........    .|:.:|..
  Rat   566 MQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIRE 630

  Fly   791 GQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQL 855
            |:.......|..:|..||||:|.:|.:.|..|.....:....||::   |..:.:.....|....
  Rat   631 GRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRSSSWLQD---GSARSSPPLRTPDVLE 692

  Fly   856 SLGAQQQQQNHISMALRGAVDATFRAIAIPQAANVG--------PVELSMLAKRR 902
            |.|.          |:|..::|||.|.      |.|        .||.:.|||||
  Rat   693 SSGP----------AVRSGLNATFMAF------NRGKREGFFLKSVENAPLAKRR 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	161/324 (50%)
		STKc_RSK_C	567..883	CDD:270993	126/326 (39%)
Rps6ka4	NP_001101987.2	STKc_MSK2_N	32..364	CDD:270765	166/331 (50%)
		Protein Kinases, catalytic domain	404..714	CDD:473864	129/339 (38%)