DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S6kII and rps6ka3a

DIOPT Version :9

Sequence 1:	NP_001259779.1	Gene:	S6kII / 33139	FlyBaseID:	FBgn0262866	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	XP_005165175.1	Gene:	rps6ka3a / 338219	ZFINID:	ZDB-GENE-030219-119	Length:	733	Species:	Danio rerio

Alignment Length:	743	Identity:	436/743 - (58%)
Similarity:	535/743 - (72%)	Gaps:	53/743 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 LEDTEPLYETENEFELKEV-----IKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTL 227
            :||...:::   |..:||:     :|||.:||||.||||.:|||:|||||||||:||.|.|||.|
Zfish    26 IEDDSLVHD---EGSVKEISITHHVKEGSEKADPRQFELRKVLGQGSFGKVFLVKKISGPDAGQL 87

  Fly   228 YAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSK 292
            |||||||||||||:||||:..||.||.:|.|.|||:|||||||.|||||||||||||||||||||
Zfish    88 YAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 152

  Fly   293 EVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTY 356
            |||||||||||||||||||::|||.||||||||||||||||:.|||.||||||||:.:| .:|.|
Zfish   153 EVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDDDGHIKLTDFGLSKESIDHENKAY 217

  Fly   357 SFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENL 421
            ||||||||||||:|||:||..:|||||:||||:|||||.|||.|:.|:|||..||::|||||:.|
Zfish   218 SFCGTVEYMAPEVVNRRGHTQSADWWSYGVLMFEMLTGALPFQGKDRKETMTMILKAKLGMPQFL 282

  Fly   422 SPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFFATIDWVRLERKQVRPPFIPAVSR-DDAFY 485
            |||||||||.||||||.||||||..|:..||.|.||..|||.:|.||:|.|||.||:.: ||.||
Zfish   283 SPEAQSLLRNLFKRNPGNRLGAGPDGVEGIKRHSFFTRIDWNKLFRKEVPPPFKPAIKKPDDTFY 347

  Fly   486 FDVEYTSKSPRDSPGGPISASAHEIFRGFSFVAPVLLEGQCAGSNMCSTSASPLHSIAPIPAAPV 550
            ||.|:|:|:||||||.|.||:||::||||||||..:.|          .|.||:.|...:.:...
Zfish   348 FDSEFTAKTPRDSPGVPPSANAHQLFRGFSFVATGVEE----------ESQSPIQSNINMSSILQ 402

  Fly   551 GAPR-TLPGVLPGNFHAEYNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSAD 614
            .:.| ||      .|...|.:.:::|.|::|||:.|..:::...||||:|:|         ...|
Zfish   403 QSHRSTL------QFTDAYEVKEDIGVGSYSVCKRCVQKSTGMDYAVKIIKK---------ERRD 452

  Fly   615 CWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIA 679
            ..|||||:||||.||||:||..|::|..|.|||.||:|||||||:||......|.||||||.||.
Zfish   453 PTEEVEILLRYGQHPNIITLKDVFDDGRSVYLVTELMKGGELLDKILRQKFFSEREASAVLYTIT 517

  Fly   680 SAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEV 744
            ..|.|||..|||||||||||::|......||::::||.||||||||:||||||||||||||||||
Zfish   518 KTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEV 582

  Fly   745 LKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKE 809
            ||:||||.||||||||||||.||:|.||||:.|.|:|:.||.|||||:...|...|..:|..||:
Zfish   583 LKKQGYDAACDIWSLGVLLYTMLTGFTPFANGPEDTPEEILARIGSGKFSLTGGYWNSVSHDAKD 647

  Fly   810 LLRQMLHIVPENRPTAARILEHDWLREQFAGGVQLTEYAVAPGSQLSLGAQQQQQNHISMALRGA 874
            |:.:|||:.|..|.|||::|.|.|:..:    .||.:|      ||:    :|...|:   ::||
Zfish   648 LVSKMLHVDPHKRLTAAQVLRHPWIINK----DQLPKY------QLN----RQDAPHL---VKGA 695

  Fly   875 VDATFRAIAIPQAANVGPVELSMLAKRR 902
            :.||:.|:....:..:.||..|.||:||
Zfish   696 MAATYSALNRNVSPVLDPVGCSTLAQRR 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6kII	NP_001259779.1	S_TKc	199..457	CDD:214567	200/258 (78%)
		STKc_RSK_N	203..517	CDD:270734	236/315 (75%)
		STKc_RSK_C	567..883	CDD:270993	165/315 (52%)
		S_TKc	568..834	CDD:214567	152/265 (57%)
rps6ka3a	XP_005165175.1	S_TKc	59..318	CDD:214567	200/258 (78%)
		STKc_RSK_N	63..379	CDD:270734	236/315 (75%)
		STKc_RSK2_C	395..733	CDD:271078	176/361 (49%)
		Pkinase	415..672	CDD:278497	152/265 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I709
eggNOG	1	0.900	-	-		E1_KOG0603
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	828	1.000	Inparanoid score	I444
OMA	1	1.010	-	-		QHG55819
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	1	1.000	-	-		FOG0000787
OrthoInspector	1	1.000	-	-		otm24234
orthoMCL	1	0.900	-	-		OOG6_101790
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.780