DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and Rps6kb2

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001010962.2	Gene:	Rps6kb2 / 361696	RGDID:	1305144	Length:	485	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	197/440 - (44%)
Similarity:	266/440 - (60%)	Gaps:	36/440 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EGATGRSAPDLE--DTEPLYETE----------NEFELKE-VIKEGHDKADPSQFELLRVLGEGS 209
            ||:.|...|:..  |..||.|..          .|.||.| .:..|.::..|..||||.|||:|.
  Rat    13 EGSEGEGEPEFNPADVCPLGELRAAGLETVGHYEEVELTESSVNLGPERIGPHCFELLSVLGKGG 77

  Fly   210 FGKVFLVRKIIGKDAGTLYAMKVLKKATL--KVKDRVRSTNERKILADVGHAFIVRLHYAFQTPG 272
            :||||.|||:.|.:.|.:||||||:||.:  ..||...:..||.||..|.|.|||.|.|||||.|
  Rat    78 YGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIVELAYAFQTGG 142

  Fly   273 KLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGH 337
            ||||||:.|.||:|||.|.:|.:|.|:...|||||:.||:.|||:.||||||||||||:|:..||
  Rat   143 KLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLNSQGH 207

  Fly   338 IALTDFGLSKQPL-DGSKTYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQ 401
            |.||||||.|:.: :|:.|::||||:|||||||:.|.||:.|.||||.|.|||:||||:.||..:
  Rat   208 IKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRIGHNRAVDWWSLGALMYDMLTGSPPFTAE 272

  Fly   402 TRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLE 466
            .|::||::|::.||.:|..|:|:|:.|.:...||||.:|:|.|.....|::.|.||..|:|..|.
  Rat   273 NRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTHRIGGGPGDAADVQRHPFFRHINWDDLL 337

  Fly   467 RKQVRPPFIPAV-SRDDAFYFDVEYTSKSPRDSPGG-PISASAHEIFRGFSFVAPVLLEGQCAG- 528
            ..:|.|||.|:: |.:|...|||.:|.::|.|||.. .:|.||::.|.||::|||.:|:....|
  Rat   338 AHRVDPPFRPSLQSEEDVSQFDVRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGF 402

  Fly   529 -----------------SNMCSTSASPLHSIAPIPAAPVGAPRTLPGVLP 561
                             :.:.....||.....|.|..|.....:||.:||
  Rat   403 SFQPKLRSPRRLNSSPRTPISPLKFSPFEGFRPSPGPPEPMEPSLPPLLP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	143/260 (55%)
		STKc_RSK_N	203..517	CDD:270734	165/318 (52%)
		STKc_RSK_C	567..883	CDD:270993
		S_TKc	568..834	CDD:214567
Rps6kb2	NP_001010962.2	STKc_p70S6K	70..392	CDD:270736	167/321 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920