Protein Alignment S6kII and rps6ka3a

DIOPT Version :10

• Sequence 1: NP_523437.2
• Gene: S6kII / 33139
• FlyBaseID: FBgn0262866
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_005165175.1
• Gene: rps6ka3a / 338219
• ZFINID: ZDB-GENE-030219-119
• Length: 733
• Species: Danio rerio
• Alignment Length: 743
• Identity: 436/743 - (58%)
• Similarity: 535/743 - (72%)
• Gaps: 53/743 - (7%)

  Fly   168 LEDTEPLYETENEFELKEV-----IKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTL 227
            :||...:::   |..:||:     :|||.:||||.||||.:|||:|||||||||:||.|.|||.|
Zfish    26 IEDDSLVHD---EGSVKEISITHHVKEGSEKADPRQFELRKVLGQGSFGKVFLVKKISGPDAGQL 87

  Fly   228 YAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSK 292
            |||||||||||||:||||:..||.||.:|.|.|||:|||||||.|||||||||||||||||||||
Zfish    88 YAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 152

  Fly   293 EVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTY 356
            |||||||||||||||||||::|||.||||||||||||||||:.|||.||||||||:.:| .:|.|
Zfish   153 EVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDDDGHIKLTDFGLSKESIDHENKAY 217

  Fly   357 SFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENL 421
            ||||||||||||:|||:||..:|||||:||||:|||||.|||.|:.|:|||..||::|||||:.|
Zfish   218 SFCGTVEYMAPEVVNRRGHTQSADWWSYGVLMFEMLTGALPFQGKDRKETMTMILKAKLGMPQFL 282

  Fly   422 SPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFY 485
            |||||||||.||||||.||||||..|:..||.|.||..|||.:|.||:|.|||.||:.: ||.||
Zfish   283 SPEAQSLLRNLFKRNPGNRLGAGPDGVEGIKRHSFFTRIDWNKLFRKEVPPPFKPAIKKPDDTFY 347

  Fly   486 FDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPV 550
            ||.|:|:|:||||||.|.||:||::||||||||..:.|          .|.||:.|...:.:...
Zfish   348 FDSEFTAKTPRDSPGVPPSANAHQLFRGFSFVATGVEE----------ESQSPIQSNINMSSILQ 402

  Fly   551 GAPR-TLPGVLPGNFHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSAD 614
            .:.| ||      .|...|.:.:::|.|::|||:.|..:::...||||:|:|         ...|
Zfish   403 QSHRSTL------QFTDAYEVKEDIGVGSYSVCKRCVQKSTGMDYAVKIIKK---------ERRD 452

  Fly   615 CWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIA 679
            ..|||||:||||.||||:||..|::|..|.|||.||:|||||||:||......|.||||||.||.
Zfish   453 PTEEVEILLRYGQHPNIITLKDVFDDGRSVYLVTELMKGGELLDKILRQKFFSEREASAVLYTIT 517

  Fly   680 SAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEV 744
            ..|.|||..|||||||||||::|......||::::||.||||||||:||||||||||||||||||
Zfish   518 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEV 582

  Fly   745 LKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKE 809
            ||:||||.||||||||||||.||:|.||||:.|.|:|:.||.|||||:...|...|..:|..||:
Zfish   583 LKKQGYDAACDIWSLGVLLYTMLTGFTPFANGPEDTPEEILARIGSGKFSLTGGYWNSVSHDAKD 647

  Fly   810 LLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGA 874
            |:.:|||:.|..|.|||::|.|.|:..:    .||.:|      ||:    :|...|:   ::||
Zfish   648 LVSKMLHVDPHKRLTAAQVLRHPWIINK----DQLPKY------QLN----RQDAPHL---VKGA 695

  Fly   875 VDATFRAIAIPQAANVGPVELSMLAKRR 902
            :.||:.|:....:..:.||..|.||:||
Zfish   696 MAATYSALNRNVSPVLDPVGCSTLAQRR 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_523437.2	STKc_RSK_N	203..517	CDD:270734	236/315 (75%)
		STKc_RSK_C	567..883	CDD:270993	165/315 (52%)
rps6ka3a	XP_005165175.1	STKc_RSK_N	63..379	CDD:270734	236/315 (75%)
		STKc_RSK2_C	395..733	CDD:271078	176/361 (49%)